ICP27 phosphorylation site mutants display altered functional interactions with cellular export factors Aly/REF and TAP/NXF1 but are able to bind herpes simplex virus 1 RNA
about
Structural Basis for the Recognition of Cellular mRNA Export Factor REF by Herpes Viral Proteins HSV-1 ICP27 and HVS ORF57Herpes simplex virus 1 regulatory protein ICP27 undergoes a head-to-tail intramolecular interaction.Three arginine residues within the RGG box are crucial for ICP27 binding to herpes simplex virus 1 GC-rich sequences and for efficient viral RNA export.Head-to-tail intramolecular interaction of herpes simplex virus type 1 regulatory protein ICP27 is important for its interaction with cellular mRNA export receptor TAP/NXF1.Stability of structured Kaposi's sarcoma-associated herpesvirus ORF57 protein is regulated by protein phosphorylation and homodimerization.CK2 inhibitors increase the sensitivity of HSV-1 to interferon-β.Structure of the C-Terminal Domain of the Multifunctional ICP27 Protein from Herpes Simplex Virus 1Herpes simplex virus 1 VP22 regulates translocation of multiple viral and cellular proteins and promotes neurovirulence.The structure of the folded domain from the signature multifunctional protein ICP27 from herpes simplex virus-1 reveals an intertwined dimer.mRNA decay during herpes simplex virus (HSV) infections: mutations that affect translation of an mRNA influence the sites at which it is cleaved by the HSV virion host shutoff (Vhs) protein.The interaction of the cellular export adaptor protein Aly/REF with ICP27 contributes to the efficiency of herpes simplex virus 1 mRNA export.The many roles of the highly interactive HSV protein ICP27, a key regulator of infection.Duck enteritis virus (DEV) UL54 protein, a novel partner, interacts with DEV UL24 protein.pUL69 of Human Cytomegalovirus Recruits the Cellular Protein Arginine Methyltransferase 6 via a Domain That Is Crucial for mRNA Export and Efficient Viral Replication
P2860
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P2860
ICP27 phosphorylation site mutants display altered functional interactions with cellular export factors Aly/REF and TAP/NXF1 but are able to bind herpes simplex virus 1 RNA
description
2009 nî lūn-bûn
@nan
2009 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
ICP27 phosphorylation site mut ...... ind herpes simplex virus 1 RNA
@ast
ICP27 phosphorylation site mut ...... ind herpes simplex virus 1 RNA
@en
type
label
ICP27 phosphorylation site mut ...... ind herpes simplex virus 1 RNA
@ast
ICP27 phosphorylation site mut ...... ind herpes simplex virus 1 RNA
@en
prefLabel
ICP27 phosphorylation site mut ...... ind herpes simplex virus 1 RNA
@ast
ICP27 phosphorylation site mut ...... ind herpes simplex virus 1 RNA
@en
P2093
P2860
P356
P1433
P1476
ICP27 phosphorylation site mut ...... ind herpes simplex virus 1 RNA
@en
P2093
Kara A Corbin-Lickfett
Melanie J Cocco
Santos Rojas
P2860
P304
P356
10.1128/JVI.01388-09
P577
2009-12-16T00:00:00Z