Inhibition of oxygen sensors as a therapeutic strategy for ischaemic and inflammatory disease.
about
Hypoxia-based strategies for angiogenic induction: the dawn of a new era for ischemia therapy and tissue regenerationProlyl 4-hydroxylaseHypoxia-Inducible Histone Lysine Demethylases: Impact on the Aging Process and Age-Related DiseasesOxygen: Implications for Wound HealingNeutrophils and inflammatory resolution in the mucosaHIF hydroxylase pathways in cardiovascular physiology and medicinePhysiology and pharmacology of erythropoietinAttenuating myocardial ischemia by targeting A2B adenosine receptorsHIF1A reduces acute lung injury by optimizing carbohydrate metabolism in the alveolar epitheliumMolecular mechanisms of ischemic preconditioning in the kidneyMolecular mechanisms of action and therapeutic uses of pharmacological inhibitors of HIF-prolyl 4-hydroxylases for treatment of ischemic diseasesInhibition of 2-oxoglutarate dependent oxygenasesHypoxia--implications for pharmaceutical developmentsMechanism of hypoxia-inducible factor 1 alpha-mediated Mcl1 regulation in Helicobacter pylori-infected human gastric epithelium.In vivo evidence for long-term vascular remodeling resulting from chronic cerebral hypoperfusion in mice.Overexpression of KAI1 Protein in Diabetic Skin Tissues.Impaired Ca(2+)-handling in HIF-1alpha(+/-) mice as a consequence of pressure overload.In vivo modulation of hypoxia-inducible signaling by topographical helix mimetics.RNA-binding proteins implicated in the hypoxic response.Hearts of hypoxia-inducible factor prolyl 4-hydroxylase-2 hypomorphic mice show protection against acute ischemia-reperfusion injuryTargeting the A2B adenosine receptor during gastrointestinal ischemia and inflammationProlyl hydroxylation by EglN2 destabilizes FOXO3a by blocking its interaction with the USP9x deubiquitinase.Inhibition of hypoxia-inducible factor-targeting prolyl hydroxylase domain-containing protein 2 (PHD2) enhances matrix synthesis by human chondrocytes.Boosting the hypoxia-induced adaptive response in inflammatory bowel disease: a novel concept of treatment.Low-level laser therapy alleviates neuropathic pain and promotes function recovery in rats with chronic constriction injury: possible involvements in hypoxia-inducible factor 1α (HIF-1α).Differential sensitivity of hypoxia inducible factor hydroxylation sites to hypoxia and hydroxylase inhibitorsHIF-1 mediates pathogenic inflammatory responses to intestinal ischemia-reperfusion injury.Reporter ligand NMR screening method for 2-oxoglutarate oxygenase inhibitors.Deficiency of a transmembrane prolyl 4-hydroxylase in the zebrafish leads to basement membrane defects and compromised kidney functionThe prolyl hydroxylase inhibitor dimethyloxalylglycine enhances dentin sialophoshoprotein expression through VEGF-induced Runx2 stabilization2-Oxoglutarate-dependent dioxygenases are sensors of energy metabolism, oxygen availability, and iron homeostasis: potential role in the regulation of aging process.Genome-wide identification and annotation of HIF-1α binding sites in two cell lines using massively parallel sequencing.Targeting hypoxia signalling for the treatment of ischaemic and inflammatory diseasesLoss of PHD3 allows tumours to overcome hypoxic growth inhibition and sustain proliferation through EGFR.Wound healing improvement with PHD-2 silenced fibroblasts in diabetic mice.Nutrient-sensitized screening for drugs that shift energy metabolism from mitochondrial respiration to glycolysis.HIF transcription factors, inflammation, and immunity.Disruption of hypoxia-inducible transcription factor-prolyl hydroxylase domain-1 (PHD-1-/-) attenuates ex vivo myocardial ischemia/reperfusion injury through hypoxia-inducible factor-1α transcription factor and its target genes in mice.Reduced retinal neovascularization, vascular permeability, and apoptosis in ischemic retinopathy in the absence of prolyl hydroxylase-1 due to the prevention of hyperoxia-induced vascular obliteration.Oxygen-sensing PHDs regulate bone homeostasis through the modulation of osteoprotegerin.
P2860
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P2860
Inhibition of oxygen sensors as a therapeutic strategy for ischaemic and inflammatory disease.
description
2009 nî lūn-bûn
@nan
2009 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
Inhibition of oxygen sensors a ...... emic and inflammatory disease.
@ast
Inhibition of oxygen sensors a ...... emic and inflammatory disease.
@en
type
label
Inhibition of oxygen sensors a ...... emic and inflammatory disease.
@ast
Inhibition of oxygen sensors a ...... emic and inflammatory disease.
@en
prefLabel
Inhibition of oxygen sensors a ...... emic and inflammatory disease.
@ast
Inhibition of oxygen sensors a ...... emic and inflammatory disease.
@en
P356
P1476
Inhibition of oxygen sensors a ...... emic and inflammatory disease.
@en
P2093
Julián Aragonés
Peter Fraisl
P2888
P304
P356
10.1038/NRD2761
P577
2009-01-23T00:00:00Z