MEK1/2 inhibition attenuates vascular ETA and ETB receptor alterations after cerebral ischaemia.
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Protein kinase C inhibition attenuates vascular ETB receptor upregulation and decreases brain damage after cerebral ischemia in ratEnhanced expressions of microvascular smooth muscle receptors after focal cerebral ischemia occur via the MAPK MEK/ERK pathway.Enhanced cerebrovascular expression of matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 via the MEK/ERK pathway during cerebral ischemia in the ratCaMKII and MEK1/2 inhibition time-dependently modify inflammatory signaling in rat cerebral arteries during organ culture.Human cerebrovascular contractile receptors are upregulated via a B-Raf/MEK/ERK-sensitive signaling pathway.Inhibition of cerebrovascular raf activation attenuates cerebral blood flow and prevents upregulation of contractile receptors after subarachnoid hemorrhage.Cigarette smoke upregulates rat coronary artery endothelin receptors in vivoDerangements of post-ischemic cerebral blood flow by protein kinase C deltaExpressional changes in cerebrovascular receptors after experimental transient forebrain ischemiaMAPK signaling pathway regulates cerebrovascular receptor expression in human cerebral arteries.Blockade of the MEK/ERK pathway with a raf inhibitor prevents activation of pro-inflammatory mediators in cerebral arteries and reduction in cerebral blood flow after subarachnoid hemorrhage in a rat model.Male-female differences in upregulation of vasoconstrictor responses in human cerebral arteries.Cerebrospinal fluid from patients with subarachnoid haemorrhage and vasospasm enhances endothelin contraction in rat cerebral arteries.Early MEK1/2 inhibition after global cerebral ischemia in rats reduces brain damage and improves outcome by preventing delayed vasoconstrictor receptor upregulationU0126 attenuates cerebral vasoconstriction and improves long-term neurologic outcome after stroke in female ratsSecondhand smoke exposure induces Raf/ERK/MAPK-mediated upregulation of cerebrovascular endothelin ETA receptorsEstrogen neuroprotection and the critical period hypothesis.Oestrogen signalling and neuroprotection in cerebral ischaemia.tPA-S(481)A prevents impairment of cerebrovascular autoregulation by endogenous tPA after traumatic brain injury by upregulating p38 MAPK and inhibiting ET-1.Vascular plasticity in cerebrovascular disorders.Cerebral ischemia induces microvascular pro-inflammatory cytokine expression via the MEK/ERK pathway.In vivo experimental stroke and in vitro organ culture induce similar changes in vasoconstrictor receptors and intracellular calcium handling in rat cerebral arteries.Activating deltaPKC antagonizes the protective effect of ERK1/2 inhibition against stroke in rats.Lipopolysaccharide enhanced renal vascular response to endothelin-1 through ETA overexpression in portal hypertensive rats.P2 receptor antagonists prevent synaptic failure and extracellular signal-regulated kinase 1/2 activation induced by oxygen and glucose deprivation in rat CA1 hippocampus in vitro.Inhibition of mitogen-activated protein kinase 1/2 in the acute phase of stroke improves long-term neurological outcome and promotes recovery processes in rats.Picroside II Inhibits the MEK-ERK1/2-COX2 Signal Pathway to Prevent Cerebral Ischemic Injury in Rats.ERK inhibition with PD184161 mitigates brain damage in a mouse model of stroke.Inhibiting of GRASP65 Phosphorylation by DL-3-N-Butylphthalide Protects against Cerebral Ischemia-Reperfusion Injury via ERK Signaling
P2860
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P2860
MEK1/2 inhibition attenuates vascular ETA and ETB receptor alterations after cerebral ischaemia.
description
2006 nî lūn-bûn
@nan
2006 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
name
MEK1/2 inhibition attenuates v ...... ions after cerebral ischaemia.
@ast
MEK1/2 inhibition attenuates v ...... ions after cerebral ischaemia.
@en
type
label
MEK1/2 inhibition attenuates v ...... ions after cerebral ischaemia.
@ast
MEK1/2 inhibition attenuates v ...... ions after cerebral ischaemia.
@en
prefLabel
MEK1/2 inhibition attenuates v ...... ions after cerebral ischaemia.
@ast
MEK1/2 inhibition attenuates v ...... ions after cerebral ischaemia.
@en
P2093
P2860
P1476
MEK1/2 inhibition attenuates v ...... tions after cerebral ischaemia
@en
P2093
Emelie Stenman
Marie Henriksson
Petter Vikman
P2860
P2888
P304
P356
10.1007/S00221-006-0753-7
P577
2006-11-08T00:00:00Z
P6179
1035355152