Deletion of murine kininogen gene 1 (mKng1) causes loss of plasma kininogen and delays thrombosis
about
Misfolded proteins activate factor XII in humans, leading to kallikrein formation without initiating coagulationFuture prospects for contact factors as therapeutic targetsFactor XI and contact activation as targets for antithrombotic therapyA Novel Antithrombotic Mechanism Mediated by the Receptors of the Kallikrein/Kinin and Renin-Angiotensin SystemsMurine prolylcarboxypeptidase depletion induces vascular dysfunction with hypertension and faster arterial thrombosisA role for factor XIIa-mediated factor XI activation in thrombus formation in vivoUpregulation of tissue factor in monocytes by cleaved high molecular weight kininogen is dependent on TNF-alpha and IL-1betaCommon variants of large effect in F12, KNG1, and HRG are associated with activated partial thromboplastin time.From proteomic multimarker profiling to interesting proteins: thymosin-β(4) and kininogen-1 as new potential biomarkers for inflammatory hepatic lesions.Angiotensin II-mediated microvascular thrombosis.Reduced thrombosis in Klkb1-/- mice is mediated by increased Mas receptor, prostacyclin, Sirt1, and KLF4 and decreased tissue factorGenetic variation within the anticoagulant, procoagulant, fibrinolytic and innate immunity pathways as risk factors for venous thromboembolismThrombosis Prevention without Anticoagulation.Activation of the factor XII-driven contact system in Alzheimer's disease patient and mouse model plasma.Contact pathway of coagulation and inflammationDefective glycosylation of coagulation factor XII underlies hereditary angioedema type IIITranscriptional fingerprinting of "browning" white fat identifies NRG4 as a novel adipokine.Inhibition of polyphosphate as a novel strategy for preventing thrombosis and inflammation.Kininogen deficiency protects from ischemic neurodegeneration in mice by reducing thrombosis, blood-brain barrier damage, and inflammation.A comparison of the effects of factor XII deficiency and prekallikrein deficiency on thrombus formation.The elusive physiologic role of Factor XIIContact activation of kallikrein-kinin system by superparamagnetic iron oxide nanoparticles in vitro and in vivo.Physiological responses to protein aggregates: fibrinolysis, coagulation and inflammation (new roles for old factors).The many faces of the contact pathway and their role in thrombosis.Lessons from genome-wide association studies in venous thrombosis.Historical perspective and future direction of coagulation research.Current knowledge on the genetics of incident venous thrombosis.An essential role of high-molecular-weight kininogen in endotoxemia.The contact activation and kallikrein/kinin systems: pathophysiologic and physiologic activities.Antithrombotic potential of the contact activation pathway.The Intrinsic Pathway of Coagulation as a Target for Antithrombotic Therapy.Physiologic activities of the contact activation system.Interactions of β-amyloid peptide with fibrinogen and coagulation factor XII may contribute to Alzheimer's diseaseSelective depletion of plasma prekallikrein or coagulation factor XII inhibits thrombosis in mice without increased risk of bleeding.The Effects of the Contact Activation System on Hemorrhage.A complete factor XII deficiency does not affect coagulopathy, inflammatory responses, and lethality, but attenuates early hypotension in endotoxemic mice.Cleaved high molecular weight kininogen inhibits tube formation of endothelial progenitor cells via suppression of matrix metalloproteinase 2.Cleaved high-molecular-weight kininogen accelerates the onset of endothelial progenitor cell senescence by induction of reactive oxygen species.The extreme anterior domain is an essential craniofacial organizer acting through Kinin-Kallikrein signaling.Blood will out: vascular contributions to Alzheimer's disease.
P2860
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P2860
Deletion of murine kininogen gene 1 (mKng1) causes loss of plasma kininogen and delays thrombosis
description
2007 nî lūn-bûn
@nan
2007 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
name
Deletion of murine kininogen g ...... ininogen and delays thrombosis
@ast
Deletion of murine kininogen g ...... ininogen and delays thrombosis
@en
Deletion of murine kininogen gene 1
@nl
type
label
Deletion of murine kininogen g ...... ininogen and delays thrombosis
@ast
Deletion of murine kininogen g ...... ininogen and delays thrombosis
@en
Deletion of murine kininogen gene 1
@nl
prefLabel
Deletion of murine kininogen g ...... ininogen and delays thrombosis
@ast
Deletion of murine kininogen g ...... ininogen and delays thrombosis
@en
Deletion of murine kininogen gene 1
@nl
P2093
P2860
P1433
P1476
Deletion of murine kininogen g ...... ininogen and delays thrombosis
@en
P2093
Alvin H Schmaier
Ellen Barnes
Francis J Castellino
Guangbin Luo
Keith R McCrae
Sergei Merkulov
Takayuki Iwaki
Wan-Ming Zhang
Xincheng Lu
Yihua Zhou
P2860
P304
P356
10.1182/BLOOD-2007-06-092338
P407
P50
P577
2007-11-13T00:00:00Z