Targeted correction of RUNX1 mutation in FPD patient-specific induced pluripotent stem cells rescues megakaryopoietic defects. - Wikidata - awgldk - TriplyDB

Targeted correction of RUNX1 mutation in FPD patient-specific induced pluripotent stem cells rescues megakaryopoietic defects.

Targeted correction of RUNX1 mutation in FPD patient-specific induced pluripotent stem cells rescues megakaryopoietic defects.

http://www.wikidata.org/entity/Q33416990

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Concise Review: Induced Pluripotent Stem Cells as New Model Systems in Oncology Modeling Human Bone Marrow Failure Syndromes Using Pluripotent Stem Cells and Genome Engineering Level of RUNX1 activity is critical for leukemic predisposition but not for thrombocytopenia.Hematopoietic transcription factor mutations and inherited platelet dysfunction.Thrombocytopenia in MDS: epidemiology, mechanisms, clinical consequences and novel therapeutic strategies.Inherited platelet dysfunction and hematopoietic transcription factor mutations.Dysregulation of PLDN (pallidin) is a mechanism for platelet dense granule deficiency in RUNX1 haplodeficiency.Hematopoietic transcription factor mutations: important players in inherited platelet defects.Bone marrow pathologic abnormalities in familial platelet disorder with propensity for myeloid malignancy and germline RUNX1 mutation.The Use of Patient-Specific Induced Pluripotent Stem Cells (iPSCs) to Identify Osteoclast Defects in Rare Genetic Bone Disorders Preleukemia: one name, many meanings.Gene correction in patient-specific iPSCs for therapy development and disease modeling.iPSCs and fibroblast subclones from the same fibroblast population contain comparable levels of sequence variations.Ten years of iPSC: clinical potential and advances in vitro hematopoietic differentiation.Role of RUNX1 in hematological malignancies.Myeloid neoplasms with germ line RUNX1 mutation.Ex vivo Generation of Genetically Modified Macrophages from Human Induced Pluripotent Stem Cells.Clinical utility gene card for: Familial platelet disorder with associated myeloid malignancies Human NOTCH4 is a key target of RUNX1 in megakaryocytic differentiation.Induced Pluripotent Stem Cell-Derived Megakaryocytes and Platelets for Disease Modeling and Future Clinical Applications.NOTCHing down a win for megakaryocytes.RUNX1 and CBFβ Mutations and Activities of Their Wild-Type Alleles in AML.How I diagnose and manage individuals at risk for inherited myeloid malignancies.Modeling Hematological Diseases and Cancer With Patient-Specific Induced Pluripotent Stem Cells

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Targeted correction of RUNX1 mutation in FPD patient-specific induced pluripotent stem cells rescues megakaryopoietic defects.

http://www.wikidata.org/entity/Q33416990

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2014 nî lūn-bûn

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2014 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած

@hyw

2014 թվականի սեպտեմբերին հրատարակված գիտական հոդված

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2014年の論文

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2014年論文

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2014年論文

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2014年論文

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2014年論文

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2014年論文

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2014年论文

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name

Targeted correction of RUNX1 m ...... cues megakaryopoietic defects.

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Targeted correction of RUNX1 m ...... cues megakaryopoietic defects.

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Targeted correction of RUNX1 m ...... cues megakaryopoietic defects.

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Targeted correction of RUNX1 m ...... cues megakaryopoietic defects.

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Targeted correction of RUNX1 m ...... cues megakaryopoietic defects.

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Targeted correction of RUNX1 m ...... cues megakaryopoietic defects.

@en

P2093

Abdel G Elkahloun

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Erika M Kwon

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Jon P Connelly

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Niraj S Trivedi

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P Paul Liu

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Yongxing Gao

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P2860

Disruption of the Cbfa2 gene causes necrosis and hemorrhaging in the central nervous system and blocks definitive hematopoiesis

Familial mutations of the transcription factor RUNX1 (AML1, CBFA2) predispose to acute myeloid leukemia

AML1, the target of multiple chromosomal translocations in human leukemia, is essential for normal fetal liver hematopoiesis

The haemangioblast generates haematopoietic cells through a haemogenic endothelium stage

A more efficient method to generate integration-free human iPS cells

Haploinsufficiency of CBFA2 causes familial thrombocytopenia with propensity to develop acute myelogenous leukaemia.

In vitro analyses of known and novel RUNX1/AML1 mutations in dominant familial platelet disorder with predisposition to acute myelogenous leukemia: implications for mechanisms of pathogenesis.

Association of CBFA2 mutation with decreased platelet PKC-theta and impaired receptor-mediated activation of GPIIb-IIIa and pleckstrin phosphorylation: proteins regulated by CBFA2 play a role in GPIIb-IIIa activation.

Low Mpl receptor expression in a pedigree with familial platelet disorder with predisposition to acute myelogenous leukemia and a novel AML1 mutation.

Megakaryocyte development and platelet production.

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1926-1930

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scholarly article

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10.1182/BLOOD-2014-01-550525

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12

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124

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Marshall Horwitz

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2014-09-01T00:00:00Z

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264711984

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25114263

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