Identification of a potent natural triterpenoid inhibitor of proteosome chymotrypsin-like activity and NF-kappaB with antimyeloma activity in vitro and in vivo.
about
The 26S proteasome is a multifaceted target for anti-cancer therapiesIdentification of known drugs that act as inhibitors of NF-kappaB signaling and their mechanism of actionPristimerin causes G1 arrest, induces apoptosis, and enhances the chemosensitivity to gemcitabine in pancreatic cancer cellsPristimerin induces apoptosis in imatinib-resistant chronic myelogenous leukemia cells harboring T315I mutation by blocking NF-kappaB signaling and depleting Bcr-Abl.The triterpenoid pristimerin induces U87 glioma cell apoptosis through reactive oxygen species-mediated mitochondrial dysfunctionTherapeutic effects of lentivirus-mediated shRNA targeting of cyclin D1 in human gastric cancer.Targeting inflammatory pathways by triterpenoids for prevention and treatment of cancer.Pharmacological targets in the ubiquitin system offer new ways of treating cancer, neurodegenerative disorders and infectious diseases.Staphylococcus aureus Inhibits IL-8 Responses Induced by Pseudomonas aeruginosa in Airway Epithelial Cells.The ubiquitin-proteasomal system is critical for multiple myeloma: implications in drug discoveryTargeting tumor proteasome with traditional Chinese medicine.Targeting apoptosis pathway with natural terpenoids: implications for treatment of breast and prostate cancer.A review of connectivity map and computational approaches in pharmacogenomics.Pristimerin overcomes adriamycin resistance in breast cancer cells through suppressing Akt signaling.Proteasome inhibitors: an expanding army attacking a unique target.Network pharmacology applications to map the unexplored target space and therapeutic potential of natural products.Advances in identification and validation of protein targets of natural products without chemical modification.Blockade of NFκB activity by Sunitinib increases cell death in Bortezomib-treated endometrial carcinoma cells.Identification of molecular vulnerabilities in human multiple myeloma cells by RNA interference lethality screening of the druggable genomePristimerin attenuates ovalbumin-induced allergic airway inflammation in mice.Plant polyphenols as inhibitors of NF-κB induced cytokine production-a potential anti-inflammatory treatment for Alzheimer's disease?Telomerase Inhibitors from Natural Products and Their Anticancer Potential.
P2860
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P2860
Identification of a potent natural triterpenoid inhibitor of proteosome chymotrypsin-like activity and NF-kappaB with antimyeloma activity in vitro and in vivo.
description
2008 nî lūn-bûn
@nan
2008 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
Identification of a potent nat ...... activity in vitro and in vivo.
@ast
Identification of a potent nat ...... activity in vitro and in vivo.
@en
type
label
Identification of a potent nat ...... activity in vitro and in vivo.
@ast
Identification of a potent nat ...... activity in vitro and in vivo.
@en
prefLabel
Identification of a potent nat ...... activity in vitro and in vivo.
@ast
Identification of a potent nat ...... activity in vitro and in vivo.
@en
P2093
P2860
P1433
P1476
Identification of a potent nat ...... activity in vitro and in vivo.
@en
P2093
A Keith Stewart
Chang-Xin Shi
Jessica Schmidt
Jonathan J Keats
Stephen E Palmer
Xinliang Mao
Yuan Xiao Zhu
P2860
P304
P356
10.1182/BLOOD-2008-09-179796
P407
P577
2008-12-18T00:00:00Z