In vivo, in vitro and in silico methods for small molecule transfer across the BBB.
about
Phosphodiesterases as therapeutic targets for Alzheimer's disease.Gd(3+) complexes conjugated to Pittsburgh compound B: potential MRI markers of β-amyloid plaques.Associating a negatively charged GdDOTA-derivative to the Pittsburgh compound B for targeting Aβ amyloid aggregates.Towards Better BBB Passage Prediction Using an Extensive and Curated Data Set.Brainpeps: the blood-brain barrier peptide database.Characterization of a novel brain barrier ex vivo insect-based P-glycoprotein screening model.In vivo assessment of the permeability of the blood-brain barrier and blood-retinal barrier to fluorescent indoline derivatives in zebrafish.Simvastatin Hydroxy Acid Fails to Attain Sufficient Central Nervous System Tumor Exposure to Achieve a Cytotoxic Effect: Results of a Preclinical Cerebral Microdialysis Study.Structure-based ligand discovery for the Large-neutral Amino Acid Transporter 1, LAT-1Efflux transporters in the blood-brain interfaces--in vitro and in vivo methods and correlations.Assaying embryotoxicity in the test tube: current limitations of the embryonic stem cell test (EST) challenging its applicability domain.Improving the prediction of drug disposition in the brain.In silico prediction of brain exposure: drug free fraction, unbound brain to plasma concentration ratio and equilibrium half-life.Nano-enabled delivery systems across the blood-brain barrier.Blood-brain barrier shuttle peptides: an emerging paradigm for brain delivery.Design of brain imaging agents for positron emission tomography: do large bioconjugates provide an opportunity for in vivo brain imaging?Methotrexate-loaded chitosan- and glycol chitosan-based nanoparticles: a promising strategy for the administration of the anticancer drug to brain tumors.PiB-Conjugated, Metal-Based Imaging Probes: Multimodal Approaches for the Visualization of β-Amyloid Plaques.Pharmacokinetic investigation of sildenafil using positron emission tomography and determination of its effect on cerebrospinal fluid cGMP levels.A method to predict different mechanisms for blood-brain barrier permeability of CNS activity compounds in Chinese herbs using support vector machine.In vitro prediction of human intestinal absorption and blood-brain barrier partitioning: development of a lipid analog for micellar liquid chromatography.Predicting drug penetration across the blood-brain barrier: comparison of micellar liquid chromatography and immobilized artificial membrane liquid chromatography.Cannabinoid 1 G protein-coupled receptor (periphero-)neutral antagonists: emerging therapeutics for treating obesity-driven metabolic disease and reducing cardiovascular risk.Evaluation of sphingomyelin, cholester, and phosphatidylcholine-based immobilized artificial membrane liquid chromatography to predict drug penetration across the blood-brain barrier.Gallium-68 Complexes Conjugated to Pittsburgh Compound B: Radiolabeling and Biological Evaluation.Impact of Neurodegenerative Diseases on Drug Binding to Brain Tissues: From Animal Models to Human Samples.In Vivo and In Vitro Characteristics of Radiolabeled Vesamicol Analogs as the Vesicular Acetylcholine Transporter Imaging Agents.In Silico ADME/Tox PredictionsDevelopment of an (S)-1-{2-[Tris(4-methoxyphenyl)methoxy]ethyl}piperidine-3-carboxylic acid [(S)-SNAP-5114] Carba Analogue Inhibitor for Murine γ-Aminobutyric Acid Transporter Type 4
P2860
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P2860
In vivo, in vitro and in silico methods for small molecule transfer across the BBB.
description
2009 nî lūn-bûn
@nan
2009 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
In vivo, in vitro and in silico methods for small molecule transfer across the BBB.
@ast
In vivo, in vitro and in silico methods for small molecule transfer across the BBB.
@en
type
label
In vivo, in vitro and in silico methods for small molecule transfer across the BBB.
@ast
In vivo, in vitro and in silico methods for small molecule transfer across the BBB.
@en
prefLabel
In vivo, in vitro and in silico methods for small molecule transfer across the BBB.
@ast
In vivo, in vitro and in silico methods for small molecule transfer across the BBB.
@en
P356
P1476
In vivo, in vitro and in silico methods for small molecule transfer across the BBB.
@en
P2093
Claire Mackie
Jurgen Mensch
P304
P356
10.1002/JPS.21745
P407
P577
2009-12-01T00:00:00Z