Development of an in vitro drug-drug interaction assay to simultaneously monitor five cytochrome P450 isoforms and performance assessment using drug library compounds.
about
Quantifying and predicting the promiscuity and isoform specificity of small-molecule cytochrome P450 inhibitors.A high-throughput inhibition screening of major human cytochrome P450 enzymes using an in vitro cocktail and liquid chromatography-tandem mass spectrometry.A Screen of Approved Drugs Identifies the Androgen Receptor Antagonist Flutamide and Its Pharmacologically Active Metabolite 2-Hydroxy-Flutamide as Heterotropic Activators of Cytochrome P450 3A In Vitro and In Vivo.Application of a cocktail approach to screen cytochrome P450 BM3 libraries for metabolic activity and diversity.High-Throughput Cytochrome P450 Cocktail Inhibition Assay for Assessing Drug-Drug and Drug-Botanical Interactions.Discovery of a Selective and CNS Penetrant Negative Allosteric Modulator of Metabotropic Glutamate Receptor Subtype 3 with Antidepressant and Anxiolytic Activity in Rodents.The Antimicrobial Agent Fusidic Acid Inhibits Organic Anion Transporting Polypeptide-Mediated Hepatic Clearance and May Potentiate Statin-Induced Myopathy.N-Alkylpyrido[1',2':1,5]pyrazolo-[4,3-d]pyrimidin-4-amines: A new series of negative allosteric modulators of mGlu1/5 with CNS exposure in rodents.Effect of health foods on cytochrome P450-mediated drug metabolism.A sensitive and specific CYP cocktail assay for the simultaneous assessment of human cytochrome P450 activities in primary cultures of human hepatocytes using LC-MS/MS.Octahydropyrrolo[3,4-c]pyrrole negative allosteric modulators of mGlu1.Discovery of VU0409106: A negative allosteric modulator of mGlu5 with activity in a mouse model of anxietyDiscovery of VU0431316: a negative allosteric modulator of mGlu5 with activity in a mouse model of anxiety.In vitro ADME profiling using high-throughput rapidfire mass spectrometry: cytochrome p450 inhibition and metabolic stability assays.Development of a high-speed, multiplexed sample-delivery instrument for LC-MS/MS bioanalysis.Discovery of N-(5-Fluoropyridin-2-yl)-6-methyl-4-(pyrimidin-5-yloxy)picolinamide (VU0424238): A Novel Negative Allosteric Modulator of Metabotropic Glutamate Receptor Subtype 5 Selected for Clinical Evaluation."Drugs on oxygen": an update and perspective on the role of cytochrome P450 testing in pharmacology.Azole antifungal inhibition of buprenorphine, methadone and oxycodone in vitro metabolism.
P2860
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P2860
Development of an in vitro drug-drug interaction assay to simultaneously monitor five cytochrome P450 isoforms and performance assessment using drug library compounds.
description
2008 nî lūn-bûn
@nan
2008 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
Development of an in vitro dru ...... using drug library compounds.
@ast
Development of an in vitro dru ...... using drug library compounds.
@en
type
label
Development of an in vitro dru ...... using drug library compounds.
@ast
Development of an in vitro dru ...... using drug library compounds.
@en
prefLabel
Development of an in vitro dru ...... using drug library compounds.
@ast
Development of an in vitro dru ...... using drug library compounds.
@en
P2093
P1476
Development of an in vitro dru ...... using drug library compounds.
@en
P2093
Archie Thurston
Caroline Lee
Danielle Smith
Douglas Burdette
Howard Miller
Lance Heinle
Mary Beth Dunklee
Michael Zientek
Odette Fahmi
Ruth Hyland
P304
P356
10.1016/J.VASCN.2008.05.131
P577
2008-06-25T00:00:00Z