Metal-free ALS variants of dimeric human Cu,Zn-superoxide dismutase have enhanced populations of monomeric species
about
Redox regulation in amyotrophic lateral sclerosisIdentification of human monoclonal antibodies specific for human SOD1 recognizing distinct epitopes and forms of SOD1.Disulfide-reduced ALS variants of Cu, Zn superoxide dismutase exhibit increased populations of unfolded species.Superoxide dismutases and superoxide reductases.The H2A-H2B dimeric kinetic intermediate is stabilized by widespread hydrophobic burial with few fully native interactions.The Disulfide Bond, but Not Zinc or Dimerization, Controls Initiation and Seeded Growth in Amyotrophic Lateral Sclerosis-linked Cu,Zn Superoxide Dismutase (SOD1) Fibrillation.The small heat shock proteins αB-crystallin and Hsp27 suppress SOD1 aggregation in vitro.Glutathionylation potentiates benign superoxide dismutase 1 variants to the toxic forms associated with amyotrophic lateral sclerosis.Protein misfolding in the late-onset neurodegenerative diseases: common themes and the unique case of amyotrophic lateral sclerosis.An emerging role for misfolded wild-type SOD1 in sporadic ALS pathogenesis.Incorporation of a Reporter Peptide in FPOP Compensates for Adventitious Scavengers and Permits Time-Dependent Measurements.Destabilization of the dimer interface is a common consequence of diverse ALS-associated mutations in metal free SOD1Effect of Oxidative Damage on the Stability and Dimerization of Superoxide Dismutase 1.Susceptibility of Mutant SOD1 to Form a Destabilized Monomer Predicts Cellular Aggregation and Toxicity but Not In vitro Aggregation Propensity.Features of wild-type human SOD1 limit interactions with misfolded aggregates of mouse G86R Sod1.In-cell NMR reveals potential precursor of toxic species from SOD1 fALS mutants.Many roads lead to Rome? Multiple modes of Cu,Zn superoxide dismutase destabilization, misfolding and aggregation in amyotrophic lateral sclerosis.
P2860
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P2860
Metal-free ALS variants of dimeric human Cu,Zn-superoxide dismutase have enhanced populations of monomeric species
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2010 nî lūn-bûn
@nan
2010 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Metal-free ALS variants of dim ...... pulations of monomeric species
@ast
Metal-free ALS variants of dim ...... pulations of monomeric species
@en
Metal-free ALS variants of dim ...... ulations of monomeric species.
@nl
type
label
Metal-free ALS variants of dim ...... pulations of monomeric species
@ast
Metal-free ALS variants of dim ...... pulations of monomeric species
@en
Metal-free ALS variants of dim ...... ulations of monomeric species.
@nl
prefLabel
Metal-free ALS variants of dim ...... pulations of monomeric species
@ast
Metal-free ALS variants of dim ...... pulations of monomeric species
@en
Metal-free ALS variants of dim ...... ulations of monomeric species.
@nl
P2093
P2860
P1433
P1476
Metal-free ALS variants of dim ...... pulations of monomeric species
@en
P2093
Anna-Karin E Svensson
C Robert Matthews
Jessica A Adefusika
Jill A Zitzewitz
Osman Bilsel
P2860
P304
P356
10.1371/JOURNAL.PONE.0010064
P407
P577
2010-04-09T00:00:00Z