A K ATP channel-dependent pathway within alpha cells regulates glucagon release from both rodent and human islets of Langerhans.
about
Glucagon secretion and signaling in the development of diabetesHow ATP inhibits the open K(ATP) channelSynaptotagmin-7 is a principal Ca2+ sensor for Ca2+ -induced glucagon exocytosis in pancreasHands-on experiments on glycemia regulation and type 1 diabetesPhysiology of proglucagon peptides: role of glucagon and GLP-1 in health and diseasePer-arnt-sim (PAS) domain-containing protein kinase is downregulated in human islets in type 2 diabetes and regulates glucagon secretionObesity: Current and potential pharmacotherapeutics and targets.Pancreatic β-cell-specific ablation of TASK-1 channels augments glucose-stimulated calcium entry and insulin secretion, improving glucose tolerance.ATP-sensitive K+ channel mediates the zinc switch-off signal for glucagon response during glucose deprivation.Patients With Long-QT Syndrome Caused by Impaired hERG-Encoded Kv11.1 Potassium Channel Have Exaggerated Endocrine Pancreatic and Incretin Function Associated With Reactive Hypoglycemia.CFTR is involved in the regulation of glucagon secretion in human and rodent alpha cells.Glucose suppression of glucagon secretion: metabolic and calcium responses from alpha-cells in intact mouse pancreatic islets.Model for glucagon secretion by pancreatic α-cells.Cell signalling in insulin secretion: the molecular targets of ATP, cAMP and sulfonylurea.Glucose decouples intracellular Ca2+ activity from glucagon secretion in mouse pancreatic islet alpha-cellsMitochondrial GTP insensitivity contributes to hypoglycemia in hyperinsulinemia hyperammonemia by inhibiting glucagon release.Partial inhibition of insulin secretion results in glucose intolerance but not hyperglucagonemia.Targeting SUR1/Abcc8-type neuroendocrine KATP channels in pancreatic islet cells.TASK-1 Potassium Channels Limit Pancreatic α-Cell Calcium Influx and Glucagon Secretion.Role of monosaccharide transport proteins in carbohydrate assimilation, distribution, metabolism, and homeostasis.A computational systems analysis of factors regulating α cell glucagon secretion.Intra-islet glucagon secretion and action in the regulation of glucose homeostasis.UCP2 regulates the glucagon response to fasting and starvationTolbutamide controls glucagon release from mouse islets differently than glucose: involvement of K(ATP) channels from both α-cells and δ-cells.Paracrine regulation of glucagon secretion: the β/α/δ model.Long-term exposure of mouse pancreatic islets to oleate or palmitate results in reduced glucose-induced somatostatin and oversecretion of glucagonUCP2 is highly expressed in pancreatic alpha-cells and influences secretion and survival.Somatostatin secreted by islet delta-cells fulfills multiple roles as a paracrine regulator of islet function.Glucose and pharmacological modulators of ATP-sensitive K+ channels control [Ca2+]c by different mechanisms in isolated mouse alpha-cellsChanneling dysglycemia: ion-channel variations perturbing glucose homeostasis.Insulin as a physiological modulator of glucagon secretion.Inhibitory effects of leptin on pancreatic alpha-cell function.Benefits and limitations of reducing glucagon action for the treatment of type 2 diabetes.Role of KATP channels in glucose-regulated glucagon secretion and