Gambogic acid is an antagonist of antiapoptotic Bcl-2 family proteins.
about
Apogossypol derivatives as antagonists of antiapoptotic Bcl-2 family proteinsInhibition of Bfl-1 with N-aryl maleimides.Epistatic mutations in PUMA BH3 drive an alternate binding mode to potently and selectively inhibit anti-apoptotic Bfl-1Evaluation of the pharmacophoric motif of the caged Garcinia xanthonesHigh-throughput fluorescence polarization assay for chemical library screening against anti-apoptotic Bcl-2 family member Bfl-1.The synthetic caged garcinia xanthone cluvenone induces cell stress and apoptosis and has immune modulatory activity.Methyl jasmonate sensitizes human bladder cancer cells to gambogic acid-induced apoptosis through down-regulation of EZH2 expression by miR-101.Chemistry and biology of the caged Garcinia xanthones.Anti-cancer natural products isolated from chinese medicinal herbsThe mitochondrial death pathway: a promising therapeutic target in diseasesRecent research on bioactive xanthones from natural medicine: Garcinia hanburyi.Subcellular localization and activity of gambogic acidInhibition of inwardly rectifying Kir2.x channels by the novel anti-cancer agent gambogic acid depends on both pore block and PIP2 interference.A-ring oxygenation modulates the chemistry and bioactivity of caged Garcinia xanthones.Gambogic acid enhances proteasome inhibitor-induced anticancer activity.Gambogic acid induces apoptosis in diffuse large B-cell lymphoma cells via inducing proteasome inhibitionSynergetic effect of functional cadmium-tellurium quantum dots conjugated with gambogic acid for HepG2 cell-labeling and proliferation inhibitionTumor neovasculature-targeted cationic PEGylated liposomes of gambogic acid for the treatment of triple-negative breast cancerNovel Natural Product-like Caged Xanthones Bearing a Carbamate Moiety Exhibit Antitumor Potency and Anti-Angiogenesis Activity In vivo.BCL2A1: the underdog in the BCL2 family.Anti-leukemic, anti-lung, and anti-breast cancer potential of the microbial polyketide 2, 4-diacetylphloroglucinol (DAPG) and its interaction with the metastatic proteins than the antiapoptotic Bcl-2 proteins.Gambogic Acid and Its Role in Chronic Diseases.Natural compounds with P2X7 receptor-modulating properties.Gambogic acid promotes apoptosis and resistance to metastatic potential in MDA-MB-231 human breast carcinoma cells.Gambogic acid as a non-competitive inhibitor of ATP-binding cassette transporter B1 reverses the multidrug resistance of human epithelial cancers by promoting ATP-binding cassette transporter B1 protein degradation.Antitumor effects of novel compound, guttiferone K, on colon cancer by p21Waf1/Cip1-mediated G(0) /G(1) cell cycle arrest and apoptosis.Cluvenone induces apoptosis via a direct target in mitochondria: a possible mechanism to circumvent chemo-resistance?Direct visualization of Bcl-2 family protein interactions using live cell fluorescent protein redistribution assays.Gambogic acid is cytotoxic to cancer cells through inhibition of the ubiquitin-proteasome system.Folate-decorated arginine-based poly(ester urea urethane) nanoparticles as carriers for gambogic acid and effect on cancer cells.General pharmacological properties, developmental toxicity, and analgesic activity of gambogic acid, a novel natural anticancer agent.MCL-1 inhibition in cancer treatment
P2860
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P2860
Gambogic acid is an antagonist of antiapoptotic Bcl-2 family proteins.
description
2008 nî lūn-bûn
@nan
2008 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
Gambogic acid is an antagonist of antiapoptotic Bcl-2 family proteins.
@ast
Gambogic acid is an antagonist of antiapoptotic Bcl-2 family proteins.
@en
type
label
Gambogic acid is an antagonist of antiapoptotic Bcl-2 family proteins.
@ast
Gambogic acid is an antagonist of antiapoptotic Bcl-2 family proteins.
@en
prefLabel
Gambogic acid is an antagonist of antiapoptotic Bcl-2 family proteins.
@ast
Gambogic acid is an antagonist of antiapoptotic Bcl-2 family proteins.
@en
P2093
P2860
P1476
Gambogic acid is an antagonist of antiapoptotic Bcl-2 family proteins.
@en
P2093
Arnold C Satterthwait
Chaofang Jin
Chung-Wai Shiau
Dayong Zhai
John C Reed
Shinichi Kitada
P2860
P304
P356
10.1158/1535-7163.MCT-07-2373
P577
2008-06-01T00:00:00Z