Epac mediates PACAP-dependent long-term depression in the hippocampus. - Wikidata - awgldk - TriplyDB

Epac mediates PACAP-dependent long-term depression in the hippocampus.

Epac mediates PACAP-dependent long-term depression in the hippocampus.

http://www.wikidata.org/entity/Q33383710

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Human-specific histone methylation signatures at transcription start sites in prefrontal neurons Role of EPAC in cAMP-Mediated Actions in Adrenocortical Cells Repair of traumatic plasmalemmal damage to neurons and other eukaryotic cells Differential distribution of exchange proteins directly activated by cyclic AMP within the adult rat retina Epac2 induces synapse remodeling and depression and its disease-associated forms alter spines Recent advances in the discovery of small molecules targeting exchange proteins directly activated by cAMP (EPAC).Epac2-mediated dendritic spine remodeling: implications for disease.Divergent label-free cell phenotypic pharmacology of ligands at the overexpressed β₂-adrenergic receptors.Phosphodiesterase Inhibitors as a Therapeutic Approach to Neuroprotection and Repair.Viagra for your synapses: Enhancement of hippocampal long-term potentiation by activation of beta-adrenergic receptors.Small G protein signaling in neuronal plasticity and memory formation: the specific role of ras family proteins Both PKA and Epac pathways mediate N-acetylcysteine-induced Connexin43 preservation in rats with myocardial infarction Epac2 Mediates cAMP-Dependent Potentiation of Neurotransmission in the Hippocampus.Pituitary adenylate cyclase-activating peptide (PACAP) recruits low voltage-activated T-type calcium influx under acute sympathetic stimulation in mouse adrenal chromaffin cells Neurofibromatosis-1 heterozygosity impairs CNS neuronal morphology in a cAMP/PKA/ROCK-dependent manner Involvement of cAMP-guanine nucleotide exchange factor II in hippocampal long-term depression and behavioral flexibility.β-Adrenergic receptors stimulate interleukin-6 production through Epac-dependent activation of PKCδ/p38 MAPK signalling in neonatal mouse cardiac fibroblasts Epac Signaling Is Required for Cocaine-Induced Change in AMPA Receptor Subunit Composition in the Ventral Tegmental Area.NPY Y1 receptors differentially modulate GABAA and NMDA receptors via divergent signal-transduction pathways to reduce excitability of amygdala neurons.Regulating the ubiquitin/proteasome pathway via cAMP-signaling: neuroprotective potential Interaction of PACAP with Sonic hedgehog reveals complex regulation of the hedgehog pathway by PKA.The role of Epac proteins, novel cAMP mediators, in the regulation of immune, lung and neuronal function.Separate cyclic AMP sensors for neuritogenesis, growth arrest, and survival of neuroendocrine cells.Role of Epac in brain and heart.Proteolytic remodeling of the synaptic cell adhesion molecules (CAMs) by metzincins in synaptic plasticity.Guanine nucleotide exchange factor Epac2-dependent activation of the GTP-binding protein Rap2A mediates cAMP-dependent growth arrest in neuroendocrine cells.Pathways for plasmalemmal repair mediated by PKA, Epac, and cytosolic oxidation in rat B104 cells in vitro and rat sciatic axons ex vivo.Identification of EPAC (Exchange Protein Activated by cAMP) bioinformatically as a potential signalling biomarker in Cardiovascular Disease (CVD) and its molecular docking by a lead molecule.Synaptic plasticity through activation of GluA3-containing AMPA-receptors.The Epac-Phospholipase Cε Pathway Regulates Endocannabinoid Signaling and Cocaine-Induced Disinhibition of Ventral Tegmental Area Dopamine Neurons.Pituitary adenylate cyclase-activating polypeptide (PACAP) inhibits the slow afterhyperpolarizing current sIAHP in CA1 pyramidal neurons by activating multiple signaling pathways.Bidirectional synaptic plasticity and spatial memory flexibility require Ca2+-stimulated adenylyl cyclases.Melatonin attenuates scopolamine-induced memory/synaptic disorder by rescuing EPACs/miR-124/Egr1 pathway.EPAC signalling pathways are involved in low PO2 chemoreception in carotid body chemoreceptor cells.An alternate cAMP pathway Epac promotes hippocampal long-term depression.Protein kinase Cɛ activity regulates mGluR5 surface expression in the rat nucleus accumbens.Stress peptide PACAP engages multiple signaling pathways within the carotid body to initiate excitatory responses in respiratory and sympathetic chemosensory afferents.Intracellular cAMP Sensor EPAC: Physiology, Pathophysiology, and Therapeutics Development.Orexin A regulates plasma insulin and leptin levels in a time-dependent manner following a glucose load in mice.

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Epac mediates PACAP-dependent long-term depression in the hippocampus.

http://www.wikidata.org/entity/Q33383710

description

2008 nî lūn-bûn

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2008 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած

@hyw

2008 թվականի նոյեմբերին հրատարակված գիտական հոդված

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2008年の論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年论文

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name

Epac mediates PACAP-dependent long-term depression in the hippocampus.

@ast

Epac mediates PACAP-dependent long-term depression in the hippocampus.

@en

type

label

Epac mediates PACAP-dependent long-term depression in the hippocampus.

@ast

Epac mediates PACAP-dependent long-term depression in the hippocampus.

@en

prefLabel

Epac mediates PACAP-dependent long-term depression in the hippocampus.

@ast

Epac mediates PACAP-dependent long-term depression in the hippocampus.

@en

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JPHYSIOL.2008.157461

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The Journal of Physiology

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Epac mediates PACAP-dependent long-term depression in the hippocampus.

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Federica Bertaso

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Frédéric de Bock

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Hervé Daniel

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Jeanne Ster

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Karine Abitbol

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Laurent Fagni

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P2860

Epac is a Rap1 guanine-nucleotide-exchange factor directly activated by cyclic AMP

A family of cAMP-binding proteins that directly activate Rap1

Mechanism of regulation of the Epac family of cAMP-dependent RapGEFs

Long-lasting potentiation of synaptic transmission in the dentate area of the anaesthetized rabbit following stimulation of the perforant path

Homosynaptic long-term depression in area CA1 of hippocampus and effects of N-methyl-D-aspartate receptor blockade

Hippocampal long-term depression and depotentiation are defective in mice carrying a targeted disruption of the gene encoding the RI beta subunit of cAMP-dependent protein kinase

Exchange protein activated by cAMP (Epac) mediates cAMP activation of p38 MAPK and modulation of Ca2+-dependent K+ channels in cerebellar neurons

Epac-selective cAMP analog 8-pCPT-2'-O-Me-cAMP as a stimulus for Ca2+-induced Ca2+ release and exocytosis in pancreatic beta-cells.

Phosphorylation of the AMPA receptor subunit GluR2 differentially regulates its interaction with PDZ domain-containing proteins

Molecular pharmacology and structure of VPAC Receptors for VIP and PACAP

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