A transgenic Drosophila model demonstrates that the Helicobacter pylori CagA protein functions as a eukaryotic Gab adaptor.
about
Function, regulation and pathological roles of the Gab/DOS docking proteinsHelicobacter pylori-induced inflammation and epigenetic changes during gastric carcinogenesisDrosophila at the intersection of infection, inflammation, and cancerEchoes of a distant past: The cag pathogenicity island of Helicobacter pyloriPolymorphism in the Helicobacter pylori CagA and VacA toxins and diseaseHelicobacter pylori usurps cell polarity to turn the cell surface into a replicative nicheTransgenic expression of the Helicobacter pylori virulence factor CagA promotes apoptosis or tumorigenesis through JNK activation in DrosophilaOrder and disorder in large multi-site docking proteins of the Gab family--implications for signalling complex formation and inhibitor design strategiesHelicobacter pylori cytotoxin-associated gene A (CagA) subverts the apoptosis-stimulating protein of p53 (ASPP2) tumor suppressor pathway of the hostHelicobacter pylori perturbs iron trafficking in the epithelium to grow on the cell surfaceEffector prediction in host-pathogen interaction based on a Markov model of a ubiquitous EPIYA motif.Helicobacter pylori CagA disrupts epithelial patterning by activating myosin light chain.Use of larvae of the wax moth Galleria mellonella as an in vivo model to study the virulence of Helicobacter pylori.Mutual reinforcement of inflammation and carcinogenesis by the Helicobacter pylori CagA oncoprotein.Deconstructing host-pathogen interactions in Drosophila.J-Western forms of Helicobacter pylori cagA constitute a distinct phylogenetic group with a widespread geographic distribution.c-Src and c-Abl kinases control hierarchic phosphorylation and function of the CagA effector protein in Western and East Asian Helicobacter pylori strainsIdentification of genetic modifiers of CagA-induced epithelial disruption in DrosophilaHelicobacter pylori induces cancer cell motility independent of the c-Met receptor.Targeting focal adhesions:Helicobacter pylori-host communication in cell migration.Human pathogenic bacteria, fungi, and viruses in Drosophila: disease modeling, lessons, and shortcomings.Bacterial effectors: learning on the fly.Bacterial EPIYA effectors--where do they come from? What are they? Where are they going?The functional interplay of Helicobacter pylori factors with gastric epithelial cells induces a multi-step process in pathogenesis.Small flies to tackle big questions: assaying complex bacterial virulence mechanisms using Drosophila melanogaster.Exploiting the Gastric Epithelial Barrier: Helicobacter pylori's Attack on Tight and Adherens Junctions.Structure and function of Helicobacter pylori CagA, the first-identified bacterial protein involved in human cancer.Positive selection on a bacterial oncoprotein associated with gastric cancerCreation and Initial Characterization of Isogenic Helicobacter pylori CagA EPIYA Variants Reveals Differential Activation of Host Cell Signaling PathwaysA Tale of Two Toxins: Helicobacter Pylori CagA and VacA Modulate Host Pathways that Impact Disease.Gab docking proteins in cardiovascular disease, cancer, and inflammation.The bacterial virulence factor CagA induces microbial dysbiosis that contributes to excessive epithelial cell proliferation in the Drosophila gut.SseF, a type III effector protein from the mammalian pathogen Salmonella enterica, requires resistance-gene-mediated signalling to activate cell death in the model plant Nicotiana benthamiana.
P2860
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P2860
A transgenic Drosophila model demonstrates that the Helicobacter pylori CagA protein functions as a eukaryotic Gab adaptor.
description
2008 nî lūn-bûn
@nan
2008 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年学术文章
@wuu
2008年学术文章
@zh-cn
2008年学术文章
@zh-hans
2008年学术文章
@zh-my
2008年学术文章
@zh-sg
2008年學術文章
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name
A transgenic Drosophila model ...... s as a eukaryotic Gab adaptor.
@ast
A transgenic Drosophila model ...... s as a eukaryotic Gab adaptor.
@en
A transgenic Drosophila model ...... s as a eukaryotic Gab adaptor.
@nl
type
label
A transgenic Drosophila model ...... s as a eukaryotic Gab adaptor.
@ast
A transgenic Drosophila model ...... s as a eukaryotic Gab adaptor.
@en
A transgenic Drosophila model ...... s as a eukaryotic Gab adaptor.
@nl
prefLabel
A transgenic Drosophila model ...... s as a eukaryotic Gab adaptor.
@ast
A transgenic Drosophila model ...... s as a eukaryotic Gab adaptor.
@en
A transgenic Drosophila model ...... s as a eukaryotic Gab adaptor.
@nl
P2093
P2860
P1433
P1476
A transgenic Drosophila model ...... s as a eukaryotic Gab adaptor.
@en
P2093
Anica M Wandler
Crystal M Botham
Karen Guillemin
P2860
P304
P356
10.1371/JOURNAL.PPAT.1000064
P577
2008-05-16T00:00:00Z