A chimeric EGF-R-neu proto-oncogene allows EGF to regulate neu tyrosine kinase and cell transformation.
about
Oncogenic forms of the neu/HER2 tyrosine kinase are permanently coupled to phospholipase C gammaFGFR-4, a novel acidic fibroblast growth factor receptor with a distinct expression patternNeural expression and chromosomal mapping of Neu differentiation factor to 8p12-p21Identification of c-erbB-3 binding sites for phosphatidylinositol 3'-kinase and SHC using an EGF receptor/c-erbB-3 chimeraA hierarchical network of interreceptor interactions determines signal transduction by Neu differentiation factor/neuregulin and epidermal growth factorThe erbB-2 mitogenic signaling pathway: tyrosine phosphorylation of phospholipase C-gamma and GTPase-activating protein does not correlate with erbB-2 mitogenic potencyCell-type specific interaction of Neu differentiation factor (NDF/heregulin) with Neu/HER-2 suggests complex ligand-receptor relationshipsThe EGF receptor family--multiple roles in proliferation, differentiation, and neoplasia with an emphasis on HER4A specific combination of substrates is involved in signal transduction by the kit-encoded receptor.Expression of growth factor receptors in human brain tumours.c-erbB-2 protein overexpression in breast cancer is a risk factor in patients with involved and uninvolved lymph nodes.Two chimeric receptors of epidermal growth factor receptor and c-Ros that differ in their transmembrane domains have opposite effects on cell growth.Efficient coupling with phosphatidylinositol 3-kinase, but not phospholipase C gamma or GTPase-activating protein, distinguishes ErbB-3 signaling from that of other ErbB/EGFR family members.An epidermal growth factor receptor/ret chimera generates mitogenic and transforming signals: evidence for a ret-specific signaling pathway.eps15, a novel tyrosine kinase substrate, exhibits transforming activity.Biological and biochemical activities of a chimeric epidermal growth factor-Elk receptor tyrosine kinase.Morphogenetic effects of neuregulin (neu differentiation factor) in cultured epithelial cells.Early mutation of the neu (erbB-2) gene during ethylnitrosourea-induced oncogenesis in the rat Schwann cell lineage.Receptor functions and ligand-dependent transforming potential of a chimeric kit proto-oncogene.Mitogenic signals and transforming potential of Nyk, a newly identified neural cell adhesion molecule-related receptor tyrosine kinase.Down-regulation of cellular platelet-derived growth factor receptors induced by an activated neu receptor tyrosine kinase.Membrane-bound LERK2 ligand can signal through three different Eph-related receptor tyrosine kinases.The Xmrk receptor tyrosine kinase is activated in Xiphophorus malignant melanoma.Activation of the neu tyrosine kinase induces the fos/jun transcription factor complex, the glucose transporter and ornithine decarboxylase.Detection of the ligand activity of the c-erbB-2 protein in calf serum.
P2860
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P2860
A chimeric EGF-R-neu proto-oncogene allows EGF to regulate neu tyrosine kinase and cell transformation.
description
1989 nî lūn-bûn
@nan
1989 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
1989 թվականի հունվարին հրատարակված գիտական հոդված
@hy
1989年の論文
@ja
1989年論文
@yue
1989年論文
@zh-hant
1989年論文
@zh-hk
1989年論文
@zh-mo
1989年論文
@zh-tw
1989年论文
@wuu
name
A chimeric EGF-R-neu proto-onc ...... inase and cell transformation.
@ast
A chimeric EGF-R-neu proto-onc ...... inase and cell transformation.
@en
A chimeric EGF-R-neu proto-onc ...... inase and cell transformation.
@nl
type
label
A chimeric EGF-R-neu proto-onc ...... inase and cell transformation.
@ast
A chimeric EGF-R-neu proto-onc ...... inase and cell transformation.
@en
A chimeric EGF-R-neu proto-onc ...... inase and cell transformation.
@nl
prefLabel
A chimeric EGF-R-neu proto-onc ...... inase and cell transformation.
@ast
A chimeric EGF-R-neu proto-onc ...... inase and cell transformation.
@en
A chimeric EGF-R-neu proto-onc ...... inase and cell transformation.
@nl
P2093
P2860
P1433
P1476
A chimeric EGF-R-neu proto-onc ...... inase and cell transformation.
@en
P2093
Lehväslaiho H
Sistonen L
P2860
P304
P407
P577
1989-01-01T00:00:00Z