The stem cell population of the human colon crypt: analysis via methylation patterns
about
Deficient expression of DNA repair enzymes in early progression to sporadic colon cancerEpigenetic field defects in progression to cancerCancer etiology. Variation in cancer risk among tissues can be explained by the number of stem cell divisionsCancer evolution: mathematical models and computational inferenceComparing algorithms that reconstruct cell lineage trees utilizing information on microsatellite mutationsStem cell dynamics and pretumor progression in the intestinal tractStochastic Tunneling of Two Mutations in a Population of Cancer CellsAge-specific incidence of cancer: Phases, transitions, and biological implicationsA calibrated agent-based computer model of stochastic cell dynamics in normal human colon crypts useful for in silico experiments.Single-molecule genomic data delineate patient-specific tumor profiles and cancer stem cell organization.Asymmetric strand segregation: epigenetic costs of genetic fidelity?Using DNA methylation patterns to infer tumor ancestry.The evolutionary trade-off between stem cell niche size, aging, and tumorigenesis.Inferring human stem cell behaviour from epigenetic drift.Passenger mutations as a marker of clonal cell lineages in emerging neoplasiaIntestinal epithelial stem cells do not protect their genome by asymmetric chromosome segregation.Symmetric vs. asymmetric stem cell divisions: an adaptation against cancer?A Multiscale Model Evaluates Screening for Neoplasia in Barrett's EsophagusPreventing clonal evolutionary processes in cancer: Insights from mathematical models.The role of the Hes1 crosstalk hub in Notch-Wnt interactions of the intestinal crypt.Intratumor heterogeneity in human glioblastoma reflects cancer evolutionary dynamics.The implications of small stem cell niche sizes and the distribution of fitness effects of new mutations in aging and tumorigenesis.Intra-tumor heterogeneity of MLH1 promoter methylation revealed by deep single molecule bisulfite sequencing.Investigating the fixation and spread of mutations in the gastrointestinal epithelium.Stem cells and their implications for colorectal cancer.Stem cell identification--in vivo lineage analysis versus in vitro isolation and clonal expansion.Using tumour phylogenetics to identify the roots of metastasis in humans.A population genetics perspective on the determinants of intra-tumor heterogeneity.Spatial structure increases the waiting time for cancer.Inferring cell differentiation processes based on phylogenetic analysis of genome-wide epigenetic information: hematopoiesis as a model case.Stochastic dynamics of cancer initiation.Modeling of stem cell dynamics in human colonic crypts in silico.Large chromosome deletions, duplications, and gene conversion events accumulate with age in normal human colon crypts.Mice lacking functional CD95-ligand display reduced proliferation of the intestinal epithelium without gross homeostatic alterations.
P2860
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P2860
The stem cell population of the human colon crypt: analysis via methylation patterns
description
2007 nî lūn-bûn
@nan
2007 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
name
The stem cell population of the human colon crypt: analysis via methylation patterns
@ast
The stem cell population of the human colon crypt: analysis via methylation patterns
@en
type
label
The stem cell population of the human colon crypt: analysis via methylation patterns
@ast
The stem cell population of the human colon crypt: analysis via methylation patterns
@en
prefLabel
The stem cell population of the human colon crypt: analysis via methylation patterns
@ast
The stem cell population of the human colon crypt: analysis via methylation patterns
@en
P2093
P2860
P1476
The stem cell population of the human colon crypt: analysis via methylation patterns
@en
P2093
Darryl Shibata
Kyoung-Mee Kim
Pierre Nicolas
Simon Tavaré
P2860
P356
10.1371/JOURNAL.PCBI.0030028
P577
2007-01-02T00:00:00Z