Fragment-based approach to drug lead discovery: overview and advances in various techniques.
about
Identification of Cys255 in HIF-1α as a novel site for development of covalent inhibitors of HIF-1α/ARNT PasB domain protein-protein interactionIdentification of purple acid phosphatase inhibitors by fragment-based screening: promising new leads for osteoporosis therapeuticsReview article: high-throughput affinity-based technologies for small-molecule drug discovery.A rapid oxime linker-based library approach to identification of bivalent inhibitors of the Yersinia pestis protein-tyrosine phosphatase, YopH.Targeting metalloproteins by fragment-based lead discovery.Design of a multi-purpose fragment screening library using molecular complexity and orthogonal diversity metrics.Inhibition of the insulin-like growth factor-1 receptor (IGF1R) tyrosine kinase as a novel cancer therapy approachNatural and synthetic inhibitors of kallikrein-related peptidases (KLKs).Streamlining hit discovery and optimization with a yoctoliter scale DNA reactor.Finding novel pharmaceuticals in the systems biology era using multiple effective drug targets, phenotypic screening and knowledge of transporters: where drug discovery went wrong and how to fix it.Replacing sulfa drugs with novel DHPS inhibitorsEvolutions in fragment-based drug design: the deconstruction-reconstruction approachFragment-based strategy for structural optimization in combination with 3D-QSAR.The significance of G protein-coupled receptor crystallography for drug discovery.Molecular Insights into the Fungus-Specific Serine/Threonine Protein Phosphatase Z1 in Candida albicansAnalysis of flavonoid-based pharmacophores that inhibit aggrecanases (ADAMTS-4 and ADAMTS-5) and matrix metalloproteinases through the use of topologically constrained peptide substrates.Fragment-based screening by biochemical assays: Systematic feasibility studies with trypsin and MMP12.Exploring of drug leads from diversity-oriented Michael-acceptor library derived from natural products.Catalytic activation of pre-substrates via dynamic fragment assembly on protein templates.
P2860
Q27674057-2B1B3571-5760-4C20-BCF8-DFBF0E2DC068Q27682112-FF4DAFD1-5B2A-4974-AA4D-339364B49EA8Q33509959-5CF36B3F-9A80-43B0-810A-32FE83A1B77DQ33547251-5CD2B855-9E2F-40F1-9256-536AF9DCEBC4Q33896509-880170DF-7601-48DA-B57A-64AF45B0D4B7Q33908733-A651CCDB-2E10-4FA6-92DE-91B9F4280B8FQ33925323-62A5B584-4876-4521-8E2E-B1CABF45BE17Q34457491-2EDB808E-6408-4027-A0AD-000F1B77D52CQ34616688-22F1957B-11F8-4481-8A4F-72B0F69FC4D5Q34646772-A9137B43-FACB-43C2-89A3-DBFE53F11992Q34823402-5AD2907C-9BDF-4D8F-B8E1-BAEB77061CCFQ35009555-07FE0387-EB04-469A-B134-ECE3BB474009Q35030073-452F429C-ED9C-4F8E-AD5C-56265D549B8EQ35264433-0BAA2EC8-B630-4D24-8D27-E1E0AD25465AQ37208359-E31563DF-6472-4D2E-92DE-DB3C8DDFCEC2Q37435339-4DCAC981-1A0A-4EA5-B2CF-6FBD76B34B68Q42882505-2E508959-7E57-4A0D-9E59-045407639685Q46096405-5ADED947-9E96-4021-A7FE-05ADC7CE689CQ52872220-83473B19-DD7F-4146-96E0-B15D0EBBCAB5
P2860
Fragment-based approach to drug lead discovery: overview and advances in various techniques.
description
2008 nî lūn-bûn
@nan
2008 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
Fragment-based approach to dru ...... dvances in various techniques.
@ast
Fragment-based approach to dru ...... dvances in various techniques.
@en
type
label
Fragment-based approach to dru ...... dvances in various techniques.
@ast
Fragment-based approach to dru ...... dvances in various techniques.
@en
prefLabel
Fragment-based approach to dru ...... dvances in various techniques.
@ast
Fragment-based approach to dru ...... dvances in various techniques.
@en
P1433
P1476
Fragment-based approach to dru ...... dvances in various techniques.
@en
P2093
Antonella Squarcia
Sandra Bartoli
P304
P356
10.2165/00126839-200809040-00002
P577
2008-01-01T00:00:00Z