about
Computational enzyme design approaches with significant biological outcomes: progress and challengesJanus: Prediction and Ranking of Mutations Required for Functional Interconversion of EnzymesMolecular Determinants Underlying Binding Specificities of the ABL Kinase Inhibitors: Combining Alanine Scanning of Binding Hot Spots with Network Analysis of Residue Interactions and CoevolutionExploring Molecular Mechanisms of Paradoxical Activation in the BRAF Kinase Dimers: Atomistic Simulations of Conformational Dynamics and Modeling of Allosteric Communication Networks and Signaling Pathways.Mapping the mutual information network of enzymatic families in the protein structure to unveil functional features.Ensemble approach to predict specificity determinants: benchmarking and validationStructural and functional roles of coevolved sites in proteins.Comparing the functional roles of nonconserved sequence positions in homologous transcription repressors: implications for sequence/function analyses.Networks of high mutual information define the structural proximity of catalytic sites: implications for catalytic residue identification.New methods to measure residues coevolution in proteins.Determinants, discriminants, conserved residues--a heuristic approach to detection of functional divergence in protein familiesFunctionally important positions can comprise the majority of a protein's architecture.A coevolutionary residue network at the site of a functionally important conformational change in a phosphohexomutase enzyme family.Basis for substrate recognition and distinction by matrix metalloproteinasesDisentangling evolutionary signals: conservation, specificity determining positions and coevolution. Implication for catalytic residue predictionImproving the thermostability of alpha-amylase by combinatorial coevolving-site saturation mutagenesis.Prediction and redesign of protein-protein interactionsStructure-based Markov random field model for representing evolutionary constraints on functional sites.SPEER-SERVER: a web server for prediction of protein specificity determining sites.Computational Analysis of Residue Interaction Networks and Coevolutionary Relationships in the Hsp70 Chaperones: A Community-Hopping Model of Allosteric Regulation and CommunicationIntramolecular allosteric communication in dopamine D2 receptor revealed by evolutionary amino acid covariation.Correlated evolution of interacting proteins: looking behind the mirrortreeCorrelated positions in protein evolution and engineering.Role of sequence evolution and conformational dynamics in the substrate specificity and oligomerization mode of thymidylate kinases.Surface energetics and protein-protein interactions: analysis and mechanistic implications.New Measurement for Correlation of Co-evolution Relationship of Subsequences in Protein.Protein sites with more coevolutionary connections tend to evolve slower, while more variable protein families acquire higher coevolutionary connections.New measurement for correlation of co-evolution relationship of subsequences in protein.Identification of subfamily-specific sites based on active sites modeling and clustering.Reliable and robust detection of coevolving protein residues.Recognition of sites of functional specialisation in all known eukaryotic protein kinase families.Comparative analysis of sequence covariation methods to mine evolutionary hubs: examples from selected GPCR families.
P2860
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P2860
description
2009 nî lūn-bûn
@nan
2009 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
Coevolution in defining the functional specificity.
@ast
Coevolution in defining the functional specificity.
@en
type
label
Coevolution in defining the functional specificity.
@ast
Coevolution in defining the functional specificity.
@en
prefLabel
Coevolution in defining the functional specificity.
@ast
Coevolution in defining the functional specificity.
@en
P2860
P356
P1433
P1476
Coevolution in defining the functional specificity.
@en
P2093
Anna R Panchenko
Saikat Chakrabarti
P2860
P304
P356
10.1002/PROT.22239
P407
P577
2009-04-01T00:00:00Z