Enantioselective synthesis of the complex rocaglate (-)-silvestrol.
about
Discovery of natural product anticancer agents from biodiverse organismsDiscovery of new anticancer agents from higher plantsDiscovery of Anticancer Agents of Diverse Natural OriginAntitumor activity and mechanism of action of the cyclopenta[b]benzofuran, silvestrolBiomimetic photocycloaddition of 3-hydroxyflavones: synthesis and evaluation of rocaglate derivatives as inhibitors of eukaryotic translation.Isolation and characterization of minor analogues of silvestrol and other constituents from a large-scale re-collection of Aglaia foveolata.The continuing search for antitumor agents from higher plantsRocaglamide, silvestrol and structurally related bioactive compounds from Aglaia speciesPotential of plant-derived natural products in the treatment of leukemia and lymphomaSynthesis of rocaglamide hydroxamates and related compounds as eukaryotic translation inhibitors: synthetic and biological studiesChemistry and biology of rocaglamides (= flavaglines) and related derivatives from aglaia species (meliaceae)Eukaryotic initiation factor 4F: a vulnerability of tumor cells.ESIPT-mediated photocycloadditions of 3-hydroxyquinolinones: development of a fluorescence quenching assay for reaction screening.The relevance of higher plants in lead compound discovery programs.Characterization of silvestrol pharmacokinetics in mice using liquid chromatography-tandem mass spectrometry.Total synthesis of (±)-rocaglamide via oxidation-initiated Nazarov cyclization.Emerging therapeutics targeting mRNA translationTargeting the eIF4A RNA helicase blocks translation of the MUC1-C oncoprotein.Translation Inhibition by Rocaglates Is Independent of eIF4E Phosphorylation Status.Enantioselective photocycloaddition of 3-hydroxyflavones: total syntheses and absolute configuration assignments of (+)-ponapensin and (+)-elliptifolineCytotoxic Rocaglate Derivatives from Leaves of Aglaia perviridis.Bioactive flavaglines and other constituents isolated from Aglaia perviridis.Silvestrol exhibits significant in vivo and in vitro antileukemic activities and inhibits FLT3 and miR-155 expressions in acute myeloid leukemia.The novel plant-derived agent silvestrol has B-cell selective activity in chronic lymphocytic leukemia and acute lymphoblastic leukemia in vitro and in vivoEvidence for a functionally relevant rocaglamide binding site on the eIF4A-RNA complex.Discovery of anticancer agents of diverse natural origin.Photochemical reactions as key steps in natural product synthesis.Inhibitors of translation initiation as cancer therapeutics.Simplified silvestrol analogues with potent cytotoxic activity.Synthesis of Aza-Rocaglates via ESIPT-Mediated (3+2) Photocycloaddition(3+2)-Cycloaddition Reactions of Oxyallyl Cations.Towards Tartaric-Acid-Derived Asymmetric Organocatalysts.The Evolution of the Total Synthesis of Rocaglamide.Rocaglates as dual-targeting agents for experimental cerebral malaria.Enantioselective synthesis of cyclopenta[b]benzofurans via an organocatalytic intramolecular double cyclization.
P2860
Q24605488-6FA8BDDC-1179-41C5-B46E-B4D960427107Q27006814-0AFDF029-F1EA-4389-AE27-6C12E85208FAQ28068341-85F1DEED-B510-46B9-A804-55F8CF3EA3DFQ28475419-7CFE5211-039F-4EDA-92BC-0A7412D1F7B6Q33649987-CF77C33E-A1F6-4307-BDAA-646427630041Q33715653-A4E35B1F-D9B2-4EE1-9233-C71DF1F74D94Q33717343-90CC6299-588B-477D-AAD7-A79957B0DE55Q33881471-BB74DE8C-C618-42CA-871C-BF3491671AE1Q33942845-1CB5ACCF-4089-4ECA-B94F-FDDB86780AE6Q34086622-EA999DBD-5C54-43D2-B392-0D373172AD6FQ34207395-93980E95-C9FD-4B0A-955C-3B6AB008795EQ34240544-976D4084-9815-49A3-ACC1-B4E2083412C3Q34663277-C9D075F0-1B57-44E7-931E-08F78D1306F2Q35172533-B6550226-4AA6-4A88-9BCC-2643BED0A583Q35176880-0255FD1C-BB5C-4F2C-A0F4-431E15626993Q35836917-2EF95E16-6B21-402F-A9C5-CE6D9DE40936Q35853794-716901B1-3053-4614-8A42-0B8B58CC8AE8Q36237322-201EE14D-CC7F-4C31-BA28-31C8C1A8D9C0Q36447578-A5B3AF64-764A-48F7-9B3A-6649383D3B1EQ36485686-5BE3FF7F-0040-4EA8-9862-36FF2CE4861AQ36512335-B574210E-95BC-475C-8BEF-721DBDACC05CQ36711394-B04C84BB-AAF9-455F-A361-94AA1C8809D0Q36758390-D62F4E2B-1072-47BC-AB42-D3432524B0B6Q37187540-D4039D8F-AD0F-45AC-ACC0-B646E76C3975Q37228485-502D8E6B-E44C-4C93-AA6C-3845FBB02569Q37394746-0F659B9A-E0CF-4A5F-8E24-1BF1938E2AFAQ37829992-A361BDA2-09C5-445C-9AA3-96009D60EC0BQ37855822-BBDF6743-500C-4B29-80E2-CED70DF8FE2AQ39010685-C827EDB3-31DA-4C50-81FF-0005A0248ED3Q41161750-470BA72E-3055-4A47-AC28-46860EFC326AQ41813242-F1432614-C2E9-44E3-A58C-DEA7EEFA833CQ42029153-85AD4051-A802-4CCC-9EA7-E20F86925453Q48292393-00AA4859-A76D-4F21-BADF-39BC286375A9Q49790353-6ED74433-232F-48BB-8CD8-FB9D70125EEFQ52641518-9926BE2C-562A-492A-B928-B122EAF326C2
P2860
Enantioselective synthesis of the complex rocaglate (-)-silvestrol.
description
2007 nî lūn-bûn
@nan
2007 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
name
Enantioselective synthesis of the complex rocaglate (-)-silvestrol.
@ast
Enantioselective synthesis of the complex rocaglate (-)-silvestrol.
@en
Enantioselective synthesis of the complex rocaglate
@nl
type
label
Enantioselective synthesis of the complex rocaglate (-)-silvestrol.
@ast
Enantioselective synthesis of the complex rocaglate (-)-silvestrol.
@en
Enantioselective synthesis of the complex rocaglate
@nl
prefLabel
Enantioselective synthesis of the complex rocaglate (-)-silvestrol.
@ast
Enantioselective synthesis of the complex rocaglate (-)-silvestrol.
@en
Enantioselective synthesis of the complex rocaglate
@nl
P2093
P356
P1476
Enantioselective synthesis of the complex rocaglate (-)-silvestrol.
@en
P2093
Baudouin Gerard
Jerry Pelletier
John A Porco
Regina Cencic
P304
P356
10.1002/ANIE.200702707
P407
P577
2007-01-01T00:00:00Z