Discovery and validation of a series of aryl sulfonamides as selective inhibitors of tissue-nonspecific alkaline phosphatase (TNAP). - Wikidata - awgldk - TriplyDB

Discovery and validation of a series of aryl sulfonamides as selective inhibitors of tissue-nonspecific alkaline phosphatase (TNAP).

Discovery and validation of a series of aryl sulfonamides as selective inhibitors of tissue-nonspecific alkaline phosphatase (TNAP).

http://www.wikidata.org/entity/Q33509850

about

Kinetic analysis of substrate utilization by native and TNAP-, NPP1-, or PHOSPHO1-deficient matrix vesicles Alkaline phosphatase: a novel treatment target for cardiovascular disease in CKD.Human alkaline phosphatase dephosphorylates microbial products and is elevated in preterm neonates with a history of late-onset sepsis Assay format as a critical success factor for identification of novel inhibitor chemotypes of tissue-nonspecific alkaline phosphatase from high-throughput screening High-throughput screening of tissue-nonspecific alkaline phosphatase for identification of effectors with diverse modes of action The role of inorganic pyrophosphate in aortic valve calcification.Design, synthesis and evaluation of benzoisothiazolones as selective inhibitors of PHOSPHO1.Inhibition of hippocampal synaptic activity by ATP, hypoxia or oxygen-glucose deprivation does not require CD73.Direct determination of phosphatase activity from physiological substrates in cells.Extracellular pyrophosphate metabolism and calcification in vascular smooth muscle.Pathophysiological role of vascular smooth muscle alkaline phosphatase in medial artery calcification.Intestinal alkaline phosphatase to treat necrotizing enterocolitis.Pharmacological inhibition of PHOSPHO1 suppresses vascular smooth muscle cell calcification.Tissue-nonspecific alkaline phosphatase acts redundantly with PAP and NT5E to generate adenosine in the dorsal spinal cord.Soluble ecto-5'-nucleotidase (5'-NT), alkaline phosphatase, and adenosine deaminase (ADA1) activities in neonatal blood favor elevated extracellular adenosine.Therapeutic potentials of ecto-nucleoside triphosphate diphosphohydrolase, ecto-nucleotide pyrophosphatase/phosphodiesterase, ecto-5'-nucleotidase, and alkaline phosphatase inhibitors.Regulating the Rate of Molecular Self-Assembly for Targeting Cancer Cells.Ectopic calcification in pseudoxanthoma elasticum responds to inhibition of tissue-nonspecific alkaline phosphatase.Self-Assembling Ability Determines the Activity of Enzyme-Instructed Self-Assembly for Inhibiting Cancer Cells.Tricyclic coumarin sulphonate derivatives with alkaline phosphatase inhibitory effects: in vitro and docking studies.Enzymatic Self-Assembly Confers Exceptionally Strong Synergism with NF-κB Targeting for Selective Necroptosis of Cancer Cells.Discovery of 5-((5-chloro-2-methoxyphenyl)sulfonamido)nicotinamide (SBI-425), a potent and orally bioavailable tissue-nonspecific alkaline phosphatase (TNAP) inhibitor.Alkaline Phosphatase Inhibitors Attenuate Renovascular Responses to Norepinephrine.CD73-TNAP crosstalk regulates the hypertrophic response and cardiomyocyte calcification due to α1 adrenoceptor activation.Active Probes for Imaging Membrane Dynamics of Live Cells with High Spatial and Temporal Resolution over Extended Time Scales and Areas.

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P2860

Discovery and validation of a series of aryl sulfonamides as selective inhibitors of tissue-nonspecific alkaline phosphatase (TNAP).

http://www.wikidata.org/entity/Q33509850

description

2009 nî lūn-bûn

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2009 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած

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2009 թվականի նոյեմբերին հրատարակված գիտական հոդված

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2009年の論文

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2009年学术文章

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2009年学术文章

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2009年学术文章

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2009年学术文章

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2009年学术文章

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2009年學術文章

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Discovery and validation of a ...... c alkaline phosphatase (TNAP).

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Discovery and validation of a ...... c alkaline phosphatase (TNAP).

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Discovery and validation of a ...... c alkaline phosphatase (TNAP).

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Discovery and validation of a ...... c alkaline phosphatase (TNAP).

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Discovery and validation of a ...... c alkaline phosphatase (TNAP).

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Discovery and validation of a ...... c alkaline phosphatase (TNAP).

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Journal of Medicinal Chemistry

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Discovery and validation of a ...... c alkaline phosphatase (TNAP).

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P2093

Ana Maria Simao

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Arianna Mangravita-Novo

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Brock Brown

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Eduard A Sergienko

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José Luis Millán

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Li Yang

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Michael Vicchiarelli

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Nicholas D P Cosford

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Russell Dahl

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Sonoko Narisawa

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P2860

Inorganic pyrophosphate generation and disposition in pathophysiology

Upregulation of alkaline phosphatase and pyrophosphate hydrolysis: potential mechanism for uremic vascular calcification

Functional involvement of PHOSPHO1 in matrix vesicle-mediated skeletal mineralization.

Novel inhibitors of alkaline phosphatase suppress vascular smooth muscle cell calcification.

Identification and characterization of novel tissue-nonspecific alkaline phosphatase inhibitors with diverse modes of action

Tissue-nonspecific alkaline phosphatase and plasma cell membrane glycoprotein-1 are central antagonistic regulators of bone mineralization

Concerted regulation of inorganic pyrophosphate and osteopontin by akp2, enpp1, and ank: an integrated model of the pathogenesis of mineralization disorders.

Pyrophosphate inhibits mineralization of osteoblast cultures by binding to mineral, up-regulating osteopontin, and inhibiting alkaline phosphatase activity.

Design and synthesis of pyrazole derivatives as potent and selective inhibitors of tissue-nonspecific alkaline phosphatase (TNAP).

Unique coexpression in osteoblasts of broadly expressed genes accounts for the spatial restriction of ECM mineralization to bone.

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10.1021/JM900383S

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