Declining expression of a single epithelial cell-autonomous gene accelerates age-related thymic involution
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Deletion of FoxN1 in the thymic medullary epithelium reduces peripheral T cell responses to infection and mimics changes of agingInsights on FoxN1 biological significance and usages of the "nude" mouse in studies of T-lymphopoiesisFOXN1 in thymus organogenesis and developmentMorphogenesis and maintenance of the 3D thymic medulla and prevention of nude skin phenotype require FoxN1 in pre- and post-natal K14 epitheliumDecline of FOXN1 gene expression in human thymus correlates with age: possible epigenetic regulation.A Fine-Tune Role of Mir-125a-5p on Foxn1 During Age-Associated Changes in the Thymus.Regeneration of the aged thymus by a single transcription factor.Biological significance of FoxN1 gain-of-function mutations during T and B lymphopoiesis in juvenile mice.The aging immune system and its relationship with cancerOverexpression of Foxn1 attenuates age-associated thymic involution and prevents the expansion of peripheral CD4 memory T cellsThymic involution perturbs negative selection leading to autoreactive T cells that induce chronic inflammation.Young, proliferative thymic epithelial cells engraft and function in aging thymuses.Age-Related Disruption of Steady-State Thymic Medulla Provokes Autoimmune Phenotype via Perturbing Negative Selection.Thymus Size and Age-related Thymic Involution: Early Programming, Sexual Dimorphism, Progenitors and Stroma.Premature thymic involution is independent of structural plasticity of the thymic stroma.Aging induced decline in T-lymphopoiesis is primarily dependent on status of progenitor niches in the bone marrow and thymusFoxn1 maintains thymic epithelial cells to support T-cell development via mcm2 in zebrafish.Role of the p63-FoxN1 regulatory axis in thymic epithelial cell homeostasis during aging.FOXN1 in organ development and human diseases.Immune senescence: significance of the stromal microenvironment.Soluble antigens from the neurotropic pathogen Angiostrongylus cantonensis directly induce thymus atrophy in a mouse model.MicroRNAs Regulate Thymic Epithelium in Age-Related Thymic Involution via Down- or Upregulation of Transcription Factors.Capacity of tTreg generation is not impaired in the atrophied thymus.A novel Foxn1eGFP/+ mouse model identifies Bmp4-induced maintenance of Foxn1 expression and thymic epithelial progenitor populations.Modulation and the Underlying Mechanism of T Cells in Thymus of Mice by Oral Administration of Sodium Fluoride.
P2860
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P2860
Declining expression of a single epithelial cell-autonomous gene accelerates age-related thymic involution
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2010 nî lūn-bûn
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2010 թուականի Մարտին հրատարակուած գիտական յօդուած
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2010 թվականի մարտին հրատարակված գիտական հոդված
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2010年の論文
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2010年学术文章
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2010年学术文章
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2010年学术文章
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2010年学术文章
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2010年学术文章
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2010年學術文章
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name
Declining expression of a sing ...... age-related thymic involution
@ast
Declining expression of a sing ...... age-related thymic involution
@en
type
label
Declining expression of a sing ...... age-related thymic involution
@ast
Declining expression of a sing ...... age-related thymic involution
@en
prefLabel
Declining expression of a sing ...... age-related thymic involution
@ast
Declining expression of a sing ...... age-related thymic involution
@en
P2093
P2860
P1433
P1476
Declining expression of a sing ...... age-related thymic involution
@en
P2093
Dong-Ming Su
Jianfei Guo
Liguang Sun
Robert Brown
Takashi Amagai
P2860
P304
P356
10.1111/J.1474-9726.2010.00559.X
P577
2010-03-12T00:00:00Z