A BCR-ABL mutant lacking direct binding sites for the GRB2, CBL and CRKL adapter proteins fails to induce leukemia in mice

A BCR-ABL mutant lacking direct binding sites for the GRB2, CBL and CRKL adapter proteins fails to induce leukemia in mice

Item
http://www.wikidata.org/entity/Q33510153
The proximal signaling network of the BCR-ABL1 oncogene shows a modular organizationC3G forms complexes with Bcr-Abl and p38α MAPK at the focal adhesions in chronic myeloid leukemia cells: implication in the regulation of leukemic cell adhesion.Phosphorylation of Crk on tyrosine 251 in the RT loop of the SH3C domain promotes Abl kinase transactivationDownregulation of miR-31, miR-155, and miR-564 in chronic myeloid leukemia cellsBCR-ABL1 promotes leukemia by converting p27 into a cytoplasmic oncoprotein.Emerging roles for crk in human cancer.Combination of bortezomib and mitotic inhibitors down-modulate Bcr-Abl and efficiently eliminates tyrosine-kinase inhibitor sensitive and resistant Bcr-Abl-positive leukemic cells.Potentiation of Nilotinib-mediated cell death in the context of the bone marrow microenvironment requires a promiscuous JAK inhibitor in CML.The chimeric ubiquitin ligase SH2-U-box inhibits the growth of imatinib-sensitive and resistant CML by targeting the native and T315I-mutant BCR-ABLConcise review: cancer cells escape from oncogene addiction: understanding the mechanisms behind treatment failure for more effective targeting.The role of CT10 regulation of kinase-like in cancer.Cholesterol esterification inhibition and imatinib treatment synergistically inhibit growth of BCR-ABL mutation-independent resistant chronic myelogenous leukemiaTargeting BCR-ABL+ stem/progenitor cells and BCR-ABL-T315I mutant cells by effective inhibition of the BCR-ABL-Tyr177-GRB2 complex.Antibody arrays identify protein-protein interactions in chronic myeloid leukaemia.
P2860

A BCR-ABL mutant lacking direct binding sites for the GRB2, CBL and CRKL adapter proteins fails to induce leukemia in mice

Item
http://www.wikidata.org/entity/Q33510153
description
2009 nî lūn-bûn
@nan
2009 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
A BCR-ABL mutant lacking direc ...... ils to induce leukemia in mice
@ast
A BCR-ABL mutant lacking direc ...... ils to induce leukemia in mice
@en
type
label
A BCR-ABL mutant lacking direc ...... ils to induce leukemia in mice
@ast
A BCR-ABL mutant lacking direc ...... ils to induce leukemia in mice
@en
prefLabel
A BCR-ABL mutant lacking direc ...... ils to induce leukemia in mice
@ast
A BCR-ABL mutant lacking direc ...... ils to induce leukemia in mice
@en
P1433
P1476
P2093
P2860
P304
P31
P356
P407
P433
P478
P50
P577
P5875
P698
P932
P356
P1433
P1476
A BCR-ABL mutant lacking direc ...... ils to induce leukemia in mice
@en
P2093
P2860
P304
P31
P356
10.1371/JOURNAL.PONE.0007439
P407
P433
P478
P50
P577
P5875
P698
P932