Transgenic mice expressing the Tyr437His mutant of human myocilin protein develop glaucoma.
about
Myocilin, a glaucoma-associated protein, promotes cell migration through activation of integrin-focal adhesion kinase-serine/threonine kinase signaling pathwayOverexpression of optineurin E50K disrupts Rab8 interaction and leads to a progressive retinal degeneration in miceMyocilin is a modulator of Wnt signalingMyocilin stimulates osteogenic differentiation of mesenchymal stem cells through mitogen-activated protein kinase signalingExtracellular matrix in the trabecular meshwork: intraocular pressure regulation and dysregulation in glaucomaOlfactomedin proteins: central players in development and diseaseExperimentally Induced Mammalian Models of GlaucomaMyocilin interacts with syntrophins and is member of dystrophin-associated protein complexMutant WDR36 directly affects axon growth of retinal ganglion cells leading to progressive retinal degeneration in miceRodent models of glaucoma.Enteric nervous system abnormalities are present in human necrotizing enterocolitis: potential neurotransplantation therapyFunctional role of proteolytic processing of recombinant myocilin in self-aggregationExpression of myocilin mutants sensitizes cells to oxidative stress-induced apoptosis: implication for glaucoma pathogenesisGlaucoma: genes, phenotypes, and new directions for therapy.Olfactomedin domain-containing proteins: possible mechanisms of action and functions in normal development and pathology.Transgenic mice expressing mutated Tyr437His human myocilin develop progressive loss of retinal ganglion cell electrical responsiveness and axonopathy with normal iop.Differential susceptibility to experimental glaucoma among 3 mouse strains using bead and viscoelastic injectionAqueous humor rapidly stimulates myocilin secretion from human trabecular meshwork cells.Establishment of inducible wild type and mutant myocilin-GFP-expressing RGC5 cell linesThe importance of and potential for continuous monitoring of intraocular pressure.Interaction of recombinant myocilin with the matricellular protein SPARC: functional implicationsMouse models of retinal ganglion cell death and glaucoma.Translational models of ocular disease.Anterior segment dysgenesis and early-onset glaucoma in nee mice with mutation of Sh3pxd2bThe stability of myocilin olfactomedin domain variants provides new insight into glaucoma as a protein misfolding disorder.A dominant-negative mutation of mouse Lmx1b causes glaucoma and is semi-lethal via LDB1-mediated dimerization [corrected].Reduction of ER stress via a chemical chaperone prevents disease phenotypes in a mouse model of primary open angle glaucoma.Structural basis for misfolding in myocilin-associated glaucoma.Aqueous humor outflow: dynamics and disease.Myocilin mutations among POAG patients from two populations of Tamil Nadu, South India, a comparative analysis.Mutated myocilin and heterozygous Sod2 deficiency act synergistically in a mouse model of open-angle glaucoma.Amyloid fibril formation by the glaucoma-associated olfactomedin domain of myocilin.No association of genetic polymorphisms in CYP1B1 with primary open-angle glaucoma: a meta- and gene-based analysis.Aberrant Collagen Composition of the Trabecular Meshwork Results in Reduced Aqueous Humor Drainage and