Lovastatin induces apoptosis of ovarian cancer cells and synergizes with doxorubicin: potential therapeutic relevance - Wikidata - awgldk - TriplyDB

Lovastatin induces apoptosis of ovarian cancer cells and synergizes with doxorubicin: potential therapeutic relevance

Lovastatin induces apoptosis of ovarian cancer cells and synergizes with doxorubicin: potential therapeutic relevance

http://www.wikidata.org/entity/Q33542856

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The hedgehog receptor patched is involved in cholesterol transport Discovery of 7-hydroxy-6-methoxy-2-methyl-3-(3,4,5-trimethoxybenzoyl)benzo[b]furan (BNC105), a tubulin polymerization inhibitor with potent antiproliferative and tumor vascular disrupting properties.Protein Lipidation As a Regulator of Apoptotic Calcium Release: Relevance to Cancer.NCI60 cancer cell line panel data and RNAi analysis help identify EAF2 as a modulator of simvastatin and lovastatin response in HCT-116 cells.Statin therapy is associated with improved survival in patients with non-serous-papillary epithelial ovarian cancer: a retrospective cohort analysis.Simvastatin potently induces calcium-dependent apoptosis of human leiomyoma cells.Hypermethylation of the TGF-β target, ABCA1 is associated with poor prognosis in ovarian cancer patients Mevalonate Pathway Antagonist Suppresses Formation of Serous Tubal Intraepithelial Carcinoma and Ovarian Carcinoma in Mouse Models.Inhibition of NF-κB Pathway and Modulation of MAPK Signaling Pathways in Glioblastoma and Implications for Lovastatin and Tumor Necrosis Factor-Related Apoptosis Inducing Ligand (TRAIL) Combination Therapy.Fluvastatin inhibits FLT3 glycosylation in human and murine cells and prolongs survival of mice with FLT3/ITD leukemia.In vitro and in vivo downregulation of the ATP binding cassette transporter B1 by the HMG-CoA reductase inhibitor simvastatin A Designed Inhibitor of p53 Aggregation Rescues p53 Tumor Suppression in Ovarian Carcinomas Simvastatin increases the antineoplastic actions of paclitaxel carried in lipid nanoemulsions in melanoma-bearing mice H3K4 methyltransferase Set1 is involved in maintenance of ergosterol homeostasis and resistance to Brefeldin A.Transcriptional profiling of breast cancer cells in response to mevinolin: Evidence of cell cycle arrest, DNA degradation and apoptosis.Aberrant lipid metabolism: an emerging diagnostic and therapeutic target in ovarian cancer.Ovarian tumour growth is characterized by mevalonate pathway gene signature in an orthotopic, syngeneic model of epithelial ovarian cancer.Targeting tumor cell metabolism with statins.Anticancer and antifungal compounds from Aspergillus, Penicillium and other filamentous fungi.HMG-CoA reductase inhibitors as adjuvant treatment for hematologic malignancies: what is the current evidence?Exploitation of pleiotropic actions of statins by using tumour-targeted delivery systems.Inhibition of the mevalonate pathway augments the activity of pitavastatin against ovarian cancer cells.Lovastatin enhances adenovirus-mediated TRAIL induced apoptosis by depleting cholesterol of lipid rafts and affecting CAR and death receptor expression of prostate cancer cells.The interplay between cell signalling and the mevalonate pathway in cancer.Suppressive effects of simvastatin on the human acute promyelocytic leukemia NB4 cell line through the regulation of the nuclear factor-κB signaling pathway.Gamma Tocopherol and Lovastatin Additively Induced Apoptosis in Human Colorectal Carcinoma Cell Line (HT29).Molecularly targeted therapies for p53-mutant cancers.Anti-cancer characteristics of mevinolin against three different solid tumor cell lines was not solely p53-dependent.CYR61 downregulation reduces osteosarcoma cell invasion, migration, and metastasis.Statin use and uterine fibroid risk in hyperlipidemia patients: a nested case-control study.Characterization of Lovastatin biosynthetic cluster proteins in Aspergillus terreus strain ATCC 20542 Pyruvate kinase M2 is a poor prognostic marker of and a therapeutic target in ovarian cancer Simvastatin potentiates doxorubicin activity against MCF-7 breast cancer cells.Statin use is associated with improved survival in ovarian cancer: A retrospective population-based study.Atorvastatin exhibits anti-tumorigenic and anti-metastatic effects in ovarian cancer in vitro.Combined spectroscopic and molecular docking approach to probing binding interactions between lovastatin and calf thymus DNA.Therapeutic Roles of Statins in Gynecology and Obstetrics: The Current Evidence.Cell cycle inhibition without disruption of neurogenesis is a strategy for treatment of aberrant cell cycle diseases: an update.

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Lovastatin induces apoptosis of ovarian cancer cells and synergizes with doxorubicin: potential therapeutic relevance

http://www.wikidata.org/entity/Q33542856

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2010 nî lūn-bûn

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2010 թուականի Մարտին հրատարակուած գիտական յօդուած

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Lovastatin induces apoptosis o ...... otential therapeutic relevance

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Lovastatin induces apoptosis o ...... otential therapeutic relevance

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Lovastatin induces apoptosis o ...... tential therapeutic relevance.

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Lovastatin induces apoptosis o ...... otential therapeutic relevance

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Lovastatin induces apoptosis o ...... otential therapeutic relevance

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Lovastatin induces apoptosis o ...... tential therapeutic relevance.

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Lovastatin induces apoptosis o ...... otential therapeutic relevance

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Lovastatin induces apoptosis o ...... otential therapeutic relevance

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Lovastatin induces apoptosis o ...... tential therapeutic relevance.

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Anna Martirosyan

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Carolyn A Goard

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P2860

Actions of a histone deacetylase inhibitor NSC3852 (5-nitroso-8-quinolinol) link reactive oxygen species to cell differentiation and apoptosis in MCF-7 human mammary tumor cells

Cancer statistics, 2008

HMG-CoA reductase inhibitors and P-glycoprotein modulation

Effect of pravastatin on survival in patients with advanced hepatocellular carcinoma. A randomized controlled trial

Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors

Regulation of the mevalonate pathway

A phase I-II trial of lovastatin for anaplastic astrocytoma and glioblastoma multiforme.

Differential sensitivity of various pediatric cancers and squamous cell carcinomas to lovastatin-induced apoptosis: therapeutic implications.

Fluvastatin reduces proliferation and increases apoptosis in women with high grade breast cancer.

Drug interactions with lipid-lowering drugs: mechanisms and clinical relevance.

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