Design and NMR-based screening of LEF, a library of chemical fragments with different local environment of fluorine.
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Applications of (19)F-NMR in Fragment-Based Drug Discovery5-Fluoroimidazo[4,5-b]pyridine Is a Privileged Fragment That Conveys Bioavailability to Potent Trypanosomal Methionyl-tRNA Synthetase InhibitorsConformational Plasticity in Glycomimetics: Fluorocarbamethyl-L-idopyranosides Mimic the Intrinsic Dynamic Behaviour of Natural Idose Rings.Weak Intermolecular Hydrogen Bonds with Fluorine: Detection and Implications for Enzymatic/Chemical Reactions, Chemical Properties, and Ligand/Protein Fluorine NMR Screening.Comprehensive survey of chemical libraries for drug discovery and chemical biology: 2009.Rapid acquisition of 1H and 19F NMR experiments for direct and competition ligand-based screening.Development of fragment-based n-FABS NMR screening applied to the membrane enzyme FAAH.Design and generation of highly diverse fluorinated fragment libraries and their efficient screening with improved (19) F NMR methodology.Halogen-enriched fragment libraries as chemical probes for harnessing halogen bonding in fragment-based lead discovery.SEAL by NMR: glyco-based selenium-labeled affinity ligands detected by NMR spectroscopy.Affinity screening using competitive binding with fluorine-19 hyperpolarized ligandsNMRmix: A Tool for the Optimization of Compound Mixtures in 1D (1)H NMR Ligand Affinity Screens.Rational Design of Orthogonal Multipolar Interactions with Fluorine in Protein-Ligand ComplexesDemystifying fluorine chemical shifts: electronic structure calculations address origins of seemingly anomalous (19)F-NMR spectra of fluorohistidine isomers and analogues.Fluorinated carbohydrates as lectin ligands: dissecting glycan-cyanovirin interactions by using 19F NMR spectroscopy.Computational medicinal chemistry in fragment-based drug discovery: what, how and when.Chemogenomics in drug discovery: computational methods based on the comparison of binding sites.Molecular characterization of the boron adducts of the proteasome inhibitor bortezomib with epigallocatechin-3-gallate and related polyphenols.Single Diastereomer of a Macrolactam Core Binds Specifically to Myeloid Cell Leukemia 1 (MCL1)Synthesis of fluorinated maltose derivatives for monitoring protein interaction by (19)F NMR.Parallelized Ligand Screening Using Dissolution Dynamic Nuclear Polarization.Evaluating electronic structure methods for accurate calculation of 19 F chemical shifts in fluorinated amino acids.Current NMR Techniques for Structure-Based Drug Discovery.A Ligand-Based NMR Screening Approach for the Identification and Characterization of Inhibitors and Promoters of Amyloid Peptide Aggregation.19 F NMR isotropic chemical shift for efficient screening of fluorinated fragments which are racemates and/or display multiple conformers.Achievement of 1 H-19 F heteronuclear experiments using the conventional spectrometer with a shared single high band amplifier.Multinuclear nanoliter one-dimensional and two-dimensional NMR spectroscopy with a single non-resonant microcoil.Making sure there's a "give" associated with the "take": producing and using open-source software in big pharma.Investigation of RNA-Ligand Interactions by 19F NMR Spectroscopy Using Fluorinated Probes
P2860
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P2860
Design and NMR-based screening of LEF, a library of chemical fragments with different local environment of fluorine.
description
2009 nî lūn-bûn
@nan
2009 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
Design and NMR-based screening ...... local environment of fluorine.
@ast
Design and NMR-based screening ...... local environment of fluorine.
@en
type
label
Design and NMR-based screening ...... local environment of fluorine.
@ast
Design and NMR-based screening ...... local environment of fluorine.
@en
prefLabel
Design and NMR-based screening ...... local environment of fluorine.
@ast
Design and NMR-based screening ...... local environment of fluorine.
@en
P2093
P356
P1476
Design and NMR-based screening ...... local environment of fluorine.
@en
P2093
Claudio Dalvit
Richard Lewis
Ulrich Hommel
P304
12949-12959
P356
10.1021/JA905207T
P407
P577
2009-09-01T00:00:00Z