Artemisinin directly targets malarial mitochondria through its specific mitochondrial activation.
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Artemisinin-resistant malaria: research challenges, opportunities, and public health implicationsExpression in Yeast Links Field Polymorphisms in PfATP6 to in Vitro Artemisinin Resistance and Identifies New Inhibitor ClassesArtemisinin-based antimalarial research: application of biotechnology to the production of artemisinin, its mode of action, and the mechanism of resistance of Plasmodium parasites3,6-Epidioxy-1,10-bisaboladiene inhibits G1 -specific transcription through Swi4/Swi6 and Mbp1/Swi6 via the Hog1 stress pathway in yeast.Artemisinin Action and Resistance in Plasmodium falciparumArtemisinin inhibits chloroplast electron transport activity: mode of actionEvidence for the contribution of the hemozoin synthesis pathway of the murine Plasmodium yoelii to the resistance to artemisinin-related drugsAntimalarial iron chelator, FBS0701, shows asexual and gametocyte Plasmodium falciparum activity and single oral dose cure in a murine malaria modelAnti-plasmodial polyvalent interactions in Artemisia annua L. aqueous extract--possible synergistic and resistance mechanismsCryo transmission X-ray imaging of the malaria parasite, P. falciparum.Untargeted Proteomics and Systems-Based Mechanistic Investigation of Artesunate in Human Bronchial Epithelial Cells.A barcode of organellar genome polymorphisms identifies the geographic origin of Plasmodium falciparum strains.Natural products: a continuing source of novel drug leadsArtemisone uptake in Plasmodium falciparum-infected erythrocytes.The plant-based immunomodulator curcumin as a potential candidate for the development of an adjunctive therapy for cerebral malariaAntimalarial action of artesunate involves DNA damage mediated by reactive oxygen speciesArtemisinins, new miconazole potentiators resulting in increased activity against Candida albicans biofilms.Artesunate tolerance in transgenic Plasmodium falciparum parasites overexpressing a tryptophan-rich protein.In vitro anti-plasmodial activity of Dicoma anomala subsp. gerrardii (Asteraceae): identification of its main active constituent, structure-activity relationship studies and gene expression profilingPhenotypic and genotypic analysis of in vitro-selected artemisinin-resistant progeny of Plasmodium falciparumEfficacy of artemether-lumefantrine in treatment of malaria among under-fives and prevalence of drug resistance markers in Igombe-Mwanza, north-western Tanzania.Lack of association of the S769N mutation in Plasmodium falciparum SERCA (PfATP6) with resistance to artemisinins.Disruption of spermatogenesis in the liver fluke, Fasciola hepatica by two artemisinin derivatives, artemether and artesunate.A Drug Combination Screen Identifies Drugs Active against Amoxicillin-Induced Round Bodies of In Vitro Borrelia burgdorferi Persisters from an FDA Drug LibraryEffect of Farnesyltransferase Inhibitor R115777 on Mitochondria of Plasmodium falciparumPlasmodium parasites mount an arrest response to dihydroartemisinin, as revealed by whole transcriptome shotgun sequencing (RNA-seq) and microarray study.H2O2 dynamics in the malaria parasite Plasmodium falciparumMonoclonal Antibodies That Recognize the Alkylation Signature of Antimalarial Ozonides OZ277 (Arterolane) and OZ439 (Artefenomel).Haemoglobin degradation underpins the sensitivity of early ring stage Plasmodium falciparum to artemisinins1,4-naphthoquinones and other NADPH-dependent glutathione reductase-catalyzed redox cyclers as antimalarial agentsCurrent therapies and future possibilities for drug development against liver-stage malaria.Sesquiterpenoids lactones: benefits to plants and people.Organism-like formation of Schistosoma hemozoin and its function suggest a mechanism for anti-malarial action of artemisinin.Artemisinin analogue SM934 attenuate collagen-induced arthritis by suppressing T follicular helper cells and T helper 17 cells.The molecular and cellular action properties of artemisinins: what has yeast told us?Artemisinin derivative artesunate induces radiosensitivity in cervical cancer cells in vitro and in vivo.Qinghaosu (artemisinin): chemistry and pharmacology.A mitochondria-targeting artemisinin derivative with sharply increased antitumor but depressed anti-yeast and anti-malaria activities.Antimalarial drugs: modes of action and mechanisms of parasite resistance.The pharmacogenetics of antimalaria artemisinin combination therapy.
P2860
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P2860
Artemisinin directly targets malarial mitochondria through its specific mitochondrial activation.
description
2010 nî lūn-bûn
@nan
2010 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի մարտին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Artemisinin directly targets m ...... ific mitochondrial activation.
@ast
Artemisinin directly targets m ...... ific mitochondrial activation.
@en
Artemisinin directly targets m ...... ific mitochondrial activation.
@nl
type
label
Artemisinin directly targets m ...... ific mitochondrial activation.
@ast
Artemisinin directly targets m ...... ific mitochondrial activation.
@en
Artemisinin directly targets m ...... ific mitochondrial activation.
@nl
prefLabel
Artemisinin directly targets m ...... ific mitochondrial activation.
@ast
Artemisinin directly targets m ...... ific mitochondrial activation.
@en
Artemisinin directly targets m ...... ific mitochondrial activation.
@nl
P2093
P2860
P50
P921
P1433
P1476
Artemisinin directly targets m ...... ific mitochondrial activation.
@en
P2093
P2860
P356
10.1371/JOURNAL.PONE.0009582
P407
P577
2010-03-08T00:00:00Z