Lyn, PKC-delta, SHIP-1 interactions regulate GPVI-mediated platelet-dense granule secretion - Wikidata - awgldk - TriplyDB

Lyn, PKC-delta, SHIP-1 interactions regulate GPVI-mediated platelet-dense granule secretion

Lyn, PKC-delta, SHIP-1 interactions regulate GPVI-mediated platelet-dense granule secretion

http://www.wikidata.org/entity/Q33479912

about

Protein kinase C δ deficiency enhances megakaryopoiesis and recovery from thrombocytopenia.Reactive oxygen species play a critical role in collagen-induced platelet activation via SHP-2 oxidation.Inhibiting tyrosine phosphorylation of protein kinase Cδ (PKCδ) protects the salivary gland from radiation damage CGX1037 is a novel PKC isoform delta selective inhibitor in platelets.CD2AP/SHIP1 complex positively regulates plasmacytoid dendritic cell receptor signaling by inhibiting the E3 ubiquitin ligase Cbl Distinct and overlapping functional roles of Src family kinases in mouse platelets.The BCR-ABL inhibitor ponatinib inhibits platelet immunoreceptor tyrosine-based activation motif (ITAM) signaling, platelet activation and aggregate formation under shear.Peroxiredoxin II is an antioxidant enzyme that negatively regulates collagen-stimulated platelet function Overexpression of the autoimmunity-associated phosphatase PTPN22 promotes survival of antigen-stimulated CLL cells by selectively activating AKT.Novel phosphatidylethanolamine derivatives accumulate in circulation in hyperlipidemic ApoE-/- mice and activate platelets via TLR2.Tyrosine phosphorylation on spleen tyrosine kinase (Syk) is differentially regulated in human and murine platelets by protein kinase C isoforms.Diverse functions of protein kinase C isoforms in platelet activation and thrombus formation.Inhibitor and activator: dual functions for SHIP in immunity and cancer.New prospects for drug development: the hedgehog pathway revealed. Focus on hematologic malignancies.Src family kinases: at the forefront of platelet activation PKC-epsilon deficiency alters progenitor cell populations in favor of megakaryopoiesis.Activation/Inhibition of mast cells by supra-optimal antigen concentrations Regulation of platelet activation and thrombus formation by reactive oxygen species Pharmacological targeting of phosphoinositide lipid kinases and phosphatases in the immune system: success, disappointment, and new opportunities.Platelet activation in hypertension associated with hypercholesterolemia: effects of irbesartan.Signalling in Neutrophils: A Retro Look

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P2860

Lyn, PKC-delta, SHIP-1 interactions regulate GPVI-mediated platelet-dense granule secretion

http://www.wikidata.org/entity/Q33479912

description

2009 nî lūn-bûn

@nan

2009 թուականի Յուլիսին հրատարակուած գիտական յօդուած

@hyw

2009 թվականի հուլիսին հրատարակված գիտական հոդված

@hy

2009年の論文

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2009年論文

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2009年論文

@zh-hant

2009年論文

@zh-hk

2009年論文

@zh-mo

2009年論文

@zh-tw

2009年论文

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name

Lyn, PKC-delta, SHIP-1 interac ...... atelet-dense granule secretion

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Lyn, PKC-delta, SHIP-1 interac ...... atelet-dense granule secretion

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type

label

Lyn, PKC-delta, SHIP-1 interac ...... atelet-dense granule secretion

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Lyn, PKC-delta, SHIP-1 interac ...... atelet-dense granule secretion

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prefLabel

Lyn, PKC-delta, SHIP-1 interac ...... atelet-dense granule secretion

@ast

Lyn, PKC-delta, SHIP-1 interac ...... atelet-dense granule secretion

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Lyn, PKC-delta, SHIP-1 interac ...... atelet-dense granule secretion

@en

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Archana Sanjay

http://www.w3.org/2001/XMLSchema#string

James L Daniel

http://www.w3.org/2001/XMLSchema#string

Ramya Chari

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Satya P Kunapuli

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Soochong Kim

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Swaminathan Murugappan

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P2860

Physical and functional interaction between protein kinase C delta and Fyn tyrosine kinase in human platelets

Protein kinase C-delta is a negative regulator of antigen-induced mast cell degranulation

The 145-kDa protein induced to associate with Shc by multiple cytokines is an inositol tetraphosphate and phosphatidylinositol 3,4,5-triphosphate 5-phosphatase

Sustained activation of Lyn tyrosine kinase in vivo leads to autoimmunity

Fyn and Lyn phosphorylate the Fc receptor gamma chain downstream of glycoprotein VI in murine platelets, and Lyn regulates a novel feedback pathway

Signalling through phosphoinositide 3-kinases: the lipids take centre stage

The inositol 5'-phosphatase SHIP-1 and the Src kinase Lyn negatively regulate macrophage colony-stimulating factor-induced Akt activity

Tyrosine phosphorylation and relocation of SHIP are integrin-mediated in thrombin-stimulated human blood platelets

GPVI and integrin alphaIIb beta3 signaling in platelets

Cloning and characterization of human SHIP, the 145-kD inositol 5-phosphatase that associates with SHC after cytokine stimulation

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2756209

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