Discovery of 2-Alkyl-1-arylsulfonylprolinamides as 11β-Hydroxysteroid Dehydrogenase Type 1 Inhibitors - Wikidata - awgldk - TriplyDB

Discovery of 2-Alkyl-1-arylsulfonylprolinamides as 11β-Hydroxysteroid Dehydrogenase Type 1 Inhibitors

Discovery of 2-Alkyl-1-arylsulfonylprolinamides as 11β-Hydroxysteroid Dehydrogenase Type 1 Inhibitors

http://www.wikidata.org/entity/Q33630245

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Optimization of 1,2,4-Triazolopyridines as Inhibitors of Human 11β-Hydroxysteroid Dehydrogenase Type 1 (11β-HSD-1)Synthesis, crystal structure, anti-HIV, and antiproliferative activity of new oxadiazole and thiazole analogs

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Discovery of 2-Alkyl-1-arylsulfonylprolinamides as 11β-Hydroxysteroid Dehydrogenase Type 1 Inhibitors

http://www.wikidata.org/entity/Q33630245

description

2012 nî lūn-bûn

@nan

2012 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած

@hyw

2012 թվականի սեպտեմբերին հրատարակված գիտական հոդված

@hy

2012年の論文

@ja

2012年論文

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2012年論文

@zh-hant

2012年論文

@zh-hk

2012年論文

@zh-mo

2012年論文

@zh-tw

2012年论文

@wuu

name

Discovery of 2-Alkyl-1-arylsul ...... ehydrogenase Type 1 Inhibitors

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Discovery of 2-Alkyl-1-arylsul ...... ehydrogenase Type 1 Inhibitors

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type

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Discovery of 2-Alkyl-1-arylsul ...... ehydrogenase Type 1 Inhibitors

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Discovery of 2-Alkyl-1-arylsul ...... ehydrogenase Type 1 Inhibitors

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Discovery of 2-Alkyl-1-arylsul ...... ehydrogenase Type 1 Inhibitors

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Discovery of 2-Alkyl-1-arylsul ...... ehydrogenase Type 1 Inhibitors

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ACS Medicinal Chemistry Letters

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Discovery of 2-Alkyl-1-arylsul ...... ehydrogenase Type 1 Inhibitors

@en

P2093

Bing Xiong

http://www.w3.org/2001/XMLSchema#string

Chen Ma

http://www.w3.org/2001/XMLSchema#string

Guangxin Xia

http://www.w3.org/2001/XMLSchema#string

Haiyan Liu

http://www.w3.org/2001/XMLSchema#string

Hua Li

http://www.w3.org/2001/XMLSchema#string

Jiajun Xu

http://www.w3.org/2001/XMLSchema#string

Jianxin Yu

http://www.w3.org/2001/XMLSchema#string

Jingkang Shen

http://www.w3.org/2001/XMLSchema#string

Lin Liu

http://www.w3.org/2001/XMLSchema#string

Ping Li

http://www.w3.org/2001/XMLSchema#string

P2860

Discovery of novel, potent benzamide inhibitors of 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) exhibiting oral activity in an enzyme inhibition ex vivo model

The development and SAR of pyrrolidine carboxamide 11beta-HSD1 inhibitors

The 11-beta-hydroxysteroid dehydrogenase type 1 inhibitor INCB13739 improves hyperglycemia in patients with type 2 diabetes inadequately controlled by metformin monotherapy.

Transgenic amplification of glucocorticoid action in adipose tissue causes high blood pressure in mice.

11beta-HSD1 inhibition ameliorates metabolic syndrome and prevents progression of atherosclerosis in mice.

The role of 11beta-hydroxysteroid dehydrogenase in metabolic disease and therapeutic potential of 11beta-hsd1 inhibitors.

Inhibitors of 11β-hydroxysteroid dehydrogenase type 1 in antidiabetic therapy.

Discovery of novel sulfonamides as potent and selective inhibitors against human and mouse 11β-hydroxysteroid dehydrogenase type 1.

Synthesis and biological evaluation of cyclic sulfamide derivatives as 11β-hydroxysteroid dehydrogenase 1 inhibitors.

Demonstration of proof of mechanism and pharmacokinetics and pharmacodynamic relationship with 4'-cyano-biphenyl-4-sulfonic acid (6-amino-pyridin-2-yl)-amide (PF-915275), an inhibitor of 11 -hydroxysteroid dehydrogenase type 1, in cynomolgus monkeys

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793-798

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scholarly article

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10.1021/ML300144N

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10

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3

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2012-09-20T00:00:00Z

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262883034

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24900382

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4025654

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