Localization of low molecular weight crystallin peptides in the aging human lens using a MALDI mass spectrometry imaging approach.
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Role of αA-crystallin-derived αA66-80 peptide in guinea pig lens crystallin aggregation and insolubilization.αA-crystallin peptide SDRDKFVIFLDVKHF accumulating in aging lens impairs the function of α-crystallin and induces lens protein aggregationAnalysis of tissue specimens by matrix-assisted laser desorption/ionization imaging mass spectrometry in biological and clinical research.Imaging of intact tissue sections: moving beyond the microscopeThe critical role of the central hydrophobic core (residues 71-77) of amyloid-forming αA66-80 peptide in α-crystallin aggregation: a systematic proline replacement study.Feasibility of depth profiling of animal tissue by ultrashort pulse laser ablationIdentification of histidine residues involved in Zn(2+) binding to αA- and αB-crystallin by chemical modification and MALDI TOF mass spectrometry.Realization of on-tissue protein identification by highly efficient in situ digestion with graphene-immobilized trypsin for MALDI imaging analysis.Spontaneous cyclization of polypeptides with a penultimate Asp, Asn or isoAsp at the N-terminus and implications for cleavage by aminopeptidase.Understanding the α-crystallin cell membrane conjunction.Degradation of an old human protein: age-dependent cleavage of γS-crystallin generates a peptide that binds to cell membranesProfiling of lens protease involved in generation of αA-66-80 crystallin peptide using an internally quenched protease substrateThe αA66-80 peptide interacts with soluble α-crystallin and induces its aggregation and precipitation: a contribution to age-related cataract formation.Lens Endogenous Peptide αA66-80 Generates Hydrogen Peroxide and Induces Cell Apoptosis.Lens crystallin modifications and cataract in transgenic mice overexpressing acylpeptide hydrolase.Spontaneous cleavage of proteins at serine and threonine is facilitated by zinc.Age-related cleavages of crystallins in human lens cortical fiber cells generate a plethora of endogenous peptides and high molecular weight complexes.Effect of Green Tea Polyphenol Epigallocatechin-3-gallate on the Aggregation of αA(66-80) Peptide, a Major Fragment of αA-crystallin Involved in Cataract Development.Molecular signatures of long-lived proteins: autolytic cleavage adjacent to serine residues.Separate mechanisms for age-related truncation and racemisation of peptide-bound serine.
P2860
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P2860
Localization of low molecular weight crystallin peptides in the aging human lens using a MALDI mass spectrometry imaging approach.
description
2010 nî lūn-bûn
@nan
2010 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Localization of low molecular ...... spectrometry imaging approach.
@ast
Localization of low molecular ...... spectrometry imaging approach.
@en
Localization of low molecular ...... spectrometry imaging approach.
@nl
type
label
Localization of low molecular ...... spectrometry imaging approach.
@ast
Localization of low molecular ...... spectrometry imaging approach.
@en
Localization of low molecular ...... spectrometry imaging approach.
@nl
prefLabel
Localization of low molecular ...... spectrometry imaging approach.
@ast
Localization of low molecular ...... spectrometry imaging approach.
@en
Localization of low molecular ...... spectrometry imaging approach.
@nl
P1476
Localization of low molecular ...... spectrometry imaging approach.
@en
P2093
J Andrew Aquilina
Jason D McArthur
P304
P356
10.1016/J.EXER.2010.04.010
P50
P577
2010-04-28T00:00:00Z