Disruption of RB/E2F-1 interaction by single point mutations in E2F-1 enhances S-phase entry and apoptosis.
about
Expression of BRC repeats in breast cancer cells disrupts the BRCA2-Rad51 complex and leads to radiation hypersensitivity and loss of G(2)/M checkpoint controlCloning and characterization of a novel Kruppel-associated box family transcriptional repressor that interacts with the retinoblastoma gene product, RBE2F-1 has dual roles depending on the cell cycleDeacetylation of the retinoblastoma tumour suppressor protein by SIRT1Novel mutants of NAB corepressors enhance activation by Egr transactivatorsRegulation of expression of nuclear and mitochondrial forms of human uracil-DNA glycosylaseRb and prohibitin target distinct regions of E2F1 for repression and respond to different upstream signalsThe transcriptional coregulator RIP140 represses E2F1 activity and discriminates breast cancer subtypesStructural basis for the recognition of the E2F transactivation domain by the retinoblastoma tumor suppressorThe inflammatory and normal transcriptome of mouse bladder detrusor and mucosaCrystal structure of the retinoblastoma tumor suppressor protein bound to E2F and the molecular basis of its regulationStructure of the retinoblastoma tumour-suppressor pocket domain bound to a peptide from HPV E7RB regulates pancreas development by stabilizing Pdx1Inhibition of mammalian cell proliferation by genetically selected peptide aptamers that functionally antagonize E2F activity.New tools for protein linkage mapping and general two-hybrid screening.Involvement of cell cycle elements, cyclin-dependent kinases, pRb, and E2F x DP, in B-amyloid-induced neuronal death.Human papillomavirus type 16 E7 binds to E2F1 and activates E2F1-driven transcription in a retinoblastoma protein-independent manner.The retinoblastoma tumor-suppressor gene, the exception that proves the ruleCell cycle regulators: mechanisms and their role in aetiology, prognosis, and treatment of cancer.Regulation of a senescence checkpoint response by the E2F1 transcription factor and p14(ARF) tumor suppressor.Histone deacetylation of RB-responsive promoters: requisite for specific gene repression but dispensable for cell cycle inhibition.Increased E2F1 activity induces skin tumors in mice heterozygous and nullizygous for p53.Cyclin-dependent kinases participate in death of neurons evoked by DNA-damaging agentsTranscriptional activation of histone genes requires NPAT-dependent recruitment of TRRAP-Tip60 complex to histone promoters during the G1/S phase transition.RRB1 and RRB2 encode maize retinoblastoma-related proteins that interact with a plant D-type cyclin and geminivirus replication protein.Identification of E2F1 as a positive transcriptional regulator for delta-catenin.The yeast two-hybrid system: forward and reverse.A transcriptionally inactive E2F-1 targets the MDM family of proteins for proteolytic degradation.E2F-1 binding affinity for pRb is not the only determinant of the E2F-1 activity.E2f3b plays an essential role in myogenic differentiation through isoform-specific gene regulation.E2F1 promotes cytokine mediated cell survival via a mechanism that is separable from its cell cycle regulatory effects.Effects of regulatory domains of specific isoforms of protein kinase C on growth control and apoptosis in MCF-7 breast cancer cells.Lovastatin induces apoptosis in a primitive neuroectodermal tumor cell line in association with RB down-regulation and loss of the G1 checkpoint.Isolation and characterization of the E2F-like gene in plants.Induction of apoptosis in cancer cells by tumor necrosis factor and butyrolactone, an inhibitor of cyclin-dependent kinases.Activity of the retinoblastoma family proteins, pRB, p107, and p130, during cellular proliferation and differentiation.Induction of DNA synthesis and apoptosis by regulated inactivation of a temperature-sensitive retinoblastoma proteinRb-independent E2F3 promotes cell proliferation and alters expression of genes involved in metabolism and inflammation.Characterization of the TnsD-attTn7 complex that promotes site-specific insertion of Tn7.Akt is activated in response to an apoptotic signal.
P2860
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P2860
Disruption of RB/E2F-1 interaction by single point mutations in E2F-1 enhances S-phase entry and apoptosis.
description
1996 nî lūn-bûn
@nan
1996 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
1996 թվականի հունվարին հրատարակված գիտական հոդված
@hy
1996年の論文
@ja
1996年論文
@yue
1996年論文
@zh-hant
1996年論文
@zh-hk
1996年論文
@zh-mo
1996年論文
@zh-tw
1996年论文
@wuu
name
Disruption of RB/E2F-1 interac ...... s S-phase entry and apoptosis.
@ast
Disruption of RB/E2F-1 interac ...... s S-phase entry and apoptosis.
@en
Disruption of RB/E2F-1 interac ...... s S-phase entry and apoptosis.
@nl
type
label
Disruption of RB/E2F-1 interac ...... s S-phase entry and apoptosis.
@ast
Disruption of RB/E2F-1 interac ...... s S-phase entry and apoptosis.
@en
Disruption of RB/E2F-1 interac ...... s S-phase entry and apoptosis.
@nl
prefLabel
Disruption of RB/E2F-1 interac ...... s S-phase entry and apoptosis.
@ast
Disruption of RB/E2F-1 interac ...... s S-phase entry and apoptosis.
@en
Disruption of RB/E2F-1 interac ...... s S-phase entry and apoptosis.
@nl
P2093
P2860
P356
P1476
Disruption of RB/E2F-1 interac ...... s S-phase entry and apoptosis.
@en
P2093
P2860
P304
P356
10.1073/PNAS.93.2.679
P407
P577
1996-01-01T00:00:00Z