Constitutive WNT/beta-catenin signaling in murine Sertoli cells disrupts their differentiation and ability to support spermatogenesis
about
CTNNB1 signaling in sertoli cells downregulates spermatogonial stem cell activity via WNT4Dickkopf homolog 3 (DKK3) plays a crucial role upstream of WNT/β-CATENIN signaling for Sertoli cell mediated regulation of spermatogenesisTranslocator protein/peripheral benzodiazepine receptor is not required for steroid hormone biosynthesisGATA4 regulates Sertoli cell function and fertility in adult male miceAndrogen Receptor Coactivator ARID4B Is Required for the Function of Sertoli Cells in SpermatogenesisCryptorchidism in mice with an androgen receptor ablation in gubernaculum testis.Deletion of tuberous sclerosis 1 in somatic cells of the murine reproductive tract causes female infertility.Stromal deletion of the APC tumor suppressor in mice triggers development of endometrial cancerExpression of Glycogen synthase kinase 3-β (GSK3-β) gene in azoospermic men.Blood-testis barrier and spermatogenesis: lessons from genetically-modified mice.Role of β-catenin in post-meiotic male germ cell differentiationA naturally occurring Lgr4 splice variant encodes a soluble antagonist useful for demonstrating the gonadal roles of Lgr4 in mammals.Focal Mullerian duct retention in male mice with constitutively activated beta-catenin expression in the Mullerian duct mesenchymeA unique combination of male germ cell miRNAs coordinates gonocyte differentiation.β-CateninC429S mice exhibit sterility consequent to spatiotemporally sustained Wnt signalling in the internal genitalia.Profiling spermatogenic failure in adult testes bearing Sox9-deficient Sertoli cells identifies genes involved in feminization, inflammation and stress.Spermatogonial stem cells, infertility and testicular cancer.Expression of dominant-negative thyroid hormone receptor alpha1 in Leydig and Sertoli cells demonstrates no additional defect compared with expression in Sertoli cells onlyAdenomatous polyposis coli (APC) is essential for maintaining the integrity of the seminiferous epithelium.Distinct germline progenitor subsets defined through Tsc2-mTORC1 signaling.Combined loss of the GATA4 and GATA6 transcription factors in male mice disrupts testicular development and confers adrenal-like function in the testes.Environmental contaminants: Is male reproductive health at risk?AMPK: a master energy regulator for gonadal function.GATA4 is a critical regulator of gonadectomy-induced adrenocortical tumorigenesis in mice.Aberrant Wnt/β-Catenin Signaling Pathway in Testis of Azoospermic Men.Altered LKB1/AMPK/TSC1/TSC2/mTOR signaling causes disruption of Sertoli cell polarity and spermatogenesisIn vivo evidence for the crucial role of SF1 in steroid-producing cells of the testis, ovary and adrenal gland.The Müllerian inhibiting substance type 2 receptor suppresses tumorigenesis in testes with sustained β-catenin signalingMechanism of Wnt signaling induced down regulation of mrhl long non-coding RNA in mouse spermatogonial cellsDynamics of the Transcriptome during Human Spermatogenesis: Predicting the Potential Key Genes Regulating Male Gametes Generation.PTEN loss and HOXA10 expression are associated with ovarian endometrioid adenocarcinoma differentiation and progression.Physiopathological aspects of the Wnt/β-catenin signaling pathway in the male reproductive systemGerm cell specific overactivation of WNT/βcatenin signalling has no effect on folliculogenesis but causes fertility defects due to abnormal foetal developmentmTOR Regulates Gap Junction Alpha-1 Protein Trafficking in Sertoli Cells and Is Required for the Maintenance of Spermatogenesis in Mice.Does murine spermatogenesis require WNT signalling? A lesson from Gpr177 conditional knockout mouse modelsGerm cell-specific sustained activation of Wnt signalling perturbs spermatogenesis in aged mice, possibly through non-coding RNAs.CHIR99021 combined with retinoic acid promotes the differentiation of primordial germ cells from human embryonic stem cells.Selective accumulation of germ-line associated gene products in early development of the sea star and distinct differences from germ-line development in the sea urchin.Estimated diversity of messenger RNAs in each murine spermatozoa and their potential function during early zygotic development.Normal fertility in male mice with deletion of β-catenin gene in germ cells.
P2860
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P2860
Constitutive WNT/beta-catenin signaling in murine Sertoli cells disrupts their differentiation and ability to support spermatogenesis
description
2009 nî lūn-bûn
@nan
2009 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
Constitutive WNT/beta-catenin ...... ity to support spermatogenesis
@ast
Constitutive WNT/beta-catenin ...... ity to support spermatogenesis
@en
type
label
Constitutive WNT/beta-catenin ...... ity to support spermatogenesis
@ast
Constitutive WNT/beta-catenin ...... ity to support spermatogenesis
@en
prefLabel
Constitutive WNT/beta-catenin ...... ity to support spermatogenesis
@ast
Constitutive WNT/beta-catenin ...... ity to support spermatogenesis
@en
P2093
P2860
P1476
Constitutive WNT/beta-catenin ...... ity to support spermatogenesis
@en
P2093
LiHua Zhang
Makoto M Taketo
Poonam Rani
Pradeep S Tanwar
P2860
P304
P356
10.1095/BIOLREPROD.109.079335
P407
P577
2009-09-30T00:00:00Z