Notch and presenilin regulate cellular expansion and cytokine secretion but cannot instruct Th1/Th2 fate acquisition
about
Skin-derived TSLP triggers progression from epidermal-barrier defects to asthmaAtaxin-1 and Brother of ataxin-1 are components of the Notch signalling pathwayCutting edge: Type I IFN reverses human Th2 commitment and stability by suppressing GATA3Role of Notch signaling in regulating innate immunity and inflammation in health and diseaseEarly signaling events that underlie fate decisions of naive CD4(+) T cells toward distinct T-helper cell subsetsActivated Notch1 target genes during embryonic cell differentiation depend on the cellular context and include lineage determinants and inhibitorsThe differential expression of IL-4 and IL-13 and its impact on type-2 immunityGamma-secretase composed of PS1/Pen2/Aph1a can cleave notch and amyloid precursor protein in the absence of nicastrinThe canonical Notch signaling pathway: unfolding the activation mechanism.Differentiation of effector CD4 T cell populations (*)T cell factor 1 initiates the T helper type 2 fate by inducing the transcription factor GATA-3 and repressing interferon-gamma.Presenilin 2 is the predominant γ-secretase in microglia and modulates cytokine releasePresenilin/gamma-Secretase and Inflammation.Mutant presenilin-1 deregulated peripheral immunity exacerbates Alzheimer-like pathologyRedundant Notch1 and Notch2 signaling is necessary for IFNγ secretion by T helper 1 cells during infection with Leishmania major.Notch signaling at later stages of NK cell development enhances KIR expression and functional maturationNotch ligand delta-like 4 regulates development and pathogenesis of allergic airway responses by modulating IL-2 production and Th2 immunity.Notch signaling regulates antigen sensitivity of naive CD4+ T cells by tuning co-stimulation.Genetic and functional evidence implicating DLL1 as the gene that influences susceptibility to visceral leishmaniasis at chromosome 6q27.Notch signal suppresses Toll-like receptor-triggered inflammatory responses in macrophages by inhibiting extracellular signal-regulated kinase 1/2-mediated nuclear factor κB activation.Mind bomb-1 in dendritic cells is specifically required for Notch-mediated T helper type 2 differentiation.Notch system in the linkage of innate and adaptive immunity.Notch controls the magnitude of T helper cell responses by promoting cellular longevity.Real-time imaging of notch activation with a luciferase complementation-based reporter.Hippocampal expression of murine IL-4 results in exacerbation of amyloid depositionNotch signal strength controls cell fate in the haemogenic endotheliumDistinct TCR signaling pathways drive proliferation and cytokine production in T cellsCytokines of the γ(c) family control CD4+ T cell differentiation and function.Notch signaling regulates T cell accumulation and function in the central nervous system during experimental autoimmune encephalomyelitis.Notch simultaneously orchestrates multiple helper T cell programs independently of cytokine signals.Notch signaling in acute promyelocytic leukemiaHow are T(H)1 and T(H)2 effector cells made?Non-Canonical Notch Signaling Drives Activation and Differentiation of Peripheral CD4(+) T Cells.Notch signaling in the hematopoietic system.STAT5-induced lunatic fringe during Th2 development alters delta-like 4-mediated Th2 cytokine production in respiratory syncytial virus-exacerbated airway allergic diseaseDifferential requirements for IL-4/STAT6 signalling in CD4 T-cell fate determination and Th2-immune effector responses.Canonical and non-canonical Notch ligands.Current understanding of Th2 cell differentiation and function'All things considered': transcriptional regulation of T helper type 2 cell differentiation from precursor to effector activation.Targeting the Notch Pathway to Prevent Rejection.
