Targeting SDF-1/CXCL12 with a ligand that prevents activation of CXCR4 through structure-based drug design
about
Peptidomimetics as a new generation of antimicrobial agents: current progressSolution Structure of CCL21 and Identification of a Putative CCR7 Binding SiteStructure-Based Identification of Novel Ligands Targeting Multiple Sites within a Chemokine-G-Protein-Coupled-Receptor InterfaceCrystallographic Structure of Truncated CCL21 and the Putative Sulfotyrosine-Binding SiteUbiquitin is a versatile scaffold protein for the generation of molecules with de novo binding and advantageous drug-like propertiesModulation of the CXC chemokine receptor 4 agonist activity of ubiquitin through C-terminal protein modification.Fragment-based optimization of small molecule CXCL12 inhibitors for antagonizing the CXCL12/CXCR4 interaction.Structural analysis of a novel small molecule ligand bound to the CXCL12 chemokine.The CXC chemokine receptor 4 ligands ubiquitin and stromal cell-derived factor-1α function through distinct receptor interactions.Structural determinants of ubiquitin-CXC chemokine receptor 4 interaction.Structure-based ligand discovery for the protein-protein interface of chemokine receptor CXCR4Experiment-Guided Molecular Modeling of Protein-Protein Complexes Involving GPCRsInitial assessment of the role of CXC chemokine receptor 4 after polytrauma.NMR in the Analysis of Functional Chemokine Interactions and Drug DiscoveryPreparation and Analysis of N-Terminal Chemokine Receptor Sulfopeptides Using Tyrosylprotein Sulfotransferase Enzymes.Sulfopeptide probes of the CXCR4/CXCL12 interface reveal oligomer-specific contacts and chemokine allostery.Chemokine oligomerization and interactions with receptors and glycosaminoglycans: the role of structural dynamics in functionImaging agents for the chemokine receptor 4 (CXCR4).The structural role of receptor tyrosine sulfation in chemokine recognition.CCR7 Sulfotyrosine Enhances CCL21 Binding.Pharmacological modulation of C-X-C motif chemokine receptor 4 influences development of acute respiratory distress syndrome after lung ischemia-reperfusion injury.Chemokines and their receptors: insights from molecular modeling and crystallography.Quantum dot-based screening system for discovery of g protein-coupled receptor agonists.Prodrugs of a CXC Chemokine-12 (CXCL12) Neutraligand Prevent Inflammatory Reactions in an Asthma Model in Vivo.Binding site identification and structure determination of protein-ligand complexes by NMR a semiautomated approach.Harnessing CXCR4 antagonists in stem cell mobilization, HIV infection, ischemic diseases, and oncology.Neutralizing nanobodies targeting diverse chemokines effectively inhibit chemokine functionSulfotyrosine recognition as marker for druggable sites in the extracellular space.Structural basis for chemokine recognition by a G protein-coupled receptor and implications for receptor activation.Chemokines from a Structural Perspective.Detecting Cell Surface Expression of the G Protein-Coupled Receptor CXCR4.Development and Validation of 2D Difference Intensity Analysis for Chemical Library Screening by Protein-Detected NMR.A sensitive and microscale method for drug screening combining affinity probes and single molecule fluorescence correlation spectroscopy.
P2860
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P2860
Targeting SDF-1/CXCL12 with a ligand that prevents activation of CXCR4 through structure-based drug design
description
2010 nî lūn-bûn
@nan
2010 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Targeting SDF-1/CXCL12 with a ...... gh structure-based drug design
@ast
Targeting SDF-1/CXCL12 with a ...... gh structure-based drug design
@en
Targeting SDF-1/CXCL12 with a ...... h structure-based drug design.
@nl
type
label
Targeting SDF-1/CXCL12 with a ...... gh structure-based drug design
@ast
Targeting SDF-1/CXCL12 with a ...... gh structure-based drug design
@en
Targeting SDF-1/CXCL12 with a ...... h structure-based drug design.
@nl
prefLabel
Targeting SDF-1/CXCL12 with a ...... gh structure-based drug design
@ast
Targeting SDF-1/CXCL12 with a ...... gh structure-based drug design
@en
Targeting SDF-1/CXCL12 with a ...... h structure-based drug design.
@nl
P2093
P2860
P356
P1476
Targeting SDF-1/CXCL12 with a ...... gh structure-based drug design
@en
P2093
Brian F Volkman
Christopher T Veldkamp
Francis C Peterson
P2860
P304
P356
10.1021/JA1002263
P407
P577
2010-06-01T00:00:00Z