Elevated IOP in MMP-9 Null Mice.Using genetic mouse models to gain insight into glaucoma: Past results and future possibilities.Mutant human myocilin induces strain specific differences in ocular hypertension and optic nerve damage in mice.Heterozygous expression of myocilin glaucoma mutants increases secretion of the mutant forms and reduces extracellular processed myocilin.Glaucoma-associated myocilin: a better understanding but much more to learn.Heterozygous Pitx2 Null Mice Accurately Recapitulate the Ocular Features of Axenfeld-Rieger Syndrome and Congenital Glaucoma.Myocilin regulates cell proliferation and survival
P2860
Q24306176-98CB508D-7B24-4880-B053-2BC41F559BD0Q24306510-3A35F076-0BCE-407E-A065-72BF43F5B57EQ24328948-DE96D314-32CD-4988-80B9-F249129A0203Q24339483-04A0C3BD-B090-4C35-ADE3-96A3ABF1E4A5Q26851287-8CC7DA6E-AE6B-429D-9994-EB53F5407EABQ26851669-B6481C4D-6522-4FA8-A25E-35C6F14DB0DBQ27022424-7ACB4D43-204A-4416-997D-06FCFFB3B098Q28586144-B33D222C-8517-4D07-824B-CBAAE2C236E3Q28586810-FC0C827F-3EE9-4F79-BAA5-99BE1E3FCBF3Q33698065-538D0AEC-02A4-48FD-9FE9-B564AC75C8ADQ33745991-31E53BF6-0B67-4630-B9E9-47308BC6AB79Q33847413-0641AE9B-6D4C-44B3-934E-71E90DD006F5Q33882506-EF7680DD-ED98-418F-A3BF-A680EEF75896Q34090204-99283B9F-C52E-4C5C-9789-DE1B98A2DE44Q34116120-57954723-8ACC-4325-9C33-E2AC84D3F952Q34159558-B183CCCB-1497-4E1C-8BE6-4541EA53D49AQ34196101-903C6326-56F7-452B-9635-1F0D9ECF4B64Q34361564-6749DEBD-508B-41A2-96D7-52971833ACD3Q34452059-EB27CF1C-76C8-4D4A-A129-CB851D677E33Q34544090-31660ACA-AF67-4510-9132-71024B9A5C27Q34646595-9F90D4E0-E8C1-4315-83F1-A4398A2B5307Q34664035-12B13C56-FDF8-46A0-BDD9-34AFEA1FBEAFQ34764453-B3D4D978-ACE6-4B12-BF2C-3E93B1C78B0EQ34936970-9BF7818D-A240-4A62-A731-E87765822425Q35083487-6877F93D-44D2-4B6E-AF74-5852BAF3D34FQ35165296-C87A4076-8296-42D9-A8F7-C482154E4482Q35187142-386A28F5-6691-48EC-835E-0923F103244CQ35234066-DB61B97F-413B-45BE-A83B-5259B2032D37Q35608780-5E271818-588B-4554-A63A-CEE05E8EA7ECQ35629081-9D120880-6ACD-4192-9E4F-E52C78BA341DQ35662064-41213656-7AF7-459D-8F76-B04347E9850AQ35881767-64010BE7-BB7C-4F19-81DC-6BC5F9A869DBQ35883344-0093D456-7171-41B4-A45F-97D16FA31AC9Q36184485-ED50A144-C34F-49C1-81BB-A308BEC71BDBQ36236937-2065D41D-5B82-44A8-9036-BA695D096C1BQ36730478-EEE47148-1863-41EA-9B66-16AA0A5D770AQ36978194-91498391-26B3-4A4D-879C-A0982AAD7174Q37193799-1D33B013-D4FA-4897-A9DE-87EBF25A7B1FQ37292402-0C674AA7-8D2B-4A74-AA31-243E34CB732FQ37683314-F16C19B9-470A-4DB9-A325-76256957971A
P2860
Transgenic mice expressing the Tyr437His mutant of human myocilin protein develop glaucoma.
description
2008 nî lūn-bûn
@nan
2008 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
Transgenic mice expressing the ...... ilin protein develop glaucoma.
@ast
Transgenic mice expressing the ...... ilin protein develop glaucoma.
@en
type
label
Transgenic mice expressing the ...... ilin protein develop glaucoma.
@ast
Transgenic mice expressing the ...... ilin protein develop glaucoma.
@en
prefLabel
Transgenic mice expressing the ...... ilin protein develop glaucoma.
@ast
Transgenic mice expressing the ...... ilin protein develop glaucoma.
@en
P2093
P2860
P356
P1476
Transgenic mice expressing the ...... ilin protein develop glaucoma.
@en
P2093
Oleg Grinchuk
Stanislav I Tomarev
P2860
P304
P356
10.1167/IOVS.07-1339
P407
P577
2008-05-01T00:00:00Z