A novel alpha(v)beta (3)-blocking disintegrin containing the RGD motive, DisBa-01, inhibits bFGF-induced angiogenesis and melanoma metastasis.
about
Disintegrins from snake venoms and their applications in cancer research and therapy.Inhibition of αvβ3 integrin induces loss of cell directionality of oral squamous carcinoma cells (OSCC)A transcriptomic analysis of gene expression in the venom gland of the snake Bothrops alternatus (urutu).Functional analysis of a recombinant PIII-SVMP, GST-acocostatin; an apoptotic inducer of HUVEC and HeLa, but not SK-Mel-28 cellsIntegrin αvβ3-targeted gold nanoshells augment tumor vasculature-specific imaging and therapy.RAM, an RGDS analog, exerts potent anti-melanoma effects in vitro and in vivo.Programmable multivalent display of receptor ligands using peptide nucleic acid nanoscaffolds.Integrins and bone metastasis: integrating tumor cell and stromal cell interactions.cDNA cloning of a snake venom metalloproteinase from the eastern diamondback rattlesnake (Crotalus adamanteus), and the expression of its disintegrin domain with anti-platelet effects.Anti-angiogenic activities of two recombinant disintegrins derived from the Mohave and Prairie rattlesnakes.Development of a chimeric recombinant disintegrin as a cost-effective anti-cancer agent with promising translational potential.Recombinant disintegrin (r-Cam-dis) from Crotalus adamanteus inhibits adhesion of human pancreatic cancer cell lines to laminin-1 and vitronectin.Engagement of αIIbβ3 (GPIIb/IIIa) with ανβ3 integrin mediates interaction of melanoma cells with platelets: a connection to hematogenous metastasis.siRNA-mediated silencing of integrin β3 expression inhibits the metastatic potential of B16 melanoma cells.The effects of selected Australian snake venoms on tumour-associated microvascular endothelial cells (TAMECs) in vitro.Anti-invasive and anti-adhesive activities of a recombinant disintegrin, r-viridistatin 2, derived from the Prairie rattlesnake (Crotalus viridis viridis).Snake venom disintegrins and cell migration.Radioimmunotherapy for high-grade glioma.Recombinant disintegrin targets α(v) β(3) integrin and leads to mediator production.Priming Endothelial Cells With a Melanoma-Derived Extracellular Matrix Triggers the Activation of αvβ3/VEGFR2 Axis.Functional characterization of six aspartate (D) recombinant mojastin mutants (r-Moj): A second aspartate amino acid carboxyl to the RGD in r-Moj-D_ peptides is not sufficient to induce apoptosis of SK-Mel-28 cells.The anti-cancer potency and mechanism of a novel tumor-activated fused toxin, DLM.Tumour but not stromal expression of β3 integrin is essential, and is required early, for spontaneous dissemination of bone-metastatic breast cancer.Synthesis, characterization, and biological evaluation of (99m) Tc(CO)3 -labeled peptides for potential use as tumor targeted radiopharmaceuticals.Targeting Metastasis with Snake Toxins: Molecular Mechanisms.Effects of blocking αvβ3 integrin by a recombinant RGD disintegrin on remodeling of wound healing after induction of incisional hernia in rats.Effects of Blocking αvβ₃ integrin by a recombinant RGD disintegrin on remodeling of wound healing after induction of incisional hernia in rats.Recombinant and Chimeric Disintegrins in Preclinical Research
P2860
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P2860
A novel alpha(v)beta (3)-blocking disintegrin containing the RGD motive, DisBa-01, inhibits bFGF-induced angiogenesis and melanoma metastasis.
description
2007 nî lūn-bûn
@nan
2007 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
name
A novel alpha(v)beta (3)-block ...... nesis and melanoma metastasis.
@ast
A novel alpha(v)beta (3)-block ...... nesis and melanoma metastasis.
@en
A novel alpha(v)beta (3)-block ...... nesis and melanoma metastasis.
@nl
type
label
A novel alpha(v)beta (3)-block ...... nesis and melanoma metastasis.
@ast
A novel alpha(v)beta (3)-block ...... nesis and melanoma metastasis.
@en
A novel alpha(v)beta (3)-block ...... nesis and melanoma metastasis.
@nl
prefLabel
A novel alpha(v)beta (3)-block ...... nesis and melanoma metastasis.
@ast
A novel alpha(v)beta (3)-block ...... nesis and melanoma metastasis.
@en
A novel alpha(v)beta (3)-block ...... nesis and melanoma metastasis.
@nl
P2093
P2860
P1476
A novel alpha(v)beta (3)-block ...... nesis and melanoma metastasis.
@en
P2093
Arnaud Bonnefoy
Carmen L Salla Pontes
Chantal Legrand
Fabrice Chareyre
Heloisa S Selistre-de-Araujo
Iga Bechyne
Jan Manent
Marco Giovannini
Michel Crépin
Oscar H P Ramos
P2860
P2888
P356
10.1007/S10585-007-9101-Y
P577
2007-10-19T00:00:00Z
P5875
P6179
1030796467