The host protease TMPRSS2 plays a major role in in vivo replication of emerging H7N9 and seasonal influenza viruses.
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Modeling Influenza Virus Infection: A Roadmap for Influenza ResearchDESC1 and MSPL activate influenza A viruses and emerging coronaviruses for host cell entry.Identification of TMPRSS2 as a Susceptibility Gene for Severe 2009 Pandemic A(H1N1) Influenza and A(H7N9) Influenza.TMPRSS2 Independency for Haemagglutinin Cleavage In Vivo Differentiates Influenza B Virus from Influenza A Virus.A peptide-based approach to evaluate the adaptability of influenza A virus to humans based on its hemagglutinin proteolytic cleavage site.Non-human primate orthologues of TMPRSS2 cleave and activate the influenza virus hemagglutinin.A serpin shapes the extracellular environment to prevent influenza A virus maturationA mutant H3N2 influenza virus uses an alternative activation mechanism in TMPRSS2 knockout mice by loss of an oligosaccharide in the hemagglutinin stalk region.Preliminary Proteomic Analysis of A549 Cells Infected with Avian Influenza Virus H7N9 and Influenza A Virus H1N1Respiratory protease/antiprotease balance determines susceptibility to viral infection and can be modified by nutritional antioxidantsCathepsin L Helps to Defend Mice from Infection with Influenza A.Different residues in the SARS-CoV spike protein determine cleavage and activation by the host cell protease TMPRSS2.Influenza A Virus-Induced Expression of a GalNAc Transferase, GALNT3, via MicroRNAs Is Required for Enhanced Viral Replication.The Proteolytic Activation of (H3N2) Influenza A Virus Hemagglutinin Is Facilitated by Different Type II Transmembrane Serine Proteases.Identification of Nafamostat as a Potent Inhibitor of Middle East Respiratory Syndrome Coronavirus S Protein-Mediated Membrane Fusion Using the Split-Protein-Based Cell-Cell Fusion Assay.Kallikrein-Related Peptidase 5 Contributes to H3N2 Influenza Virus Infection in Human Lungs.TMPRSS12 Is an Activating Protease for Subtype B Avian Metapneumovirus.TMPRSS2 Isoform 1 Activates Respiratory Viruses and Is Expressed in Viral Target Cells.Transmembrane serine protease TMPRSS2 activates hepatitis C virus infection.Role of Host Genes in Influenza Virus Replication.Modification of the hemagglutinin cleavage site allows indirect activation of avian influenza virus H9N2 by bacterial staphylokinaseA single amino acid substitution within the Paramyxovirus Sendai virus nucleoprotein is a critical determinant for production of IFN-beta-inducing copyback-type defective interfering genomes.Zygote injection of CRISPR/Cas9 RNA successfully modifies the target gene without delaying blastocyst development or altering the sex ratio in pigs.Enterokinase Enhances Influenza A Virus Infection by Activating Trypsinogen in Human Cell Lines.TMPRSS11A activates the influenza A virus hemagglutinin and the MERS coronavirus spike protein and is insensitive against blockade by HAI-1Exchange of amino acids in the H1-haemagglutinin to H3 residues is required for efficient influenza A virus replication and pathology in Tmprss2 knock-out mice
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The host protease TMPRSS2 plays a major role in in vivo replication of emerging H7N9 and seasonal influenza viruses.
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The host protease TMPRSS2 play ...... nd seasonal influenza viruses.
@ast
The host protease TMPRSS2 play ...... nd seasonal influenza viruses.
@en
type
label
The host protease TMPRSS2 play ...... nd seasonal influenza viruses.
@ast
The host protease TMPRSS2 play ...... nd seasonal influenza viruses.
@en
prefLabel
The host protease TMPRSS2 play ...... nd seasonal influenza viruses.
@ast
The host protease TMPRSS2 play ...... nd seasonal influenza viruses.
@en
P2093
P2860
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P1433
P1476
The host protease TMPRSS2 play ...... nd seasonal influenza viruses.
@en
P2093
Akira Ainai
Eri Nobusawa
Hideki Hasegawa
Katsuhiro Komase
Katsumi Maenaka
Kazuhiko Kanou
Kazuya Nakamura
Kazuya Shirato
Kouji Sakai
Maino Tahara
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P304
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10.1128/JVI.03677-13
P577
2014-03-05T00:00:00Z