Protein phosphatase 2Cepsilon is an endoplasmic reticulum integral membrane protein that dephosphorylates the ceramide transport protein CERT to enhance its association with organelle membranes.
about
Acyl-CoA binding domain containing 3 (ACBD3) recruits the protein phosphatase PPM1L to ER-Golgi membrane contact sitesIntracellular trafficking of ceramide by ceramide transfer proteinCasein kinase I{gamma}2 down-regulates trafficking of ceramide in the synthesis of sphingomyelinChlamydia trachomatis co-opts GBF1 and CERT to acquire host sphingomyelin for distinct roles during intracellular developmentCrystal structure of the pleckstrin homology domain from the ceramide transfer protein: implications for conformational change upon ligand bindingN-Myristoylation is essential for protein phosphatases PPM1A and PPM1B to dephosphorylate their physiological substrates in cellsPhosphoregulation of the ceramide transport protein CERT at serine 315 in the interaction with VAMP-associated protein (VAP) for inter-organelle trafficking of ceramide in mammalian cells.Acute perturbations in Golgi organization impact de novo sphingomyelin synthesisAnalysis of the key elements of FFAT-like motifs identifies new proteins that potentially bind VAP on the ER, including two AKAPs and FAPP2.Signaling at the Golgi.A computational model of PKD and CERT interactions at the trans-Golgi network of mammalian cells.Goodpasture antigen-binding protein (GPBP) directs myofibril formation: identification of intracellular downstream effector 130-kDa GPBP-interacting protein (GIP130).Inactivation of ceramide transfer protein during pro-apoptotic stress by Golgi disassembly and caspase cleavage.Genomic profiling of multiple sequentially acquired tumor metastatic sites from an "exceptional responder" lung adenocarcinoma patient reveals extensive genomic heterogeneity and novel somatic variants driving treatment responseThe Golgi protein ACBD3, an interactor for poliovirus protein 3A, modulates poliovirus replicationRegulation of Golgi function via phosphoinositide lipids.Functional implications of sterol transport by the oxysterol-binding protein gene family.Signaling circuits on the Golgi complex.Regulation of Golgi signaling and trafficking by the KDEL receptor.Lipid landscapes and pipelines in membrane homeostasis.Sphingolipid metabolism and interorganellar transport: localization of sphingolipid enzymes and lipid transfer proteins.Multisite phosphorylation of oxysterol-binding protein regulates sterol binding and activation of sphingomyelin synthesis.PPM1l encodes an inositol requiring-protein 1 (IRE1) specific phosphatase that regulates the functional outcome of the ER stress response.Proteomics analysis of the nucleolus in adenovirus-infected cells.A functional genomic analysis of Arabidopsis thaliana PP2C clade D.Sphingolipid metabolismA model of OSBP-mediated cholesterol supply to Aichi virus RNA replication sites involving protein-protein interactions among viral proteins, ACBD3, OSBP, VAP-A/B, and SAC1.Targeted disruption of the mouse protein phosphatase ppm1l gene leads to structural abnormalities in the brain.CERTCERT:ceramidemultiphospho-CERT + PPM1L:VAPA/B => multiphospho-CERT:PPM1L:VAPA/Bmultiphospho-CERT:PPM1L:VAPA/B + 3 H2O => CERT:PPM1L:VAPA/B + 3 orthophosphateInteraction between the PH and START domains of ceramide transfer protein competes with phosphatidylinositol 4-phosphate binding by the PH domain.Selective targeting of collagen IV in the cancer cell microenvironment reduces tumor burden.
P2860
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P2860
Protein phosphatase 2Cepsilon is an endoplasmic reticulum integral membrane protein that dephosphorylates the ceramide transport protein CERT to enhance its association with organelle membranes.
description
2007 nî lūn-bûn
@nan
2007 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
name
Protein phosphatase 2Cepsilon ...... tion with organelle membranes.
@ast
Protein phosphatase 2Cepsilon ...... tion with organelle membranes.
@en
Protein phosphatase 2Cepsilon ...... tion with organelle membranes.
@nl
type
label
Protein phosphatase 2Cepsilon ...... tion with organelle membranes.
@ast
Protein phosphatase 2Cepsilon ...... tion with organelle membranes.
@en
Protein phosphatase 2Cepsilon ...... tion with organelle membranes.
@nl
prefLabel
Protein phosphatase 2Cepsilon ...... tion with organelle membranes.
@ast
Protein phosphatase 2Cepsilon ...... tion with organelle membranes.
@en
Protein phosphatase 2Cepsilon ...... tion with organelle membranes.
@nl
P2093
P2860
P356
P1476
Protein phosphatase 2Cepsilon ...... tion with organelle membranes.
@en
P2093
Hiroyuki Matsui
Keigo Kumagai
Kentaro Hanada
Miyuki Kawano
Nario Tomishige
Satoko Saito
Seishi Echigo
Shinri Tamura
Takayasu Kobayashi
P2860
P304
P356
10.1074/JBC.M707691200
P407
P577
2007-12-28T00:00:00Z