Broad specificity profiling of TALENs results in engineered nucleases with improved DNA-cleavage specificity - Wikidata - awgldk - TriplyDB

Broad specificity profiling of TALENs results in engineered nucleases with improved DNA-cleavage specificity

Broad specificity profiling of TALENs results in engineered nucleases with improved DNA-cleavage specificity

http://www.wikidata.org/entity/Q33566358

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Genome Engineering with TALE and CRISPR Systems in Neuroscience Minimizing off-Target Mutagenesis Risks Caused by Programmable Nucleases Single-Base Pair Genome Editing in Human Cells by Using Site-Specific Endonucleases Enabling functional genomics with genome engineering Designed nucleases for targeted genome editing Quantifying on- and off-target genome editing Transcription activator-like effector nuclease (TALEN)-mediated CLYBL targeting enables enhanced transgene expression and one-step generation of dual reporter human induced pluripotent stem cell (iPSC) and neural stem cell (NSC) lines.The epigenome: the next substrate for engineering Chromatin regulation at the frontier of synthetic biology Therapeutic genome editing: prospects and challenges Fusion of catalytically inactive Cas9 to FokI nuclease improves the specificity of genome modification Improving the DNA specificity and applicability of base editing through protein engineering and protein delivery.CHOPCHOP: a CRISPR/Cas9 and TALEN web tool for genome editing.Targeted gene correction minimally impacts whole-genome mutational load in human-disease-specific induced pluripotent stem cell clones.Engineering synthetic TALE and CRISPR/Cas9 transcription factors for regulating gene expression Optimized tuning of TALEN specificity using non-conventional RVDs.Multiplex CRISPR/Cas9-based genome editing for correction of dystrophin mutations that cause Duchenne muscular dystrophy.Choosing the Right Tool for the Job: RNAi, TALEN, or CRISPR.Direct observation of TALE protein dynamics reveals a two-state search mechanism A Multidrug-resistant Engineered CAR T Cell for Allogeneic Combination Immunotherapy.High-fidelity CRISPR-Cas9 nucleases with no detectable genome-wide off-target effects.Genome editing and the next generation of antiviral therapy.State-of-the-art human gene therapy: part II. Gene therapy strategies and clinical applications.Genome-wide detection of DNA double-stranded breaks induced by engineered nucleases.Functional genetics for all: engineered nucleases, CRISPR and the gene editing revolution Target specificity of the CRISPR-Cas9 system.Determining the specificities of TALENs, Cas9, and other genome-editing enzymes Genome editing strategies: potential tools for eradicating HIV-1/AIDS.Increased Specific Labeling of INS-1 Pancreatic Beta-Cell by Using RIP-Driven Cre Mutants with Reduced Activity Context influences on TALE-DNA binding revealed by quantitative profiling.Genome-wide specificity of DNA binding, gene regulation, and chromatin remodeling by TALE- and CRISPR/Cas9-based transcriptional activators Multi-reporter selection for the design of active and more specific zinc-finger nucleases for genome editing.TALEored Epigenetics: A DNA-Binding Scaffold for Programmable Epigenome Editing and Analysis.Targeted Disruption of the β2-Microglobulin Gene Minimizes the Immunogenicity of Human Embryonic Stem Cells Continuous directed evolution of DNA-binding proteins to improve TALEN specificity.STAR: a simple TAL effector assembly reaction using isothermal assembly.Current Overview of TALEN Construction Systems.CAUSEL: an epigenome- and genome-editing pipeline for establishing function of noncoding GWAS variants.Homology-driven genome editing in hematopoietic stem and progenitor cells using ZFN mRNA and AAV6 donors.Long-term multilineage engraftment of autologous genome-edited hematopoietic stem cells in nonhuman primates.

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P2860

Broad specificity profiling of TALENs results in engineered nucleases with improved DNA-cleavage specificity

http://www.wikidata.org/entity/Q33566358

description

2014 nî lūn-bûn

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2014 թուականի Փետրուարին հրատարակուած գիտական յօդուած

@hyw

2014 թվականի փետրվարին հրատարակված գիտական հոդված

@hy

2014年の論文

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2014年論文

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2014年論文

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2014年論文

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2014年論文

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2014年論文

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2014年论文

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name

Broad specificity profiling of ...... roved DNA-cleavage specificity

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Broad specificity profiling of ...... roved DNA-cleavage specificity

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Broad specificity profiling of ...... oved DNA-cleavage specificity.

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type

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Broad specificity profiling of ...... roved DNA-cleavage specificity

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Broad specificity profiling of ...... roved DNA-cleavage specificity

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Broad specificity profiling of ...... oved DNA-cleavage specificity.

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Broad specificity profiling of ...... roved DNA-cleavage specificity

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Broad specificity profiling of ...... roved DNA-cleavage specificity

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Broad specificity profiling of ...... oved DNA-cleavage specificity.

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Broad specificity profiling of ...... roved DNA-cleavage specificity

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P2093

David R Liu

http://www.w3.org/2001/XMLSchema#string

Deepak Reyon

http://www.w3.org/2001/XMLSchema#string

J Keith Joung

http://www.w3.org/2001/XMLSchema#string

Jeffry D Sander

http://www.w3.org/2001/XMLSchema#string

John P Guilinger

http://www.w3.org/2001/XMLSchema#string

Shengdar Q Tsai

http://www.w3.org/2001/XMLSchema#string

Vikram Pattanayak

http://www.w3.org/2001/XMLSchema#string

P2860

Rapid "open-source" engineering of customized zinc-finger nucleases for highly efficient gene modification

Targeted genome editing across species using ZFNs and TALENs

Revealing off-target cleavage specificities of zinc-finger nucleases by in vitro selection

A simple cipher governs DNA recognition by TAL effectors

Breaking the code of DNA binding specificity of TAL-type III effectors

How does multiple testing correction work?

Enhancing zinc-finger-nuclease activity with improved obligate heterodimeric architectures

A TALE nuclease architecture for efficient genome editing

An improved zinc-finger nuclease architecture for highly specific genome editing

Efficient targeted gene disruption in Xenopus embryos using engineered transcription activator-like effector nucleases (TALENs)

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429-435

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10.1038/NMETH.2845

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4

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11

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2014-02-16T00:00:00Z

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260218918

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1002278800

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24531420

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4010127

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