Formation and fate of a sulfenic acid intermediate in the metabolic activation of the antithrombotic prodrug prasugrel.
about
Mechanism-based inactivation of human cytochrome P450 2B6 by clopidogrel: involvement of both covalent modification of cysteinyl residue 475 and loss of hemeFormation, reactivity, and antiplatelet activity of mixed disulfide conjugates of clopidogrel.Potent and Orally Bioavailable Antiplatelet Agent, PLD-301, with the Potential of Overcoming Clopidogrel ResistanceCytochrome P450-activated prodrugs.Identification of the Significant Involvement and Mechanistic Role of CYP3A4/5 in Clopidogrel BioactivationInhibitory Effects of Trapping Agents of Sulfur Drug Reactive Intermediates against Major Human Cytochrome P450 Isoforms.S-Glucuronidation of 7-mercapto-4-methylcoumarin by human UDP glycosyltransferases in genetically engineered fission yeast cells.Clarifying the importance of CYP2C19 and PON1 in the mechanism of clopidogrel bioactivation and in vivo antiplatelet response.The discovery and development of prasugrel.
P2860
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P2860
Formation and fate of a sulfenic acid intermediate in the metabolic activation of the antithrombotic prodrug prasugrel.
description
2010 nî lūn-bûn
@nan
2010 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Formation and fate of a sulfen ...... ithrombotic prodrug prasugrel.
@ast
Formation and fate of a sulfen ...... ithrombotic prodrug prasugrel.
@en
type
label
Formation and fate of a sulfen ...... ithrombotic prodrug prasugrel.
@ast
Formation and fate of a sulfen ...... ithrombotic prodrug prasugrel.
@en
prefLabel
Formation and fate of a sulfen ...... ithrombotic prodrug prasugrel.
@ast
Formation and fate of a sulfen ...... ithrombotic prodrug prasugrel.
@en
P2093
P356
P1476
Formation and fate of a sulfen ...... ithrombotic prodrug prasugrel.
@en
P2093
Gildas Bertho
Patrick M Dansette
Stéphanie Thébault
P304
P356
10.1021/TX1001332
P577
2010-07-01T00:00:00Z