The drusenlike phenotype in aging Ccl2-knockout mice is caused by an accelerated accumulation of swollen autofluorescent subretinal macrophages. - Wikidata - awgldk - TriplyDB

The drusenlike phenotype in aging Ccl2-knockout mice is caused by an accelerated accumulation of swollen autofluorescent subretinal macrophages.

The drusenlike phenotype in aging Ccl2-knockout mice is caused by an accelerated accumulation of swollen autofluorescent subretinal macrophages.

http://www.wikidata.org/entity/Q33478316

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Inflammation and its role in age-related macular degeneration Animal models of age related macular degeneration Differential modulation of retinal degeneration by Ccl2 and Cx3cr1 chemokine signalling Retinal vasculature of adult zebrafish: in vivo imaging using confocal scanning laser ophthalmoscopy.Characterisation of a C1qtnf5 Ser163Arg knock-in mouse model of late-onset retinal macular degeneration Zinc deficiency leads to lipofuscin accumulation in the retinal pigment epithelium of pigmented rats Suppression of experimental choroidal neovascularization by curcumin in mice Von Hippel-Lindau protein in the RPE is essential for normal ocular growth and vascular development Blockade of VEGFR1 and 2 suppresses pathological angiogenesis and vascular leakage in the eye Defective photoreceptor phagocytosis in a mouse model of enhanced S-cone syndrome causes progressive retinal degeneration.Age-related alterations in the dynamic behavior of microglia.The severity of retinal pathology in homozygous Crb1rd8/rd8 mice is dependent on additional genetic factors.In vivo multi-modal imaging of experimental autoimmune uveoretinitis in transgenic reporter mice reveals the dynamic nature of inflammatory changes during disease progression.Protective effects of human iPS-derived retinal pigment epithelium cell transplantation in the retinal dystrophic rat Abundant lipid and protein components of drusen Microglia-derived IL-1β promotes chemokine expression by Müller cells and RPE in focal retinal degeneration.Viewing ageing eyes: diverse sites of amyloid Beta accumulation in the ageing mouse retina and the up-regulation of macrophages.Cigarette smoke-related hydroquinone dysregulates MCP-1, VEGF and PEDF expression in retinal pigment epithelium in vitro and in vivo.Relationship between complement membrane attack complex, chemokine (C-C motif) ligand 2 (CCL2) and vascular endothelial growth factor in mouse model of laser-induced choroidal neovascularization.Deficiency of CC chemokine ligand 2 and decay-accelerating factor causes retinal degeneration in mice Dysregulation in retinal para-inflammation and age-related retinal degeneration in CCL2 or CCR2 deficient mice.Optimization of in vivo confocal autofluorescence imaging of the ocular fundus in mice and its application to models of human retinal degeneration.Suppression and regression of choroidal neovascularization in mice by a novel CCR2 antagonist, INCB3344 Studying age-related macular degeneration using animal models.γδ T cells as a major source of IL-17 production during age-dependent RPE degeneration.Single nucleotide polymorphisms in MCP-1 and its receptor are associated with the risk of age related macular degeneration.Ccl2, Cx3cr1 and Ccl2/Cx3cr1 chemokine deficiencies are not sufficient to cause age-related retinal degeneration.JNK inhibition reduces apoptosis and neovascularization in a murine model of age-related macular degeneration.Age- and light-dependent development of localised retinal atrophy in CCL2(-/-)CX3CR1(GFP/GFP) mice.CX3CL1/CX3CR1 and CCL2/CCR2 chemokine/chemokine receptor complex in patients with AMD.Retinal pigment epithelium defects accelerate photoreceptor degeneration in cell type-specific knockout mouse models of choroideremia A CTRP5 gene S163R mutation knock-in mouse model for late-onset retinal degeneration Early focal expression of the chemokine Ccl2 by Müller cells during exposure to damage-inducing bright continuous light Toll-like receptor 3 is required for development of retinopathy caused by impaired all-trans-retinal clearance in mice.Exosomes from retinal astrocytes contain antiangiogenic components that inhibit laser-induced choroidal neovascularization.The role of macrophage class a scavenger receptors in a laser-induced murine choroidal neovascularization model.VEGF receptor blockade markedly reduces retinal microglia/macrophage infiltration into laser-induced CNV.Differences in the distribution, phenotype and gene expression of subretinal microglia/macrophages in C57BL/6N (Crb1 rd8/rd8) versus C57BL6/J (Crb1 wt/wt) mice.Chemokine-mediated inflammation in the degenerating retina is coordinated by Müller cells, activated microglia, and retinal pigment epithelium RAGE regulates immune cell infiltration and angiogenesis in choroidal neovascularization.

P2860

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P2860

The drusenlike phenotype in aging Ccl2-knockout mice is caused by an accelerated accumulation of swollen autofluorescent subretinal macrophages.

http://www.wikidata.org/entity/Q33478316

description

2009 nî lūn-bûn

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2009 թուականի Յուլիսին հրատարակուած գիտական յօդուած

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2009 թվականի հուլիսին հրատարակված գիտական հոդված

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2009年の論文

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2009年論文

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2009年論文

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2009年論文

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2009年論文

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2009年論文

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2009年论文

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The drusenlike phenotype in ag ...... escent subretinal macrophages.

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The drusenlike phenotype in ag ...... escent subretinal macrophages.

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Investigative Ophthalmology & Visual Science

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Frederick W Fitzke

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Peter M G Munro

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Robin R Ali

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Susie E Barker

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Ulrich F O Luhmann

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Vy Luong

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Yanai Duran

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P2860

An animal model of age-related macular degeneration in senescent Ccl-2- or Ccr-2-deficient mice

An integrated hypothesis that considers drusen as biomarkers of immune-mediated processes at the RPE-Bruch's membrane interface in aging and age-related macular degeneration

Impaired monocyte migration and reduced type 1 (Th1) cytokine responses in C-C chemokine receptor 2 knockout mice

Severe reduction in leukocyte adhesion and monocyte extravasation in mice deficient in CC chemokine receptor 2.

In vivo confocal imaging of the retina in animal models using scanning laser ophthalmoscopy.

EIAV vector-mediated delivery of endostatin or angiostatin inhibits angiogenesis and vascular hyperpermeability in experimental CNV.

CX3CR1-dependent subretinal microglia cell accumulation is associated with cardinal features of age-related macular degeneration.

Complement factor H deficiency in aged mice causes retinal abnormalities and visual dysfunction.

Age-dependent accumulation of lipofuscin in perivascular and subretinal microglia in experimental mice.

Comprehensive analysis of the candidate genes CCL2, CCR2, and TLR4 in age-related macular degeneration

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5934-5943

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10.1167/IOVS.09-3462

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12

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Robert E. MacLaren

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26647944

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2801148

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