Stability and CDR composition biases enrich binder functionality landscapes.
about
Engineered IgG1-Fc--one fragment to bind them allArtificial affinity proteins as ligands of immunoglobulinsProtein-protein fusion catalyzed by sortase AUse of (64)Cu-labeled fibronectin domain with EGFR-overexpressing tumor xenograft: molecular imaging.A Nonpolycationic Fully Proteinaceous Multiagent System for Potent Targeted Delivery of siRNA.Adnectins: engineered target-binding protein therapeuticsEngineering hepatocyte growth factor fragments with high stability and activity as Met receptor agonists and antagonists.Epidermal growth factor receptor downregulation by small heterodimeric binding proteinsEpitope-guided engineering of monobody binders for in vivo inhibition of Erk-2 signaling.Isolation and Characterization of a Monobody with a Fibronectin Domain III Scaffold That Specifically Binds EphA2.High-Throughput Ligand Discovery Reveals a Sitewise Gradient of Diversity in Broadly Evolved Hydrophilic Fibronectin DomainsA 45-Amino-Acid Scaffold Mined from the PDB for High-Affinity Ligand Engineering.Strong Enrichment of Aromatic Residues in Binding Sites from a Charge-neutralized Hyperthermostable Sso7d Scaffold Library.Co-evolution of affinity and stability of grafted amyloid-motif domain antibodies.Designed hydrophilic and charge mutations of the fibronectin domain: towards tailored protein biodistribution.An enhanced approach for engineering thermally stable proteins using yeast display.A Gradient of Sitewise Diversity Promotes Evolutionary Fitness for Binder Discovery in a Three-Helix Bundle Protein Scaffold.Natural and man-made V-gene repertoires for antibody discovery.Efficient affinity maturation of antibody variable domains requires co-selection of compensatory mutations to maintain thermodynamic stability.Geometry and expression enhance enrichment of functional yeast-displayed ligands via cell panning.Recent progress in protein-protein interaction study for EGFR-targeted therapeutics.Information-Theoretic Considerations Concerning the Origin of Life.Adnectin-Based Design of Chimeric Antigen Receptor for T Cell Engineering.Local and global anatomy of antibody-protein antigen recognition.Fn3 proteins engineered to recognize tumor biomarker mesothelin internalize upon binding.
P2860
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P2860
Stability and CDR composition biases enrich binder functionality landscapes.
description
2010 nî lūn-bûn
@nan
2010 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2010年の論文
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2010年学术文章
@wuu
2010年学术文章
@zh-cn
2010年学术文章
@zh-hans
2010年学术文章
@zh-my
2010年学术文章
@zh-sg
2010年學術文章
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name
Stability and CDR composition biases enrich binder functionality landscapes.
@ast
Stability and CDR composition biases enrich binder functionality landscapes.
@en
type
label
Stability and CDR composition biases enrich binder functionality landscapes.
@ast
Stability and CDR composition biases enrich binder functionality landscapes.
@en
prefLabel
Stability and CDR composition biases enrich binder functionality landscapes.
@ast
Stability and CDR composition biases enrich binder functionality landscapes.
@en
P2093
P2860
P1476
Stability and CDR composition biases enrich binder functionality landscapes.
@en
P2093
Benjamin J Hackel
K Dane Wittrup
Margaret E Ackerman
P2860
P356
10.1016/J.JMB.2010.06.004
P407
P577
2010-06-09T00:00:00Z