Defective Tibetan PHD2 binding to p23 links high altitude adaption to altered oxygen sensing
about
The role of PHD2 mutations in the pathogenesis of erythrocytosis.Down-Regulation of EPAS1 Transcription and Genetic Adaptation of Tibetans to High-Altitude Hypoxia.Evolutionary history of Tibetans inferred from whole-genome sequencing.Human high-altitude adaptation: forward genetics meets the HIF pathway.2-Oxoglutarate-dependent dioxygenases are sensors of energy metabolism, oxygen availability, and iron homeostasis: potential role in the regulation of aging process.Altitude Adaptation: A Glimpse Through Various Lenses.Genetic selection by high altitude: Beware of experiments at ambient conditionsForkhead Transcription Factor 3a (FOXO3a) Modulates Hypoxia Signaling via Up-regulation of the von Hippel-Lindau Gene (VHL).Beluga whale pVHL enhances HIF-2α activity via inducing HIF-2α proteasomal degradation under hypoxiaEvolution of nonspectral rhodopsin function at high altitudes.The Zinc Finger of Prolyl Hydroxylase Domain Protein 2 Is Essential for Efficient Hydroxylation of Hypoxia-Inducible Factor α.Evolutionary selected Tibetan variants of HIF pathway and risk of lung cancer.Higher androgen bioactivity is associated with excessive erythrocytosis and chronic mountain sickness in Andean Highlanders: a review.Metabolic aspects of high-altitude adaptation in Tibetans.Adaptive genetic changes related to haemoglobin concentration in native high-altitude Tibetans.Measuring high-altitude adaptation.Genetics of human origin and evolution: high-altitude adaptations.Pregnancy at high altitude in the Andes leads to increased total vessel density in healthy newbornsLoss of prolyl hydroxylase domain protein 2 in vascular endothelium increases pericyte coverage and promotes pulmonary arterial remodeling.William Kaelin, Peter Ratcliffe, and Gregg Semenza receive the 2016 Albert Lasker Basic Medical Research Award.Variants of the low oxygen sensors EGLN1 and HIF-1AN associated with acute mountain sickness.Tet1 facilitates hypoxia tolerance by stabilizing the HIF-α proteins independent of its methylcytosine dioxygenase activity.High-altitude adaptation in humans: from genomics to integrative physiology.Human Genetic Adaptation to High Altitudes: Current Status and Future Prospects.Hypoxic lung cancer-secreted exosomal miR-23a increased angiogenesis and vascular permeability by targeting prolyl hydroxylase and tight junction protein ZO-1.Hsp90 Co-chaperone p23 contributes to dopaminergic mitochondrial stress via stabilization of PHD2: Implications for Parkinson's disease.Epigenomics and human adaptation to high altitude
P2860
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P2860
Defective Tibetan PHD2 binding to p23 links high altitude adaption to altered oxygen sensing
description
2014 nî lūn-bûn
@nan
2014 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2014 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2014年の論文
@ja
2014年論文
@yue
2014年論文
@zh-hant
2014年論文
@zh-hk
2014年論文
@zh-mo
2014年論文
@zh-tw
2014年论文
@wuu
name
Defective Tibetan PHD2 binding ...... tion to altered oxygen sensing
@ast
Defective Tibetan PHD2 binding ...... tion to altered oxygen sensing
@en
type
label
Defective Tibetan PHD2 binding ...... tion to altered oxygen sensing
@ast
Defective Tibetan PHD2 binding ...... tion to altered oxygen sensing
@en
prefLabel
Defective Tibetan PHD2 binding ...... tion to altered oxygen sensing
@ast
Defective Tibetan PHD2 binding ...... tion to altered oxygen sensing
@en
P2093
P2860
P356
P1476
Defective Tibetan PHD2 binding ...... tion to altered oxygen sensing
@en
P2093
Abigail W Bigham
Daisheng Song
Katherine J Heaton-Johnson
Lin-sheng Li
Patrick R Arsenault
Qiulin Tan
Stephen R Master
P2860
P304
14656-14665
P356
10.1074/JBC.M113.541227
P407
P50
P577
2014-04-07T00:00:00Z