Lysine-specific demethylase 1 restricts hematopoietic progenitor proliferation and is essential for terminal differentiation. - Wikidata - awgldk - TriplyDB

Lysine-specific demethylase 1 restricts hematopoietic progenitor proliferation and is essential for terminal differentiation.

Lysine-specific demethylase 1 restricts hematopoietic progenitor proliferation and is essential for terminal differentiation.

http://www.wikidata.org/entity/Q33401808

about

Targeting histone methylation for cancer therapy: enzymes, inhibitors, biological activity and perspectives Therapeutic opportunities in Ewing sarcoma: EWS-FLI inhibition via LSD1 targeting Epigenetic regulators as promising therapeutic targets in acute myeloid leukemia Growth factor independence 1b (gfi1b) is important for the maturation of erythroid cells and the regulation of embryonic globin expression KDM1 class flavin-dependent protein lysine demethylases Hepatocyte Nuclear Factor 1A Is a Cell-Intrinsic Transcription Factor Required for B Cell Differentiation and Development in Mice Histone lysine-specific demethylase 1 (LSD1) protein is involved in Sal-like protein 4 (SALL4)-mediated transcriptional repression in hematopoietic stem cells SIRT1 and LSD1 competitively regulate KU70 functions in DNA repair and mutation acquisition in cancer cells Antagonistic actions of Rcor proteins regulate LSD1 activity and cellular differentiation Lysine-specific demethylase 1 is a therapeutic target for fetal hemoglobin induction Sin3a-associated Hdac1 and Hdac2 are essential for hematopoietic stem cell homeostasis and contribute differentially to hematopoiesis.Metabolic regulation of stem cell function.LSD1: biologic roles and therapeutic targeting.Histone demethylase LSD1-mediated repression of GATA-2 is critical for erythroid differentiation LSD1/KDM1A promotes hematopoietic commitment of hemangioblasts through downregulation of Etv2.Involvement of Toso in activation of monocytes, macrophages, and granulocytes Corepressor-dependent silencing of fetal hemoglobin expression by BCL11A.Histone demethylase Lsd1 represses hematopoietic stem and progenitor cell signatures during blood cell maturation.Epigenetics in cancer stem cells.RNAi screen identifies Jarid1b as a major regulator of mouse HSC activity.The role of chromatin modifiers in normal and malignant hematopoiesis The roles of Jumonji-type oxygenases in human disease.Epigenetic and genetic mechanisms in red cell biology.Reversible inhibitors of LSD1 as therapeutic agents in acute myeloid leukemia: clinical significance and progress to date.KDM1 histone lysine demethylases as targets for treatments of oncological and neurodegenerative disease.Pharmacological inhibition of LSD1 for the treatment of MLL-rearranged leukemia.Inhibitors of LSD1 as a potential therapy for acute myeloid leukemia.Lysine-specific histone demethylases in normal and malignant hematopoiesis.Reversible LSD1 inhibition interferes with global EWS/ETS transcriptional activity and impedes Ewing sarcoma tumor growth.Fetal hemoglobin regulation in β-thalassemia: heterogeneity, modifiers and therapeutic approaches.The KDM1A histone demethylase is a promising new target for the epigenetic therapy of medulloblastoma.Kit transduced signals counteract erythroid maturation by MAPK-dependent modulation of erythropoietin signaling and apoptosis induction in mouse fetal liver.Transcriptional Control of Stem and Progenitor Potential LSD1 is Required for Hair Cell Regeneration in Zebrafish.The LSD1 inhibitor RN-1 recapitulates the fetal pattern of hemoglobin synthesis in baboons (P. anubis).Concomitant epigenetic targeting of LSD1 and HDAC synergistically induces mitochondrial apoptosis in rhabdomyosarcoma cells.The lasting influence of LSD1 in the blood.The spleen microenvironment influences disease transformation in a mouse model of KITD816V-dependent myeloproliferative neoplasm.GATA2 regulates GATA1 expression through LSD1-mediated histone modification.Antitumor activity of LSD1 inhibitors in lung cancer.

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Lysine-specific demethylase 1 restricts hematopoietic progenitor proliferation and is essential for terminal differentiation.

http://www.wikidata.org/entity/Q33401808

description

2012 nî lūn-bûn

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2012 թուականի Յունիսին հրատարակուած գիտական յօդուած

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2012 թվականի հունիսին հրատարակված գիտական հոդված

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2012年の論文

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Lysine-specific demethylase 1 ...... for terminal differentiation.

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F Speleman

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10.1038/LEU.2012.157

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9

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26

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