Somatic mutation leads to efficient affinity maturation when centrocytes recycle back to centroblasts.
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IgVH genes from different anatomical regions, with different histopathological patterns, of a rheumatoid arthritis patient suggest cyclic re-entry of mature synovial B-cells in the hypermutation processChemotaxis in densely populated tissue determines germinal center anatomy and cell motility: a new paradigm for the development of complex tissuesOptimal germinal center B cell activation and T-dependent antibody responses require expression of the mouse complement receptor Cr1Getting started in computational immunologyGerminal center dynamics revealed by multiphoton microscopy with a photoactivatable fluorescent reporter.Deriving a germinal center lymphocyte migration model from two-photon data.Optimality of mutation and selection in germinal centers.Strategies to guide the antibody affinity maturation processTrade-offs in antibody repertoires to complex antigensOptimal Sequential Immunization Can Focus Antibody Responses against Diversity Loss and Distraction.A one-shot germinal center model under protein structural stability constraintsTFH cells progressively differentiate to regulate the germinal center response.Computational Model Reveals Limited Correlation between Germinal Center B-Cell Subclone Abundancy and Affinity: Implications for Repertoire SequencingClonal and cellular dynamics in germinal centers.Germinal Center B Cell Dynamics.The Role of c-MYC in B-Cell Lymphomas: Diagnostic and Molecular AspectsHow germinal centers evolve broadly neutralizing antibodies: the breadth of the follicular helper T cell response.A Population Dynamics Model for Clonal Diversity in a Germinal Center.Germinal center reaction: antigen affinity and presentation explain it all.Activated germinal centre B cells undergo directed migration.Manipulating the selection forces during affinity maturation to generate cross-reactive HIV antibodies.Clonal selection in the germinal centre by regulated proliferation and hypermutation.Dynamic signaling by T follicular helper cells during germinal center B cell selection.Simulation of B cell affinity maturation explains enhanced antibody cross-reactivity induced by the polyvalent malaria vaccine AMA1.The proto-oncogene MYC is required for selection in the germinal center and cyclic reentry.MicroRNA-155 controls affinity-based selection by protecting c-MYC+ B cells from apoptosis.Role of framework mutations and antibody flexibility in the evolution of broadly neutralizing antibodies.PTEN-Regulated AID Transcription in Germinal Center B Cells Is Essential for the Class-Switch Recombination and IgG Antibody Responses.Cell Cycle-Associated CXCR4 Expression in Germinal Center B Cells and Its Implications on Affinity Maturation.A mechanism of T cell dependent selection of antigen engaged Germinal Center B cells
P2860
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P2860
Somatic mutation leads to efficient affinity maturation when centrocytes recycle back to centroblasts.
description
1997 nî lūn-bûn
@nan
1997 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
1997 թվականի հունիսին հրատարակված գիտական հոդված
@hy
1997年の論文
@ja
1997年論文
@yue
1997年論文
@zh-hant
1997年論文
@zh-hk
1997年論文
@zh-mo
1997年論文
@zh-tw
1997年论文
@wuu
name
Somatic mutation leads to effi ...... recycle back to centroblasts.
@ast
Somatic mutation leads to effi ...... recycle back to centroblasts.
@en
type
label
Somatic mutation leads to effi ...... recycle back to centroblasts.
@ast
Somatic mutation leads to effi ...... recycle back to centroblasts.
@en
prefLabel
Somatic mutation leads to effi ...... recycle back to centroblasts.
@ast
Somatic mutation leads to effi ...... recycle back to centroblasts.
@en
P1476
Somatic mutation leads to effi ...... s recycle back to centroblasts
@en
P2093
P304
P407
P577
1997-06-01T00:00:00Z