The Akt/PKB family of protein kinases: a review of small molecule inhibitors and progress towards target validation: a 2009 update.
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P90 RSK arranges Chk1 in the nucleus for monitoring of genomic integrity during cell proliferationRoles of Akt and SGK1 in the Regulation of Renal Tubular TransportDrugs for allosteric sites on receptorsCrystal Structure of Human AKT1 with an Allosteric Inhibitor Reveals a New Mode of Kinase InhibitionB Cell Receptor Activation Predominantly Regulates AKT-mTORC1/2 Substrates Functionally Related to RNA ProcessingComputational identification of significant missense mutations in AKT1 gene.Development of sulfonamide AKT PH domain inhibitors.PI 3-kinase-dependent phosphorylation of Plk1-Ser99 promotes association with 14-3-3γ and is required for metaphase-anaphase transition.Spirotetronate polyketides as leads in drug discovery.Phenylalanine-Based Inactivator of AKT Kinase: Design, Synthesis, and Biological Evaluation.Inhibition of Akt with small molecules and biologics: historical perspective and current status of the patent landscape.Pathophysiological roles of Pim-3 kinase in pancreatic cancer development and progression.Prediction of off-target effects on angiotensin-converting enzyme 2.IKBKE protein activates Akt independent of phosphatidylinositol 3-kinase/PDK1/mTORC2 and the pleckstrin homology domain to sustain malignant transformationAkt: a double-edged sword in cell proliferation and genome stability.2013 Philip S. Portoghese Medicinal Chemistry Lectureship: drug discovery targeting allosteric sites.Differences in molecular genetics between pediatric and adult malignant astrocytomas: age matters.Activation of Akt at T308 and S473 in alcohol, tobacco and HPV-induced HNSCC: is there evidence to support a prognostic or diagnostic role?The Akt-specific inhibitor MK2206 selectively inhibits thyroid cancer cells harboring mutations that can activate the PI3K/Akt pathway.Alpha-lipoic acid activates eNOS through activation of PI3-kinase/Akt signaling pathwayMechanistic analysis of a DNA damage-induced, PTEN-dependent size checkpoint in human cellsOpposing functions of Akt isoforms in lung tumor initiation and progressionSyk activation of phosphatidylinositol 3-kinase/Akt prevents HtrA2-dependent loss of X-linked inhibitor of apoptosis protein (XIAP) to promote survival of Epstein-Barr virus+ (EBV+) B cell lymphomas.Akt isoform-specific signaling in breast cancer: uncovering an anti-migratory role for palladin.Targeting the phosphatidylinositol 3-kinase signaling pathway in breast cancer.The effect Akt2 deletion on tumor development in Pten(+/-) mice.Targeting the mTOR-DEPTOR pathway by CRL E3 ubiquitin ligases: therapeutic applicationIdentification of allosteric binding sites for PI3Kα oncogenic mutant specific inhibitor design.Safety and tolerability of AZD5363 in Japanese patients with advanced solid tumorsSPLINTS: small-molecule protein ligand interface stabilizers.Spirohexenolide A targets human macrophage migration inhibitory factor (hMIF)Roles of Pim-3, a novel survival kinase, in tumorigenesis.Advances in understanding the pathogenesis of systemic anaplastic large cell lymphomas.Ghrelin's Effects on Proinflammatory Cytokine Mediated Apoptosis and Their Impact on β-Cell Functionality.Bioactive compound reveals a novel function for ribosomal protein S5 in hepatic stellate cell activation and hepatic fibrosis.PDK1 controls upstream PI3K expression and PIP3 generation.A novel PKB/Akt inhibitor, MK-2206, effectively inhibits insulin-stimulated glucose metabolism and protein synthesis in isolated rat skeletal muscle.Latanoprost promotes neurite outgrowth in differentiated RGC-5 cells via the PI3K-Akt-mTOR signaling pathway.Akt inhibitors reduce glucose uptake independently of their effects on Akt.Changes of PI3K/AKT/BCL2 signaling proteins in congenital Giant Nevi: melanocytes contribute to their increased survival and integrity.
P2860
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P2860
The Akt/PKB family of protein kinases: a review of small molecule inhibitors and progress towards target validation: a 2009 update.
description
2010 nî lūn-bûn
@nan
2010 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
The Akt/PKB family of protein ...... get validation: a 2009 update.
@ast
The Akt/PKB family of protein ...... get validation: a 2009 update.
@en
The Akt/PKB family of protein ...... get validation: a 2009 update.
@nl
type
label
The Akt/PKB family of protein ...... get validation: a 2009 update.
@ast
The Akt/PKB family of protein ...... get validation: a 2009 update.
@en
The Akt/PKB family of protein ...... get validation: a 2009 update.
@nl
prefLabel
The Akt/PKB family of protein ...... get validation: a 2009 update.
@ast
The Akt/PKB family of protein ...... get validation: a 2009 update.
@en
The Akt/PKB family of protein ...... get validation: a 2009 update.
@nl
P1476
The Akt/PKB family of protein ...... get validation: a 2009 update.
@en
P304
P356
10.2174/156802610790980602
P577
2010-01-01T00:00:00Z