Targeting the cyclin E-Cdk-2 complex represses lung cancer growth by triggering anaphase catastrophe
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Chromosomal instability and cancer: a complex relationship with therapeutic potentialCDK2 Inhibition Causes Anaphase Catastrophe in Lung Cancer through the Centrosomal Protein CP110A phenanthrene derived PARP inhibitor is an extra-centrosomes de-clustering agent exclusively eradicating human cancer cellsCyclin-dependent kinase-specific activity predicts the prognosis of stage I and stage II non-small cell lung cancer.Cyclin E transgenic mice: discovery tools for lung cancer biology, therapy, and prevention.Evidence for tankyrases as antineoplastic targets in lung cancer.Anaphase catastrophe is a target for cancer therapyBexarotene plus erlotinib suppress lung carcinogenesis independent of KRAS mutations in two clinical trials and transgenic models.Cyclin E involved in early stage carcinogenesis of esophageal adenocarcinoma by SNP DNA microarray and immunohistochemical studies.High expression of carbonic anhydrase IX is significantly associated with glandular lesions in gastroesophageal junction and with tumorigenesis markers BMI1, MCM4 and MCM7Specific CP110 Phosphorylation Sites Mediate Anaphase Catastrophe after CDK2 Inhibition: Evidence for Cooperation with USP33 Knockdown.Subtype-specific accumulation of intracellular zinc pools is associated with the malignant phenotype in breast cancer.Response to inhibition of smoothened in diverse epithelial cancer cells that lack smoothened or patched 1 mutations.Differences in degradation lead to asynchronous expression of cyclin E1 and cyclin E2 in cancer cells.Comparing histone deacetylase inhibitor responses in genetically engineered mouse lung cancer models and a window of opportunity trial in patients with lung cancerMechanisms of chromosomal instability.Targeting low molecular weight cyclin E (LMW-E) in breast cancer.Personalized therapies in the cancer "omics" eraCell cycle inhibitors for the treatment of NSCLC.Mitotic spindle multipolarity without centrosome amplification.New potential targets for treatment of Cushing's disease: epithelial growth factor receptor and cyclin-dependent kinases.Next-Generation CDK2/9 Inhibitors and Anaphase Catastrophe in Lung Cancer.Dinaciclib Induces Anaphase Catastrophe in Lung Cancer Cells via Inhibition of Cyclin-Dependent Kinases 1 and 2.Interference with ER-α enhances the therapeutic efficacy of the selective CDK inhibitor roscovitine towards ER-positive breast cancer cells.Prognostic Value of Molecular Markers and Implication for Molecular Targeted Therapies in Nasopharyngeal Carcinoma: An Update in an Era of New Targeted Molecules Development.Small molecules targeted to the microtubule-Hec1 interaction inhibit cancer cell growth through microtubule stabilization.Polo-like kinase 4 inhibition produces polyploidy and apoptotic death of lung cancers.N-terminus-modified Hec1 suppresses tumour growth by interfering with kinetochore-microtubule dynamics.The resveratrol analogue trimethoxystilbene inhibits cancer cell growth by inducing multipolar cell mitosis.
P2860
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P2860
Targeting the cyclin E-Cdk-2 complex represses lung cancer growth by triggering anaphase catastrophe
description
2009 nî lūn-bûn
@nan
2009 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
Targeting the cyclin E-Cdk-2 c ...... riggering anaphase catastrophe
@ast
Targeting the cyclin E-Cdk-2 c ...... riggering anaphase catastrophe
@en
Targeting the cyclin E-Cdk-2 c ...... iggering anaphase catastrophe.
@nl
type
label
Targeting the cyclin E-Cdk-2 c ...... riggering anaphase catastrophe
@ast
Targeting the cyclin E-Cdk-2 c ...... riggering anaphase catastrophe
@en
Targeting the cyclin E-Cdk-2 c ...... iggering anaphase catastrophe.
@nl
prefLabel
Targeting the cyclin E-Cdk-2 c ...... riggering anaphase catastrophe
@ast
Targeting the cyclin E-Cdk-2 c ...... riggering anaphase catastrophe
@en
Targeting the cyclin E-Cdk-2 c ...... iggering anaphase catastrophe.
@nl
P2093
P2860
P1476
Targeting the cyclin E-Cdk-2 c ...... riggering anaphase catastrophe
@en
P2093
Ethan Dmitrovsky
Fabrizio Galimberti
James DiRenzo
Jeff Settleman
Patricia Greninger
Sarah L Thompson
Simon R Green
Sreenath V Sharma
Vincent Memoli
P2860
P304
P356
10.1158/1078-0432.CCR-09-2151
P407
P577
2009-12-22T00:00:00Z