A thiolase of Mycobacterium tuberculosis is required for virulence and production of androstenedione and androstadienedione from cholesterol. - Wikidata - awgldk - TriplyDB

A thiolase of Mycobacterium tuberculosis is required for virulence and production of androstenedione and androstadienedione from cholesterol.

A thiolase of Mycobacterium tuberculosis is required for virulence and production of androstenedione and androstadienedione from cholesterol.

http://www.wikidata.org/entity/Q33557918

about

High-resolution phenotypic profiling defines genes essential for mycobacterial growth and cholesterol catabolism Pathogen roid rage: cholesterol utilization by Mycobacterium tuberculosis Mycobacterium tuberculosis utilizes a unique heterotetrameric structure for dehydrogenation of the cholesterol side chain Mycobacterium tuberculosis CYP125A1, a steroid C27 monooxygenase that detoxifies intracellularly generated cholest-4-en-3-one A flavin-dependent monooxygenase from Mycobacterium tuberculosis involved in cholesterol catabolism Activity of 3-ketosteroid 9α-hydroxylase (KshAB) indicates cholesterol side chain and ring degradation occur simultaneously in Mycobacterium tuberculosis Mycobacterial cytochrome p450 125 (cyp125) catalyzes the terminal hydroxylation of c27 steroids Mycobacterium tuberculosis: success through dormancy Crystal Structure of a Monomeric Thiolase-Like Protein Type 1 (TLP1) from Mycobacterium smegmatis A highly conserved mycobacterial cholesterol catabolic pathway Substrate Specificities and Conformational Flexibility of 3-Ketosteroid 9α-Hydroxylases Mycobacterial genes essential for the pathogen's survival in the host Shrinking the FadE proteome of Mycobacterium tuberculosis: insights into cholesterol metabolism through identification of an α2β2 heterotetrameric acyl coenzyme A dehydrogenase family Cholesterol catabolism by Mycobacterium tuberculosis requires transcriptional and metabolic adaptations Functional redundancy of steroid C26-monooxygenase activity in Mycobacterium tuberculosis revealed by biochemical and genetic analyses Pathway profiling in Mycobacterium tuberculosis: elucidation of cholesterol-derived catabolite and enzymes that catalyze its metabolism Cholesterol utilization in mycobacteria is controlled by two TetR-type transcriptional regulators: kstR and kstR2 The Mycobacterium tuberculosis regulatory network and hypoxia Unraveling Cholesterol Catabolism in Mycobacterium tuberculosis: ChsE4-ChsE5 α2β2 Acyl-CoA Dehydrogenase Initiates β-Oxidation of 3-Oxo-cholest-4-en-26-oyl CoA.The Structure of the Transcriptional Repressor KstR in Complex with CoA Thioester Cholesterol Metabolites Sheds Light on the Regulation of Cholesterol Catabolism in Mycobacterium tuberculosis.Metabolic Perspectives on Persistence Catabolism and biotechnological applications of cholesterol degrading bacteria.Anoxic androgen degradation by the denitrifying bacterium Sterolibacterium denitrificans via the 2,3-seco pathway Improving the production of 22-hydroxy-23,24-bisnorchol-4-ene-3-one from sterols in Mycobacterium neoaurum by increasing cell permeability and modifying multiple genes Rv3723/LucA coordinates fatty acid and cholesterol uptake in Mycobacterium tuberculosis.Mycobacterium tuberculosis wears what it eats Microbial steroid transformations: current state and prospects.Statins increase rifampin mycobactericidal effect.A high-resolution network model for global gene regulation in Mycobacterium tuberculosis.The role of 3-ketosteroid 1(2)-dehydrogenase in the pathogenicity of Mycobacterium tuberculosis.Cholesterol is not an essential source of nutrition for Mycobacterium tuberculosis during infection Inhibition of the M. tuberculosis 3β-hydroxysteroid dehydrogenase by azasteroids.FadA5 a thiolase from Mycobacterium tuberculosis: a steroid-binding pocket reveals the potential for drug development against tuberculosis Cholesterol oxidase is indispensable in the pathogenesis of Mycobacterium tuberculosis Cholesterol catabolism as a therapeutic target in Mycobacterium tuberculosis.The tuberculosis drug discovery and development pipeline and emerging drug targets.Global analyses of TetR family transcriptional regulators in mycobacteria indicates conservation across species and diversity in regulated functions Metabolic modeling predicts metabolite changes in Mycobacterium tuberculosis.The Essential Role of Cholesterol Metabolism in the Intracellular Survival of Mycobacterium leprae Is Not Coupled to Central Carbon Metabolism and Energy Production.Detection of a Putative TetR-Like Gene Related to Mycobacterium bovis BCG Growth in Cholesterol Using a gfp-Transposon Mutagenesis System.

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P2860

A thiolase of Mycobacterium tuberculosis is required for virulence and production of androstenedione and androstadienedione from cholesterol.

http://www.wikidata.org/entity/Q33557918

description

2009 nî lūn-bûn

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2009 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած

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2009 թվականի հոտեմբերին հրատարակված գիտական հոդված

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2009年の論文

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2009年論文

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2009年論文

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2009年論文

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2009年論文

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2009年論文

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2009年论文

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name

A thiolase of Mycobacterium tu ...... tadienedione from cholesterol.

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A thiolase of Mycobacterium tu ...... tadienedione from cholesterol.

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A thiolase of Mycobacterium tu ...... tadienedione from cholesterol.

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type

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A thiolase of Mycobacterium tu ...... tadienedione from cholesterol.

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A thiolase of Mycobacterium tu ...... tadienedione from cholesterol.

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A thiolase of Mycobacterium tu ...... tadienedione from cholesterol.

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prefLabel

A thiolase of Mycobacterium tu ...... tadienedione from cholesterol.

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A thiolase of Mycobacterium tu ...... tadienedione from cholesterol.

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A thiolase of Mycobacterium tu ...... tadienedione from cholesterol.

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Infection and Immunity

P1476

A thiolase of Mycobacterium tu ...... tadienedione from cholesterol.

@en

P2093

Eugenie Dubnau

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Irina Kolesnikova

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Issar Smith

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Natasha M Nesbitt

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Patricia Fontán

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Xinxin Yang

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P2860

Studies of a ring-cleaving dioxygenase illuminate the role of cholesterol metabolism in the pathogenesis of Mycobacterium tuberculosis

The HHpred interactive server for protein homology detection and structure prediction

Intracellular cholesterol transport

Characterization of 3-ketosteroid 9{alpha}-hydroxylase, a Rieske oxygenase in the cholesterol degradation pathway of Mycobacterium tuberculosis

The Pfam protein families database

A RAPID METHOD OF TOTAL LIPID EXTRACTION AND PURIFICATION

Mechanistic studies on beta-ketoacyl thiolase from Zoogloea ramigera: identification of the active-site nucleophile as Cys89, its mutation to Ser89, and kinetic and thermodynamic characterization of wild-type and mutant enzymes

The thiolase superfamily: condensing enzymes with diverse reaction specificities

Cytological and transcript analyses reveal fat and lazy persister-like bacilli in tuberculous sputum

Rv1106c from Mycobacterium tuberculosis is a 3beta-hydroxysteroid dehydrogenase

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275-282

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scholarly article

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10.1128/IAI.00893-09

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1

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78

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2009-10-12T00:00:00Z

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19822655

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Mycobacterium tuberculosis

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2798224

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