Separating the mechanism-based and off-target actions of cholesteryl ester transfer protein inhibitors with CETP gene polymorphisms. - Wikidata - awgldk - TriplyDB

Separating the mechanism-based and off-target actions of cholesteryl ester transfer protein inhibitors with CETP gene polymorphisms.

Separating the mechanism-based and off-target actions of cholesteryl ester transfer protein inhibitors with CETP gene polymorphisms.

http://www.wikidata.org/entity/Q33612543

about

Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip The role of advanced lipid testing in the prediction of cardiovascular disease The Active for Life Year 5 (AFLY5) school-based cluster randomised controlled trial: effect on potential mediators.Harnessing publicly available genetic data to prioritize lipid modifying therapeutic targets for prevention of coronary heart disease based on dysglycemic risk.Association between Six CETP Polymorphisms and Metabolic Syndrome in Uyghur Adults from Xinjiang, China.Gene-environment interactions of CETP gene variation in a high cardiovascular risk Mediterranean population Cholesteryl ester transfer protein inhibition as a strategy to reduce cardiovascular risk.Cholesteryl ester transfer protein polymorphism (TaqIB) associates with risk in postinfarction patients with high C-reactive protein and high-density lipoprotein cholesterol levels.Comparative analysis of genome-wide association studies signals for lipids, diabetes, and coronary heart disease: Cardiovascular Biomarker Genetics Collaboration.The interleukin-6 receptor as a target for prevention of coronary heart disease: a mendelian randomisation analysis HDL dysfunction in diabetes: causes and possible treatments.Vulnerable plaque: from bench to bedside; local pacification versus systemic therapy.Metabolomic Profiling of Statin Use and Genetic Inhibition of HMG-CoA Reductase A phenome-wide association study of a lipoprotein-associated phospholipase A2 loss-of-function variant in 90 000 Chinese adults.Selecting instruments for Mendelian randomization in the wake of genome-wide association studies.PCSK9 genetic variants and risk of type 2 diabetes: a mendelian randomisation study.Translating genomics into improved healthcare.Cholesteryl ester transfer protein inhibition in cardiovascular risk management: ongoing trials will end the confusion.On- and off-target pharmacology of torcetrapib: current understanding and implications for the structure activity relationships (SAR), discovery and development of cholesteryl ester-transfer protein (CETP) inhibitors.Rationale for cholesteryl ester transfer protein inhibition.An update on the clinical development of dalcetrapib (RO4607381), a cholesteryl ester transfer protein modulator that increases HDL cholesterol levels.Developing treatments for pulmonary arterial hypertension Identification of a novel, non-tetrahydroquinoline variant of the cholesteryl ester transfer protein (CETP) inhibitor torcetrapib, with improved aqueous solubility.Genetic risk factors and Mendelian randomization in cardiovascular disease.LDL, HDL, VLDL, and CVD Prevention: Lessons from Genetics?The potential of cholesteryl ester transfer protein as a therapeutic target.Mendelian Randomization Analyses for Selection of Therapeutic Targets for Cardiovascular Disease Prevention: a Note of Circumspection.The future of epidemiology: methods or matter?Insight into rheumatological cause and effect through the use of Mendelian randomization.The DEFINE study: a bright future for CETP inhibitors?Genetic Association of Lipids and Lipid Drug Targets With Abdominal Aortic Aneurysm: A Meta-analysis.The druggable genome and support for target identification and validation in drug development.Mendelian randomization: where are we now and where are we going?Using genetics to explore whether the cholesterol-lowering drug ezetimibe may cause an increased risk of cancer.Using Mendelian randomization to assess and develop clinical interventions: limitations and benefits.

P2860

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P2860

Separating the mechanism-based and off-target actions of cholesteryl ester transfer protein inhibitors with CETP gene polymorphisms.

http://www.wikidata.org/entity/Q33612543

description

2009 nî lūn-bûn

@nan

2009 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2009 թվականի դեկտեմբերին հրատարակված գիտական հոդված

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2009年の論文

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2009年論文

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2009年論文

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2009年論文

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2009年論文

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2009年論文

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2009年论文

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Separating the mechanism-based ...... with CETP gene polymorphisms.

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Separating the mechanism-based ...... with CETP gene polymorphisms.

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Separating the mechanism-based ...... with CETP gene polymorphisms.

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Separating the mechanism-based ...... with CETP gene polymorphisms.

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Separating the mechanism-based ...... with CETP gene polymorphisms.

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Aaron Isaacs

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Akimoto Goto

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Anton Sandhofer

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Benjamin D Horne

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Bernhard Paulweber

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François Cambien

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Gerjan Navis

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P2860

A genome-wide association study identifies protein quantitative trait loci (pQTLs)

'Mendelian randomization': can genetic epidemiology contribute to understanding environmental determinants of disease?

Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans

Polymorphism in the CETP gene region, HDL cholesterol, and risk of future myocardial infarction: Genomewide analysis among 18 245 initially healthy women from the Women's Genome Health Study

Measuring inconsistency in meta-analyses

Torcetrapib and carotid intima-media thickness in mixed dyslipidaemia (RADIANCE 2 study): a randomised, double-blind trial

Raising high-density lipoprotein in humans through inhibition of cholesteryl ester transfer protein: an initial multidose study of torcetrapib

Effects of an inhibitor of cholesteryl ester transfer protein on HDL cholesterol

Newly identified loci that influence lipid concentrations and risk of coronary artery disease

Efficacy and safety of torcetrapib, a novel cholesteryl ester transfer protein inhibitor, in individuals with below-average high-density lipoprotein cholesterol levels

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George Davey Smith

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Cornelia M. van Duijn

Ramachandran S. Vasan

Pim van der Harst

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2009-12-21T00:00:00Z

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20026784

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