Inhibition of PI3K by PX-866 prevents transforming growth factor-alpha-induced pulmonary fibrosis.
about
Targeting EGFR signalling in chronic lung disease: therapeutic challenges and opportunitiesModulation of the mevalonate pathway by akt regulates macrophage survival and development of pulmonary fibrosisTargeting the isoprenoid pathway to abrogate progression of pulmonary fibrosisBone marrow-derived stromal cells are invasive and hyperproliferative and alter transforming growth factor-α-induced pulmonary fibrosisInhibition of myocardin-related transcription factor/serum response factor signaling decreases lung fibrosis and promotes mesenchymal cell apoptosis.Inhibition of mechanical stress-induced hypertrophic scar inflammation by emodin.Targeting phosphatidylinositol-3-kinase pathway for the treatment of Philadelphia-negative myeloproliferative neoplasms.Mesomesenchymal transition of pleural mesothelial cells is PI3K and NF-κB dependent.MEK-ERK pathway modulation ameliorates pulmonary fibrosis associated with epidermal growth factor receptor activationp70 ribosomal S6 kinase regulates subpleural fibrosis following transforming growth factor-α expression in the lungExploration of a potent PI3 kinase/mTOR inhibitor as a novel anti-fibrotic agent in IPFADAM17 substrate release in proximal tubule drives kidney fibrosisInhibition of the αvβ6 integrin leads to limited alteration of TGF-α-induced pulmonary fibrosis.Hypoxia-inducible factor inhibitors: a survey of recent patented compounds (2004 - 2010).PTEN loss in the continuum of common cancers, rare syndromes and mouse models.Natural products as kinase inhibitors.Lung carcinogenesis and fibrosis taken together: just coincidence?Discovery of Indenopyrazoles as a New Class of Hypoxia Inducible Factor (HIF)-1 Inhibitors.Dual targeting of MEK and PI3K pathways attenuates established and progressive pulmonary fibrosis.Increased survivin expression contributes to apoptosis-resistance in IPF fibroblasts."Scar-cinoma": viewing the fibrotic lung mesenchymal cell in the context of cancer biology.Unique and Redundant Functions of p70 Ribosomal S6 Kinase Isoforms Regulate Mesenchymal Cell Proliferation and Migration in Pulmonary Fibrosis.Fibrin Turnover and Organization of Pleural Injury: Bench to Bedside.Repositioning compounds from cancer drug discovery to IPF: PI3K inhibition.Phosphoinositide 3-kinase γ plays a critical role in bleomycin-induced pulmonary inflammation and fibrosis in mice.Hypoxia-inducible factors in mantle cell lymphoma: implication for an activated mTORC1→HIF-1α pathway.A phosphatidylinositol 3-kinase inhibitor strongly suppressed pulmonary vascular remodeling of allergic vasculitis in a murine model.
P2860
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P2860
Inhibition of PI3K by PX-866 prevents transforming growth factor-alpha-induced pulmonary fibrosis.
description
2009 nî lūn-bûn
@nan
2009 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
Inhibition of PI3K by PX-866 p ...... ha-induced pulmonary fibrosis.
@ast
Inhibition of PI3K by PX-866 p ...... ha-induced pulmonary fibrosis.
@en
type
label
Inhibition of PI3K by PX-866 p ...... ha-induced pulmonary fibrosis.
@ast
Inhibition of PI3K by PX-866 p ...... ha-induced pulmonary fibrosis.
@en
prefLabel
Inhibition of PI3K by PX-866 p ...... ha-induced pulmonary fibrosis.
@ast
Inhibition of PI3K by PX-866 p ...... ha-induced pulmonary fibrosis.
@en
P2093
P2860
P1476
Inhibition of PI3K by PX-866 p ...... ha-induced pulmonary fibrosis.
@en
P2093
Jeffrey A Whitsett
Machiko Ikegami
Matthew Fenchel
Stephanie Schmidt
Thomas R Korfhagen
William D Hardie
P2860
P304
P356
10.2353/AJPATH.2010.090123
P407
P577
2009-12-30T00:00:00Z