impaired counterregulation in type 2 diabetes.Beta-cell-mediated signaling predominates over direct alpha-cell signaling in the regulation of glucagon secretion in humansCentral insulin and leptin-mediated autonomic control of glucose homeostasis.Modeling the pancreatic α-cell: dual mechanisms of glucose suppression of glucagon secretion.Functional identification of islet cell types by electrophysiological fingerprinting.The role of the KATP channel in glucose homeostasis in health and disease: more than meets the islet.The metabolic actions of glucagon revisited
P2860
Q21129250-FA800803-6D8E-4FBD-A1C5-DC623FA381E4Q24648821-CEB6DBEE-30DE-4C6F-B349-31B8E84AE81DQ26269929-1ECBB0DC-AA58-4A98-B3B9-91E804017C94Q26795437-8BDABF00-9797-42D4-91F1-FAB4C603CC13Q27027920-158E864F-373B-445E-AB74-ACE5B558D4F5Q28511272-F43BD568-198D-452C-A5ED-9334233871ACQ30243992-3F592B82-BEB3-4360-AEB9-522441A08018Q30370626-1737CAC4-487E-4393-963A-CEEEA17C1D02Q33556463-91F11F81-8A9C-41FF-A538-C3F5D84492F5Q33625684-7ABDD39B-FD79-47D5-8304-29F865526A79Q33671461-6E95BF85-521D-4BDD-A256-DE1C02FB7622Q33825190-9AC4FD0A-0563-4FE4-927B-4280E6F5EF3FQ34193086-30318E7A-E9C4-48D9-B295-CCE2076AFFCEQ34272586-FFF9D65F-9D5F-47F0-A5A0-83560F16A2FCQ34450543-4CC276C2-0BE1-4374-A290-72B4028889F8Q34545472-1BE6E283-78C1-46D3-BAD8-452CE51D1C34Q34718921-E2A4F6EF-C9E4-407B-A318-D41333C3ACD3Q35118797-57E71242-FD86-43EB-A279-FE445A85B521Q35555683-5672CBE0-C991-4DD1-8FE6-88F8F29C003AQ36197966-AF74D805-B481-41FC-B20A-E42E39DFEE46Q36394674-6F964696-D3B1-407C-B7A3-5E457967ABE9Q36516806-87EB3DBF-273F-4D4F-A961-841599C2D61EQ36796078-A1DEC738-C624-4620-AB8D-49B4F325462CQ36796117-4AC69EA9-F2EE-4A7F-8774-2F839F7B882AQ36810781-410430BF-1FC9-45BE-B127-CEC19BD552CDQ36837309-37617D64-BE87-4386-9B5B-3B2B524181BCQ36954492-197BCC14-843A-4779-9DCB-C0200E927B91Q37066901-B343187D-F5ED-40FB-85DC-6A86AB348770Q37066906-A83D5AD8-3EE4-40C6-96E3-E4AE0FD3D50CQ37069807-902BBA36-0ECD-4967-93FB-0E97DD233C86Q37224066-1ADB2246-D2FB-4F5C-A535-AC33CC846612Q37236295-2EC8B8EE-F19A-4710-80B5-5BDD122D90F5Q37360316-AE46AC15-9025-44F2-B23D-CA3D3904E349Q37365285-8CE77C97-A678-4DC0-A741-B2C146C69252Q37437167-8EFA56EB-338F-4E71-8700-677B73190411Q37499206-EB07F917-F954-42FB-891C-46D810CC19A7Q37621734-FDDB929B-AE59-4A2D-BF96-4F8EE2EECFB3Q37735475-D4B6DCC7-CBF7-4A28-B483-651330F92010Q37762333-1DAAC28F-4E9E-4467-9196-C2B997E61909Q37801277-DEBAF777-83BA-4BE3-92FF-3F603EC319B3
P2860
A K ATP channel-dependent pathway within alpha cells regulates glucagon release from both rodent and human islets of Langerhans.
description
2007 nî lūn-bûn
@nan
2007 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
name
A K ATP channel-dependent path ...... nd human islets of Langerhans.
@ast
A K ATP channel-dependent path ...... nd human islets of Langerhans.
@en
type
label
A K ATP channel-dependent path ...... nd human islets of Langerhans.
@ast
A K ATP channel-dependent path ...... nd human islets of Langerhans.
@en
prefLabel
A K ATP channel-dependent path ...... nd human islets of Langerhans.
@ast
A K ATP channel-dependent path ...... nd human islets of Langerhans.
@en
P2093
P2860
P50
P1433
P1476
A K ATP channel-dependent path ...... and human islets of Langerhans
@en
P2093
Paul R V Johnson
Reshma Ramracheya
Xiaosong Ma
Yang Zhang De Marinis
P2860
P356
10.1371/JOURNAL.PBIO.0050143
P407
P577
2007-06-01T00:00:00Z