RASA3 is a critical inhibitor of RAP1-dependent platelet activation - Wikidata - awgldk - TriplyDB

RASA3 is a critical inhibitor of RAP1-dependent platelet activation

RASA3 is a critical inhibitor of RAP1-dependent platelet activation

http://www.wikidata.org/entity/Q33420627

about

Platelet signaling: a complex interplay between inhibitory and activatory networks The Phosphatidylinositol 3,4,5-trisphosphate (PI(3,4,5)P3) Binder Rasa3 Regulates Phosphoinositide 3-kinase (PI3K)-dependent Integrin αIIbβ3 Outside-in Signaling.Evaluation of the immature platelet fraction contribute to the differential diagnosis of hereditary, immune and other acquired thrombocytopenias.Fibrin activates GPVI in human and mouse platelets Novel mutations in RASGRP2, which encodes CalDAG-GEFI, abrogate Rap1 activation, causing platelet dysfunction.RAP1-GTPase signaling and platelet function.Platelet immunoreceptor tyrosine-based activation motif (ITAM) and hemITAM signaling and vascular integrity in inflammation and development.Identification of loci associated with susceptibility to subspecies () tissue infection in cattle.New Concepts and Mechanisms of Platelet Activation Signaling.Mice Expressing Low Levels of CalDAG-GEFI Exhibit Markedly Impaired Platelet Activation With Minor Impact on Hemostasis.Platelet signaling--blood's great balancing act.The small molecule MERTK inhibitor UNC2025 decreases platelet activation and prevents thrombosis.Structure, Pharmacology and Roles in Physiology of the P2Y12 Receptor.Rasa3 controls turnover of endothelial cell adhesion and vascular lumen integrity by a Rap1-dependent mechanism.Negative regulators of platelet activation and adhesion.Calcium-induced structural rearrangements release autoinhibition in the Rap-GEF, CalDAG-GEFI.

P2860

Q26765384-47EB0148-AC9B-4A0E-B37F-241271E5E998 Q33437252-8E445F46-5A2D-48C3-8852-F9481E4E9C88 Q33442686-1F40A9D5-1261-45BD-B4F2-2C39434BEDE2 Q36091308-B5EE96BE-F792-44C9-990E-1B13E41518BF Q37228334-EF9BF3EA-106D-4F4A-939B-6DC6407B650B Q38596028-EDC3C008-CA52-4EBA-AFCD-D43895EDAC9C Q38691519-419525DD-7AEC-4B54-9EEA-F6958E9A128B Q38852302-1B28B1C3-DE80-4AC2-B4F3-F7D0790CD27B Q39147112-25AC094D-A02E-473E-99DB-EB0D573F2044 Q40958997-665CEC28-3D3E-461E-9816-265659F5C3FB Q43164268-784C6447-DDB1-42EF-AEFB-F3879BBF1615 Q45873319-47137C9B-00FF-4B79-9BDA-9305A3FAF6C5 Q47786748-FFA76749-B798-469C-9570-AFAB05912CC7 Q48141856-7CA8D3D9-AD00-43E8-B141-D67C61B55000 Q49377778-4F7692F3-60F0-4B9C-98AD-52C10AF60DF0 Q52603836-43BB760D-1857-4FA2-9DE9-6507B6C5F981