P2860
Q21145827-E1F49189-62CE-4467-8996-EC97FC0D793AQ24299218-88F57588-22F4-43BF-B0AE-2D94469CC4B4Q24322775-607C62F1-D243-4C11-BAEE-4654AB670890Q26764946-F88266DD-AE61-4D35-BAE2-1A2017821CEDQ27026592-FE66ADB2-D3AD-40A3-949A-82FF3D6FB908Q27324100-1FDF08F5-5541-45E3-BFF4-093842D8FF96Q28083968-8A56C08F-CFD0-44BE-BBDD-4749320F4626Q28595013-3113AE0A-C984-4877-8287-7151E33D0374Q29547725-35467F09-EC8A-45F1-B716-76C77DB82B1EQ29614838-80D67254-BE2E-417E-A3E2-51342C0E2ED6Q33666789-A44BA934-8417-4347-978E-4DD95838C036Q33785755-CA98D127-FE33-4AEA-8B58-DC256A642094Q33918695-DA047F10-2061-4077-B1D3-FFA08F8E79FAQ33935822-5B678AE8-F827-4EB3-8A8B-9311CB2B5782Q34186971-3036EFEA-C46B-4CE8-97DD-6730A483F6DDQ34218967-D0D686AA-714A-42BF-88EB-990B3DF17F12Q34306829-C7D73D44-3FDF-4FF3-BA49-D14D049C424BQ35041145-968B2A83-3BFF-4D4A-910F-30CB89847640Q35093302-BBFC5B9C-8100-489A-94BE-95970DC7A256Q35838949-B9CA2EA7-92CE-4AC2-98D9-C3E3C27D7575Q35918324-14886169-11E8-463B-B5D4-64992657DE27Q36055999-58BC3307-FB89-4460-A51B-26A847736C09Q36061611-053C2B94-50B0-4069-B231-E3CD10E1EC04Q36071418-915E1EA5-3580-465A-B89B-0E1779C9A541Q36232140-E95E92F8-5A0E-40C3-8E61-8394980817D5Q36251250-D8D84C13-86D9-4C42-ABB8-9008C8E99FA0Q36625346-7DF834B5-376D-4DC1-9DBA-DE4C60EB1C80Q36781465-D1DF4EEB-7573-4FC4-8CAF-09CEEBC2FEECQ37075692-6B16E9CB-9D17-4311-954C-3C6E02C038FEQ37146430-4428317B-B0B7-4BB3-8F56-6CD82E600CC5Q37414175-87DFA0EA-8E0C-41BF-AADD-6CCF918FB492Q37449444-0BDEFF33-0C57-4FC8-A5E5-F04966932692Q37578833-CDA7C15A-95E4-46AF-96DD-A6A8A61AAFD0Q37594765-E78599C2-9266-4E32-8575-8F2BF9D8A721Q37625393-5DB0CAFE-7BA4-4E7B-B958-0F093F1E64BBQ37654752-E0CFAB0B-EF24-4079-BA29-38F510BECA6BQ37785194-5D3A4453-9B31-423C-B6B6-CA36DACA48DDQ37929655-21C097DA-B87B-447D-AF83-83C51EABA939Q38106128-883F4C18-54C1-4F93-A37D-E533D52C4B41Q38796193-BF28C9C6-F445-42AD-850A-2C1480BC36D2
P2860
Notch and presenilin regulate cellular expansion and cytokine secretion but cannot instruct Th1/Th2 fate acquisition
description
2008 nî lūn-bûn
@nan
2008 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
Notch and presenilin regulate ...... truct Th1/Th2 fate acquisition
@ast
Notch and presenilin regulate ...... truct Th1/Th2 fate acquisition
@en
type
label
Notch and presenilin regulate ...... truct Th1/Th2 fate acquisition
@ast
Notch and presenilin regulate ...... truct Th1/Th2 fate acquisition
@en
prefLabel
Notch and presenilin regulate ...... truct Th1/Th2 fate acquisition
@ast
Notch and presenilin regulate ...... truct Th1/Th2 fate acquisition
@en
P2860
P1433
P1476
Notch and presenilin regulate ...... truct Th1/Th2 fate acquisition
@en
P2093
John R Sedy
Kenneth M Murphy
P2860
P356
10.1371/JOURNAL.PONE.0002823
P407
P577
2008-07-30T00:00:00Z