Complete deficiency in ADAMTS13 is prothrombotic, but it alone is not sufficient to cause thrombotic thrombocytopenic purpura.
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Pathophysiology of thrombotic thrombocytopenic purpuraProteolytic processing of von Willebrand factor by adamts13 and leukocyte proteasesAnimal models for thrombotic thrombocytopenic purpuraHepatic stellate cell damage may lead to decreased plasma ADAMTS13 activity in ratsCarboxyl terminus of ADAMTS13 directly inhibits platelet aggregation and ultra large von Willebrand factor string formation under flow in a free-thiol-dependent manner.Plasma ADAMTS-13 levels and the risk of myocardial infarction: an individual patient data meta-analysis.ADAMTS13 and microvascular thrombosisAn IAP retrotransposon in the mouse ADAMTS13 gene creates ADAMTS13 variant proteins that are less effective in cleaving von Willebrand factor multimers.Thrombotic thrombocytopenic purpura: a thrombotic disorder caused by ADAMTS13 deficiencyPrevalence of the ADAMTS-13 missense mutation R1060W in late onset adult thrombotic thrombocytopenic purpura.The combined roles of ADAMTS13 and VWF in murine models of TTP, endotoxemia, and thrombosis.Degradation of circulating von Willebrand factor and its regulator ADAMTS13 implicates secreted Bacillus anthracis metalloproteases in anthrax consumptive coagulopathy.The kidney in thrombotic thrombocytopenic purpura.Effect of prophylactic cyclosporine therapy on ADAMTS13 biomarkers in patients with idiopathic thrombotic thrombocytopenic purpuraCorrection of ADAMTS13 deficiency by in utero gene transfer of lentiviral vector encoding ADAMTS13 genes.The distal carboxyl-terminal domains of ADAMTS13 are required for regulation of in vivo thrombus formation.Correction of murine ADAMTS13 deficiency by hematopoietic progenitor cell-mediated gene therapyThe role of endothelial cell injury in thrombotic microangiopathy.Advances in our understanding of the pathogenesis of glomerular thrombotic microangiopathy.Natural history of Upshaw-Schulman syndrome based on ADAMTS13 gene analysis in Japan.Causes of thrombocytopenia in chronic hepatitis C viral infection.Thrombotic microangiopathy and associated renal disorders.AAV-mediated expression of an ADAMTS13 variant prevents shigatoxin-induced thrombotic thrombocytopenic purpuraCirculating endothelial cells and progenitors as prognostic factors during autoimmune thrombotic thrombocytopenic purpura: results of a prospective multicenter French study.ADAMTS13 Endopeptidase Protects against Vascular Endothelial Growth Factor Inhibitor-Induced Thrombotic Microangiopathy.Neutralization of inhibitory antibodies and restoration of therapeutic ADAMTS-13 activity levels in inhibitor-treated rats by the use of defined doses of recombinant ADAMTS-13.A novel role for von Willebrand factor in the pathogenesis of experimental cerebral malariaThrombotic thrombocytopenic purpura - analysis of clinical features, laboratory characteristics and therapeutic outcome of 24 patients treated at a Tertiary Care Center in Saudi Arabia.In vivo imaging analysis of the interaction between unusually large von Willebrand factor multimers and platelets on the surface of vascular wall.Plasminogen Tochigi mice exhibit phenotypes similar to wild-type mice under experimental thrombotic conditions.Cleavage of von Willebrand factor by granzyme M destroys its factor VIII binding capacity.von Willebrand factor self-association on platelet GpIbalpha under hydrodynamic shear: effect on shear-induced platelet activationExtracellular matrix proteins in hemostasis and thrombosisGeneration of Anti-Murine ADAMTS13 Antibodies and Their Application in a Mouse Model for Acquired Thrombotic Thrombocytopenic Purpura.Exacerbated venous thromboembolism in mice carrying a protein S K196E mutationADAMTS13: a new link between thrombosis and inflammation.Emerging Roles of ADAMTSs in Angiogenesis and Cancer.Von Willebrand Factor Abnormalities Studied in the Mouse Model: What We Learned about VWF Functions.SNPs in ADAMTS13.ADAMTS-13 regulates neutrophil recruitment in a mouse model of invasive pulmonary aspergillosis.
P2860
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P2860
Complete deficiency in ADAMTS13 is prothrombotic, but it alone is not sufficient to cause thrombotic thrombocytopenic purpura.
description
2005 nî lūn-bûn
@nan
2005 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
name
Complete deficiency in ADAMTS1 ...... otic thrombocytopenic purpura.
@ast
Complete deficiency in ADAMTS1 ...... otic thrombocytopenic purpura.
@en
type
label
Complete deficiency in ADAMTS1 ...... otic thrombocytopenic purpura.
@ast
Complete deficiency in ADAMTS1 ...... otic thrombocytopenic purpura.
@en
prefLabel
Complete deficiency in ADAMTS1 ...... otic thrombocytopenic purpura.
@ast
Complete deficiency in ADAMTS1 ...... otic thrombocytopenic purpura.
@en
P2093
P1433
P1476
Complete deficiency in ADAMTS1 ...... otic thrombocytopenic purpura.
@en
P2093
Fumiaki Banno
Hisashi Kato
Koichi Kokame
Shigeki Miyata
Shigenori Honda
Tomohiko Okuda
Toshiyuki Miyata
Yoshiaki Tomiyama
P304
P356
10.1182/BLOOD-2005-07-2765
P407
P577
2005-12-20T00:00:00Z