Alterations in the intrinsic properties of the GPIbalpha-VWF tether bond define the kinetics of the platelet-type von Willebrand disease mutation, Gly233Val.
about
Crystal structure of the wild-type von Willebrand factor A1-glycoprotein Ibalpha complex reveals conformation differences with a complex bearing von Willebrand disease mutationsRegulation of L-selectin-dependent hydrodynamic shear thresholding by leukocyte deformability and shear dependent bond number.L-selectin shear thresholding modulates leukocyte secondary capture.Flow-enhanced adhesion regulated by a selectin interdomain hinge.Flow-induced structural transition in the beta-switch region of glycoprotein IbPlatelet glycoprotein Ibalpha forms catch bonds with human WT vWF but not with type 2B von Willebrand disease vWF.Flow induces loop-to-beta-hairpin transition on the beta-switch of platelet glycoprotein Ib alphaMultiscale prediction of patient-specific platelet function under flowThe mechanism of VWF-mediated platelet GPIbalpha binding.Kinetics of GPIbalpha-vWF-A1 tether bond under flow: effect of GPIbalpha mutations on the association and dissociation rates.Mechanics of transient platelet adhesion to von Willebrand factor under flowExploiting the kinetic interplay between GPIbα-VWF binding interfaces to regulate hemostasis and thrombosisTransport governs flow-enhanced cell tethering through L-selectin at threshold shear.Transport regulation of two-dimensional receptor-ligand associationExtracellular matrix proteins in hemostasis and thrombosisPlatelet adhesive dynamics. Part II: high shear-induced transient aggregation via GPIbalpha-vWF-GPIbalpha bridgingMechanisms for flow-enhanced cell adhesionThe N-terminal flanking region of the A1 domain regulates the force-dependent binding of von Willebrand factor to platelet glycoprotein Ibα.Rolling cell adhesionTransport physics and biorheology in the setting of hemostasis and thrombosis.Application of microfluidic devices in studies of thrombosis and hemostasis.Dynamic force spectroscopy of glycoprotein Ib-IX and von Willebrand factor.The Effect of Hematocrit on Platelet Adhesion: Experiments and Simulations.Multiscale model of platelet translocation and collision.P-selectin glycoprotein ligand-1 decameric repeats regulate selectin-dependent rolling under flow conditions.The snake venom protein botrocetin acts as a biological brace to promote dysfunctional platelet aggregation.Receptor-mediated cell mechanosensing.Specific electrostatic interactions between charged amino acid residues regulate binding of von Willebrand factor to blood platelets.Stochastic modeling of blood coagulation initiation.Examining platelet adhesion via Stokes flow simulations and microfluidic experiments.
P2860
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P2860
Alterations in the intrinsic properties of the GPIbalpha-VWF tether bond define the kinetics of the platelet-type von Willebrand disease mutation, Gly233Val.
description
2003 nî lūn-bûn
@nan
2003 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի մարտին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
Alterations in the intrinsic p ...... d disease mutation, Gly233Val.
@ast
Alterations in the intrinsic p ...... d disease mutation, Gly233Val.
@en
type
label
Alterations in the intrinsic p ...... d disease mutation, Gly233Val.
@ast
Alterations in the intrinsic p ...... d disease mutation, Gly233Val.
@en
prefLabel
Alterations in the intrinsic p ...... d disease mutation, Gly233Val.
@ast
Alterations in the intrinsic p ...... d disease mutation, Gly233Val.
@en
P2093
P1433
P1476
Alterations in the intrinsic p ...... d disease mutation, Gly233Val.
@en
P2093
Avril Lawshe
Gaurav Girdhar
Ian J Laurenzi
Jonathan L Miller
Scott L Diamond
Teresa A Doggett
Thomas G Diacovo
P304
P356
10.1182/BLOOD-2003-01-0072
P407
P577
2003-03-13T00:00:00Z