P2860

RASA3 is a critical inhibitor of RAP1-dependent platelet activation

http://www.wikidata.org/entity/Q33420627

description

2015 nî lūn-bûn

@nan

2015 թուականի Փետրուարին հրատարակուած գիտական յօդուած

@hyw

2015 թվականի փետրվարին հրատարակված գիտական հոդված

@hy

2015年の論文

@ja

2015年論文

@yue

2015年論文

@zh-hant

2015年論文

@zh-hk

2015年論文

@zh-mo

2015年論文

@zh-tw

2015年论文

@wuu

name

RASA3 is a critical inhibitor of RAP1-dependent platelet activation

@ast

RASA3 is a critical inhibitor of RAP1-dependent platelet activation

@en

type

label

RASA3 is a critical inhibitor of RAP1-dependent platelet activation

@ast

RASA3 is a critical inhibitor of RAP1-dependent platelet activation

@en

prefLabel

RASA3 is a critical inhibitor of RAP1-dependent platelet activation

@ast

RASA3 is a critical inhibitor of RAP1-dependent platelet activation

@en

P1433

Q33420627-23AF2B6A-F78E-4189-B8AA-72297B5E25EA

P1476

Q33420627-CF0B3E3A-DEAD-4927-AF0F-1443ABA1F45F

P2093

Q33420627-0C1DB112-D41C-447C-A6FB-61E13F2D3796

Q33420627-0DD7740A-280A-4553-A275-37F786CB94DB

Q33420627-44FD37E6-D32E-4F00-A6A2-C3F3B18A6FA9

Q33420627-663149F5-7CBD-439A-93FE-A89490594D89

Q33420627-69A8ED9E-6E81-48C8-8EAC-A2855E110643

Q33420627-8BC0BE03-6462-4A6A-8907-559B94B75AFD

Q33420627-A66C5900-FE16-4F23-8B7C-09FB3362BA5B

Q33420627-B5B24FED-53FA-4A59-8033-034FCFA0C0BD

Q33420627-BB45F0F0-0CAA-4D90-8F14-1F431B06CB9D

Q33420627-D9F0282B-B13E-4E8A-B67B-F58AF8ECBE2A

P2860

Q33420627-0082862A-E2BE-496F-BC6B-9B2A3AC202EC

Q33420627-058025F2-8277-4034-9955-8A70945A0457

Q33420627-0A1A3A5B-5796-428D-A527-CCE9989514CF

Q33420627-145883C9-FB20-46C2-8B27-A716E4C76091

Q33420627-1BE620DE-7C7F-44FA-829A-082E1528BF38

Q33420627-1BFE9288-0BBA-4046-B125-4C441165E42E

Q33420627-1D864DC4-CFE0-47A2-970D-CF3508A23800

Q33420627-1DFEE742-ADA6-4F65-9AC8-9B8DDE8365A4

Q33420627-20DE02C3-F57E-42EB-9FDB-CB11D3A9C9F9

Q33420627-22FB1331-EBD2-48E0-B068-2DF5BD5BA351

P304

Q33420627-5B90705C-2375-4374-9BDE-F56756A84851

P31

Q33420627-C6660760-FBD9-4615-9FAD-B98C5EDE3F1E

P356

Q33420627-405EABBF-4DFC-4204-ACC7-F14B67F8BC38

P407

Q33420627-00478729-9205-46F9-98E7-436C1F83DC5B

P433

Q33420627-D1A311FF-2E81-4455-B5C4-7DAA00139BAE

P478

Q33420627-6824E6F8-6998-413D-98D8-04C37885FC91

P50

Q33420627-204EB078-2B6C-41AF-B2FC-F7B4404AD581

Q33420627-27ADA10F-7AC6-4B85-9BA0-BCB95A7EAD9C

Q33420627-2913E6F2-DD4A-4734-A6D7-A08AAF65D7ED

Q33420627-BA9880AC-5415-4CD4-8158-371D13453F09

Q33420627-E3136139-16FD-4FF9-940A-F419E9EC6720

P577

Q33420627-F5E14F33-F706-455E-BE01-5025BD3D341D

P5875

Q33420627-C5FE8C3F-CE9F-4AB5-A650-AC6210037B4C

P698

Q33420627-394B750B-4656-48E8-AC7B-2B90D223B322

P932

Q33420627-4F9FD036-4F30-4EFF-A0C8-C38E9C7A0004

P356

P1433

Journal of Clinical Investigation

P1476

RASA3 is a critical inhibitor of RAP1-dependent platelet activation

@en

P2093

David S Paul

http://www.w3.org/2001/XMLSchema#string

E Ricky Chan

http://www.w3.org/2001/XMLSchema#string

Kathleen M Caron

http://www.w3.org/2001/XMLSchema#string

Luanne L Peters

http://www.w3.org/2001/XMLSchema#string

Mark D Adams

http://www.w3.org/2001/XMLSchema#string

Matthew C Parrott

http://www.w3.org/2001/XMLSchema#string

Nigel Mackman

http://www.w3.org/2001/XMLSchema#string

Raymond F Robledo

http://www.w3.org/2001/XMLSchema#string

Raymond Piatt

http://www.w3.org/2001/XMLSchema#string

Robert A Campbell

http://www.w3.org/2001/XMLSchema#string

P2860

Distinct localization and function of (1,4,5)IP(3) receptor subtypes and the (1,3,4,5)IP(4) receptor GAP1(IP4BP) in highly purified human platelet membranes

Human CalDAG-GEFI gene (RASGRP2) mutation affects platelet function and causes severe bleeding

Structural analysis of autoinhibition in the Ras-specific exchange factor RasGRP1

Ras activation in platelets after stimulation of the thrombin receptor, thromboxane A2 receptor or protein kinase C

Identification of a specific Ins(1,3,4,5)P4-binding protein as a member of the GAP1 family

Phosphorylation-induced conformational changes in Rap1b: allosteric effects on switch domains and effector loop

An EF hand mutation in Stim1 causes premature platelet activation and bleeding in mice

CalDAG-GEFI integrates signaling for platelet aggregation and thrombus formation

Evidence that pre-existent variability in platelet response to ADP accounts for 'clopidogrel resistance'

Proteasome function is required for platelet production

P304

1419-1432

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1172/JCI77993

http://www.w3.org/2001/XMLSchema#string

P407

P433

4

http://www.w3.org/2001/XMLSchema#string

P478

125

http://www.w3.org/2001/XMLSchema#string

P50

Lucia Stefanini

YACINE BOULAFTALI

Caterina Casari

Daniel O Kechele

P577

2015-02-23T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

272749517

http://www.w3.org/2001/XMLSchema#string

P698

25705885

http://www.w3.org/2001/XMLSchema#string

P932

4396462

http://www.w3.org/2001/XMLSchema#string